NECPOD-200 NECLIFE drugs treat infections (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefpodoxime

Ingredient

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Composition information	Content
Cefpodoxime	200mg

Uses

Indications

cefpodoxim is used as oral to treat mild to medium diseases in the lower respiratory tract, including acute pneumonia with the community due to streptococcus pneumoniae or Haemophilus Influenzae sensitive (including the strains of Beta - Lactamase) and the acute bond of the S. Pneumoniae is sensitive and caused by Influenzae or Moraxella (Branhamella, formerly called Neisseria) CatVrhalis, does not produce beta - lactamase.

To treat mild and medium infections in the upper respiratory tract (e.g. sore throat, tonsillitis) due to sensitive streptococcus pyogenes, cefpodoxim is not a priority selected drug, but rather a replacement drug for the main treatment (eg penicilin). Cefpodoxim also plays a role in the treatment of acute otitis media caused by sensitive strains S. Pneumoniae, H.
influenzae (including the strains of Beta - Lactamase) or B. CatVrhalis.

Cefpodoxim is also used to treat mild and medium -sized urinary tract infections, unprovenes (cystitis) due to sensitive strains E. coli, klebsiella pneumoniae, proteus mirabilis, or staphylococcus saprophyticus.

A single dose of 200 mg of Cefpodoxim is used to treat acute gonorrhea, inconstatable, endothelial cervical or anus - rectum of women and gonorrhea in the urethra of women and men, due to the strains with or no penicillinase of Neisseria Gonorrhea.

Cefpodoxim is also used to treat mild infections that have no complications in the skin and skin organizations caused by staphylococcus aureus created or not producing penicilinase and sensitive strains of Streptococcus pyogenes.

Pharmacokology

cefpodoxim is the 3rd generation cephalosporin antibiotic. In principle, Cefpodoxim has a activity for Gram -positive bridge such as pneumococcal (Streptococcus pneumoniae), streptoccus streptoccus (Streptoccus) group A, B, C, G, G -G, G, G -G, G, and with staphylaccaccus aurus, bacteria S. Epidermidis whether or not to produce beta - lactamase. However, the drug has no anti -staphylococcus staphylococcus aureus - penicillin due to replacement of penicillin -mounted protein (the resistance of Methicillin -resistant staphylococcus aureus). Cefpodoxim also works for Gram -negative bacteria, Gram -positive bacilli, and Gram -negative.

The drug has anti -gram -negative bacteria that are important such as Z. Coli, Klebsiella, Proteus Mirabilis and Citrobacter. In contrast to other oral cephalosporins, sustainable cefpodoxim for beta - lactamase due to Hae -Mophilus Influenzae, Moraxella Catatrhalis and Neisseria.

Cefpodoxim has little effect on Proteus vulgaris, Entratia, Serratia Marcesens and Clostridium Perfringens. These bacteria are sometimes completely resistant. Wrapes against methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas spp Cephalosporin.

pharmacokinetics

cefpodoxim Proxetil has little antibacterial effect when not hydrolyzed into cefpodoxim in the body. Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esters, maybe in the intestinal wall, the metabolic of Cefpodoxim metabolites works. Biology of cefpodoxim is 50%. This biological use increases when using Cefpodoxim with food.The half -life of Cefpodoxim's serum is 2.1 - 2.8 hours for patients with normal kidney function.

Half of the serum increases to 3.5 - 9.8 hours in people with kidney disabled. After taking a dose of Cefpodoxim, in healthy adults, there is normal kidney function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/mill, 3.9 micrograms/ml for doses of 100 mg, 200 mg, 400 mg.

about 40% Cefpodoxim binds to plasma proteins. The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking NECPOD-200 NECLIFE drugs treat infections (1 blister x 10 tablets)

How to use

drink at meals.

Dosage

Adults and children over 13 years old: To treat the acute drama of chronic bronchitis or mild acute pneumonia to the community, the usual dose of Cefpodoxim is 200 mg/time, every 12 hours, in 10 or 14 days, respectively.

For pharyngitis and/or mild tonsillitis to medium or mild urinary tract infections or medium complications Cefpodoxim dose is 100 mg every 12 hours, for 5-10 days or 7 days, respectively.

For skin infections and mild and medium -complicated skin organizations, the common dose is 400 mg every 12 hours, for 7-14 days. To treat unprocessed urethral gonorrhea in men, women and gonorrhea - rectal and cervical endometrium in women: take a single dose of 200 mg of cefpodoxim, followed by oral doxycyclin treatment to prevent Chlamydia infection.

Dosage for people with renal failure: It must be reduced depending on the degree of renal failure. For patients with creatinine clearance less than 30ml/ min, and no blood separation, common dose, for each 24 hours apart. The patient is taking blood, taking the dose is usually used 3 times/week.What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

General: headache.

Allergic reaction: rash, urticaria, itching.

Uncommon, 1/1000

Allergic reactions: Reaction such as serum with rash, fever and joint pain and anaphylactic reaction.

Skin: Diverse erythema.

Liver: liver enzyme disorders, hepatitis and temporary jaundice.

Rare, ADR

Blood: Eosin hypernagus, blood disorders.

Kidney: interstitial nephritis is recovered.

Central nerve: Increasing activity, being agitated, difficult to sleep, confusion, increasing tone and dizziness dizziness.

Instructions on how to handle ADR

Cefpodoxim stop treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

must not use cefpodoxim for people who are allergic to cephalosporin and people with porphyrin metabolic disorders.

Be cautious when using

Before starting treatment with cefpodoxim, a thorough investigation of the patient's allergic history with cephalosporin, penicilin or other drugs. Caution should be used for those who are sensitive to penicillin, kidney and pregnant or nursing mothers.

The effect of the drug on the ability to drive and operate machinery

When using Cefpodoxime may experience unwanted effects: headache, increase activity, agitation, difficulty sleep, confuse, increase tone and dizziness dizziness. Therefore, it is necessary to be cautious when driving and operating machinery.

Use drugs for women during pregnancy and lactation

pregnancy

There is no document that mentions the use of Cefpodoxim during pregnancy. However, cephalosporins are often considered safe when used for pregnant women.

Breastfeeding period

cefpodoxim is secreted in breast milk with low concentrations. Despite the low concentration, there are still 3 problems that will occur for breastfed children with cefpodoxim: intestinal micro -disorders, direct effects on the child's body and bacterial culture results will be wrong, if they have to make antibiotics when fever.

Drug interaction

Cefpodoxim absorption is reduced when there is anti -acid, so avoid using cefpodoxim along with anti -acid.

Storage

In a dry place, the temperature does not exceed 30 ° C.

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