Neo-Penotran Mega We Care vaginal vagina treats vaginitis (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Metronidazole, miconazole

Ingredient

Composition information	Content
Metronidazole	500mg
Miconazole	100mg

Uses

indications

Pentronal are indicated in the following cases:

Vaginal candidiasis , bacterial and trichomonas vaginitis, or vaginitis due to coordinated infections. Miconazole nitrate is a broad and effective antifungal drug with pathogenic fungus including Candida albicans. In addition, miconazole nitrate is effective in gram antibacterial (+). Metronidazole is an anti -bacterial and unicellular resistant, effective against vaginal gardnerella and anaerobic bacteria including anaerobic and vaginal trichomonas streptococcus and vaginal trichomonas.

Pharmacokinetics

absorption

The absorption of miconazole nitrate through the vaginal lines is very low (nearly 1.4% of the dose). The bioavailability of Metronidazol through this road is 20% compared to oral.

Distribution

miconidazol nitrate is not found in plasma after using anchor - penotran vaginal. The stable concentration of Metronidazol in plasma reaches 1.6 - 7.2 mg/ml.

Metabolism

metronidazol is metabolized in the liver. This hydroxy metabolite is a substance.

Elimination

Metronidazol's semi -destructive time is 6 - 11 hours. Nearly 20% of the drug is secreted in a constant form.

Before taking Neo-Penotran Mega We Care vaginal vagina treats vaginitis (2 blisters x 7 tablets)

How to use

use vaginal lines.

Dosage

must not be used without consulting your doctor.

Put deep into the vagina in the evening in 14 days or put 1 tablet in the evening and 1 tablet in the morning in 7 days.

Cases of recurrence, or vaginitis resistance to other treatments, should be placed deep inside the vagina 1 tablet in the evening and 1 tablet in the morning within 14 days.

should put the pills deep into the vagina while in a lying position.

Elderly (over 65 years old): used as young people.

Children: Do not use for children.

Not used for virgin women.

Do not swallow or use by another path.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms due to the overdose of Metronidazol are nausea, vomiting, abdominal pain, diarrhea, itching, metal flavor in the mouth, loss of movement, abnormal, convulsions, leukopenia, dark urine.

Symptoms due to overdose of miconazole nitrate are nausea, vomiting, sore throat and mouth, headache, diarrhea.

How to handle

If you accidentally take this large amount of medicine, you can use the appropriate measure of gastric lavage if necessary. The treatment is for those who drink at a dose of 12 g of metronidazol.

No specific antidote, symptomatic treatment is applied.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using pills - Penotran , you may experience unwanted effects (ADR).

Hypersensitivity reactions such as skin rash and other side effects such as abdominal pain, headache, itching, vaginal burning and stimulating sensation may occur but rare. The frequency of the body side effects is very low because the absorption of metronidazol through the vaginal tract makes the drug concentration in plasma very low (2 - 12% compared to the concentration of drugs achieved in plasma due to oral use).

miconazole nitrate can cause vaginal irritation (itching, burning) like when using other imidazol derivatives (2 - 6%). Due to the vaginal mucosal inflammation in vaginitis, vaginal stimulation signs (vaginal burns, vaginal itching) can be seen in the first time using this drug or around the 3rd day of the treatment. When continued treatment, these troubles will disappear very quickly.

If serious stimulating signs appear, it is advisable to stop treatment. Side effects due to the use of Metronidazol system (for example oral) including sensitive (rare) hypersensitivity reactions, leukopenia, loss of movement air conditioning, mental changes, peripheral neuropathy when using overdose or prolonged use, convulsions, rare diarrhea, constipation, dizziness, headache, loss of appetite, vomiting, abdominal pain, rare and mental abdominal vomit mouth, fatigue. The side effects are very rare, because the concentration of Metronidazole in the blood is low after using sugar in the vagina.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Penotran contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

in the first 3 months of pregnancy.

Cases of porphyrin metabolism disorders.

epilepsy and severe liver dysfunction.

Be cautious when using

After the first three months of pregnancy, the Neo -Penotran vaginal bullet may be used in cases where the physician is necessary, but should be used with control. Do not continue breastfeeding during anchor - penotran, as metronidazol will appear in breast milk. At the end of treatment, you can start breastfeeding again 24 - 48 hours later.

During the treatment process and at least 24 - 48 hours after the end of the treatment, the patient should be noted as not to drink alcohol, because there is the ability to cause the same reaction as when taking Disulfiram. The substrate in the formula of the vaginal bullet can interact with rubber or plastic products that are substances used in the vaginal diaphragm to avoid pregnancy. It is recommended to treat people at the same time having sex with vaginal trichomonas. If you need more information, please consult your doctor.

The ability to drive and operate machinery

Neo -Penotran vaginal bullets do not affect the ability to drive and operate machinery.

During pregnancy

After the first 3 months of pregnancy, the Neo -Penotran vaginal bullet may be used in cases where the physician is necessary, but should be used with control.

The period of breastfeeding

should not continue breastfeeding while treating an Neo - penotran, because Metronidazol will appear in breast milk. At the end of treatment, you can start breastfeeding again 24 - 48 hours later.

Model interactive

alcohol: alcohol intolerance (reaction is like using disulfiram).

Oral anticoagulant: Increases anticoagulant effect.

Phenytoin: The blood level of blood in the blood may increase, metronidazol levels may be reduced.

Phenobarbital: Reducing the concentration of metronidazol in the blood.

disulfiram: Some effects (mental reactions) on the central nervous system may occur.

cimetidine : Metronidazole concentration in the blood and the risk of neurological side effects may increase.

Lithium: It can be seen increasing the toxicity of lithium.

Astemizol and Terfenadin: Metronidazol and Miconazole inhibit the metabolism of these two drugs that increase the concentration of drugs in plasma. The effect of drugs on blood levels of liver enzymes, glucose (Hexokinase method), Theophyllin and Procainamid may be encountered.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

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