Navacarzol 5mg Nova Argentia tablets support the treatment of thyroid disorders (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Carbimazole

Ingredient

Composition information	Content
Carbimazole	5mg

Uses

indications

navacarzol drugs are indicated for treatment of some thyroid disorders accompanied by hyperthyroidism.

Pharmacological

carbimazol is an anti -thyroid drug, thioimidazole (imidazol with sulfur). In the body, carbimazol is quickly and completely turned into thiamazol. Therefore, the mechanism of action of carbimazol is also a mechanism of thiamazol. The synthetic inhibitor of thyroid hormone by preventing iodine attaching to the tyrosyl root of thyroglobulin, and also inhibits the combination of two iodotyrosyl roots into iodotyronin.

The non -inhibitor drug of the thyroid hormone has formed in the thyroid gland or in the circulation, does not inhibit the release of thyroid hormones, nor does it affect the effectiveness of the armor hormone from outside. Therefore, carbimazol does not work in poisoning due to overdose of thyroid hormones.

If the thyroid gland has a relatively high IDOD concentration (due to IDOD used before or due to radioactive IDOD for diagnosis), the body will respond slowly to the drug. Carbimazol does not cure the cause of hyperthyroidism and is often not used for prolonged to treat hyperthyroidism. The use of carbimazol is too high and too long time is easy to reduce armor.

The concentration of thyroid hormone decreases, causing the pituitary gland to increase TSH secretion. TSH stimulates the development of the thyroid gland, which can cause goiter. To avoid this phenomenon, when the armor function has returned to normal, must use a moderate low doses, to only inhibit the production of thyroid hormones to a certain extent or combine the use of synthetic thyroid hormones such as levothyroxin so that the pituitary gland does not increase TSH.

Unlike the anti -thyroid drugs of the thyouracil derivative, carbimazol does not inhibit the reduction of thyroxin iodine in the periphery of the citadel of triiodothyronin (the effect of triiodothyronin is much stronger than that of thyroxin). Therefore, in the toxicity of the armor, propylthiouracil is often used more.

Dynamic pharmacology

Carbimazol quickly absorbed through the intestine within 15 - 30 minutes. Methimazol metabolites are detected in the blood.

Sales time varies from 4 to 12 hours depending on each patient.

The distribution volume is about 40 l. The drug is excreted mainly in urine at 70 - 80%.

About 7% of the drug is eliminated in a constant form. Carbimazol can pass the placenta and excrete in milk.

Before taking Navacarzol 5mg Nova Argentia tablets support the treatment of thyroid disorders (5 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

20mg - 60mg Carbimazol per day, divided into 2-3 times a day depending on the level of disorder. The dose is gradually reduced slowly to the smallest dose that can control the disease.

Treatment with high doses in the first 1-2 months under strict control. The dose is reduced by steps until the maintenance dose in the next 3-4 months. The treatment usually lasts for 8 - 12 months.

Dosage and treatment time depend on each different patient, depending on the results of clinical tests and the results of biological tests.

Children

Children 0 - 1 year: 250 µg Carbimazol/kg x 3 times/day.

Children 1 - 4 years old: 2.5 mg of carbimazol x 3 times/day.

Children 5 - 12 years old: 5 mg carbimazol x 3 times/day.

Children 13-18 years old: 10mg Carbimazol x 3 times/day.

Carbimazol is related to bone marrow failure and treatment must be stopped immediately if there is any sign of neutropenia. The child of the child must be required to notify the symptoms and signs of infection, especially sore throat. Counting the white blood cell formula every 3 - 6 months if there are clinical signs of infection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using navacarzol, you may experience unwanted effects (ADR).

The general ratio of unwanted effects is 2 - 14%, weighing less than 1%. The accident occurs depending on the dose, and usually occurs in the first 6-8 weeks.

Common, ADR> 1/100

Skin: allergies, skin rash, itching (2 - 4%).

digestive: nausea, vomiting. Gastrointestinal disorders. Blood: Lose leukocyte usually mild and medium. But about 10% of patients with non -leukemia often decreased to less than 4000/mm3.

Systemic: headache, medium and transient fever.

Few 1/1000

Blood: myeloma, grain leukemia, manifestation of severe fever, chills, sore throat, cough, mouth pain, hoarseness. More often happens if an elderly person or high doses. Reducing blood prothrombin, causing blood anemia.

musculoskeletal: joint pain, arthritis, muscle pain. skin: hair loss, erythema luput syndrome.

dangerous, ADR

liver: jaundice, hepatitis.

kidney: glomerulonephritis. Systemic: headache, mild fever, loss of taste, tinnitus, hearing loss.

Metabolic: high and prolonged doses can cause thyroid reduction, increased goiter volume.

When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Navacarzol drugs contraindicated in the following cases:

Thyroid cancer depends on TSH (thyroid hormones).

There is a history of severe hematological disorders.

liver failure.

Women who are breastfeeding.

Be cautious when using

all patients who use this drug must know that, if any symptoms of fever, sore throat or infection appear, it is necessary to count blood recipe immediately.

Do not use the drug if it is not sure about the level of hyperthyroidism. Check the blood count before starting treatment and each week during the first 6 weeks of treatment (the risk frequency of granulocytosis is 0.7%).

The ability to drive and operate machinery

The drug has almost no effect on the ability to drive and operate machinery.

pregnancy

The fetal thyroid grows very early; However, it was not until the 12th week of pregnancy that started enough iodine. Despite the mild risk of the fetal thyroid function, if necessary, the mother can still maintain the medication.

Treatment should continue with the lowest doses possible so that the mother can maintain the thyroid gland in normal condition, and avoid causing thyroid underlying fetuses due to carbimazol can be absorbed through the placenta.

breastfeeding period

should not be breastfeeding while taking the drug because the drug can go through breast milk.

Drug interaction

with aminophylin, oxtriphylin, theophylin, glycosides cardiac support, beta blockers: When hyperthyroidism, the metabolism of these drugs increases. Use carbimazol if the thyroid gland returns to normal, it is necessary to reduce the dose of these drugs.

With Amiodaron, iodoglycerol, iodine or potassium iodid: drugs with iodine reduces the body's response to carbimazol, so it is necessary to use increased carbimazol doses (amiodaron with 37% iodine).

With anticoagulant drugs Coumarin or indandion: Carbimazol can reduce blood prothrombin, which increases the effects of anticoagulants. Therefore, it is necessary to adjust the anticoagulant dose based on prothrombin.

Radioactive iodine: anti -thyroid drugs can reduce the thyroid gland; Absorption may rise again after a sudden stopping of anti -thyroid drugs for 5 days.

Storage

Store at temperatures below 30 ° C, avoiding light.

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