Neo-Tyrynan Bouchara vaginal vagina treatment for vaginitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazole, neomycin sulfate, nystatin

Ingredient

Composition information	Content
Metronidazole	500mg
Neomycin sulfate	65000iu
Nystatin	100000iu

Uses

indications

NEO - TERGYNAN is indicated in the following cases:

Treatment of vaginitis caused by sensitive pathogens and nonspecific vaginitis.

Neomycin is an antibacterial antibiotic of Aminoglycosides.

Nystatin is an active polyphic antifungal agent against Candida species.

antibacterial spectrum

metronidazol

Critical concentration of sensitivity to intermediate sensitive strains and intermediate sensitive strains with resistance is:

Sensitive ≤ 4 mg/l and resistance> 4 mg/l.

The change in the resistance of some bacteria for Metronidazol in France is as follows:

Sensitive: Helicobacter Pylori (30%), Bacteroides Fragilis, Bifidobacterium (60 - 70%), Bilophila, Clostridium, Clostridium difficile, Clostridium perfringens, eubacterium (20 - 30%), Fusobacterium, peptostreptoccus, Prevotella, Porphyromonas, Veillonella. vaginalis.

Neomycin

The change in the resistance of some bacteria for Neomycin in France is as follows:

Sensitive: Corynebacterium, Listeria monocytogenes, Staphylococcus Meti -S, Acinetobacter (mainly Acinetobacter baumiii) (50 - 70%), Branhamella Catatrhalis, Campylobacter, Citrobacter Freundii (20 - 25%), Citrobacter Kooseri, EntobioBacterii Aerogenes, Entrobacter Clacae (10 - 20%), Proteus Mirabilis (20 - 50%), Proteus Vulgaris, Providencia Rellgeri, Salmonella, Serratia, Shigella, Yersinia, Pasteurella.

Resistance: Enterococci, Nocardia Asteroides, Staphylococcus meti –r*, streptococcus, Alcaligenes Denitroficans, Burkholderia, Flavobacterium sp., Providencia Stuartii, Pseudomonas Aeruginosa, Stenotrophomonas, Stric Aerobia, Stric Aerobia Bacteria, Chlamydia, Mycoplasma, Rickettsia.

The rate of resistance for methicillin is about 30-50% for staphylococcus a staphylococcus group and more common in the hospital.

pharmacokinetics

for Metronidazol

absorption, distribution

pass through the whole body completely after using vaginal lines. Selling time in plasma from 8 to 10 hours. Integrated with low plasma proteins, less than 20%. Quickly diffuse into the lungs, kidneys, liver, bile, cerebrospinal fluid, skin, saliva and vaginal discharge. This substance can pass the placenta and into breast milk.

Metabolism

Mainly in the liver, forming two non -combined oxidation substances (5 - 30% active).

Elimination

Excretion mainly in the urine. About 35 - 65% of the absorbed dose is excreted in the urine in the form of metronidazol or in the form of oxidant metabolites.

Before taking Neo-Tyrynan Bouchara vaginal vagina treatment for vaginitis (1 blister x 10 tablets)

How to use

After washing your hands thoroughly, moisturizing the pill by dipping in water for 20-30 seconds before placing it. In order for the drug to dissolve well in the vagina, the pill needs to be at least moisture in the vagina. In the case of vaginal dryness, the drug may not disintegrate completely.

After moisturizing, the tablet should be placed deep into the vagina, the best in the expansion position.

The simplest way is to lie on your back with your knees folded and expanded. Then stay within 15 minutes after placing.

Dosage

Adults

Vaginal line.

1 vaginal tablet once or 2 times/day for 10 consecutive days, combined with oral treatment if necessary.

No treatment with metronidazol for more than 10 days and no repetition of treatment for more than 2-3 times/year.

Children

Not for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, with other metronidazol containing substances, overdose has been reported in some cases using single -dose metronidazol to 12 g (oral). Symptoms include vomiting, loss of mild disorientation.

In addition, in case of high doses and/or long -lasting time: medium leukopenia and peripheral sensory neuropathy have been reported to be reduced when stopping treatment.

Handling

In case of overdose, symptomatic treatment is needed because there is no specific antidote for Metronidazol.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using NEO - Tergynan , you may experience unwanted effects (ADR).

rarely

Gastrointestinal disorders benign: Nausea, mouth with metal taste, anorexia, epigastric shrinkage, vomiting, diarrhea.

Symptoms and mucous membranes: allergies (urticaria, itching), hot overflow, flap inflammation with a feeling of dry mouth. Peripheral sense: usually recovered from treatment.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

NEO - TERGYNAN Contraindicated in the following cases:

This drug is not used in cases of hypersensitivity to one of the ingredients of the drug.

Be cautious when using

involving Metronidazol: Check the number of leukocytes of all kinds in patients with a history of hematological disorders or patients with high dose treatment and/or in a long time.

Metronidazole can cause treponema immobility and lead to false positive results in Nelson tests.

Related to Neomycin: Limit the treatment time to reduce the risk of selection of resistance or superinfection with these bacteria.

The ability to drive and operate machinery

Must pay attention because this drug can cause dizziness.

Pregnancy

because it contains neomycin, an aminoglycoside antibiotic that can be toxic to the ears and can cause systemic effects, should not use this medication during pregnancy. The period of breastfeeding

There is no data on the drug through breast milk, avoiding the use of this drug in case of breastfeeding.

Drug interaction

Not used in combination with

Sperm killers: Any local vaginal treatment will be inactivated in place contraception on the spot with disinfectants.

Alcohol (drinks or excipients in pharmaceuticals): Due to the same effect as alcoholic syndrome (hot, blushing, vomiting, fast heartbeat). Advise patients to use alcoholic drinks or pharmaceuticals. It should be noted that the completely elimination of the drug is based on the sale time of the drug before use or alcoholic pharmaceuticals.

disulfiram: When used in combination with Disulfiram, it can cause a delusion or confusion, recovery when stopping using the drug.

Busulfan: When combined with high -dose Busulfan, Metronidazol can double the concentration of Busulfan.

Needing on the kidneys while combined with enzyme anti -seizure drugs: reduces the plasma metronidazol levels due to liver metabolism by enzyme induction.

Clinical monitoring and adjustable dose of metronidazol during treatment with induction drugs and after stopping the drug.

Lithium: causing hyperlemia blood lithium can reach toxic threshold, with signs of lithium overdose. Need to closely monitor blood lithium and adjust the lithium dose.

rifampicin : Causes a reduction in plasma metronidazole due to liver metabolism with rifampicin. Clinical monitoring and can adjust the metronidazole dose during and after stopping rifampicin.

Warfarin: Increases the effects of oral anticoagulant drugs and the risk of bleeding caused by the loss of these drugs in the liver.

It should be noted when combined with 5 - fluorouracil: increasing toxicity 5 - FU due to reducing the clearance of this drug.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.