Neocilor Incepta Siro Treatment of allergic rhinitis, urticaria (50ml)

Dosage form Bottle x 50ml
Specifications Desloratadine

Ingredient

Thành phần cho 5ml

Composition information	Content
Desloratadine	2.5mg

Uses

Indications

Neocilor Syrup drugs are prescribed in the following cases:

Seasonal allergic rhinitis

Neocilor Syrup is indicated to reduce symptoms related to the nose or not related to the nose of allergic rhinitis.

Annual rhinitis all year round

Neocilor Syrup is indicated to mitigate the symptoms related to the nose or not related to the nose of allergic rhinitis all year round.

Spontaneous chronic urticaria

Neocilor Syrup is designated to reduce itchy symptoms, reduce the number of skin rashes

Pharmacokological

Desloratadin is a 3 -round antihistamine that has a long -lasting effect with selective histamine resistance on H1 receptor. The data on receptors shall show that at a concentration of 2 - 3mg/ml (7nanomol), the desloratadin shows typical interactions with H1 receptors in humans. Desloratadin inhibits the release of histamine from moisturizing in vitro testing. Desloratidine has a long -lasting effect and does not cause drowsiness because it is not easy to pass through the bloody barrier.

pharmacokinetic

absorption

Desloratadin is well absorbed with the highest concentration achieved after 3 hours. The area under the curve (AUC) is 56.9ng. Annaments/ml and the peak concentration in the average plasma in a stable state is about 4ng/ml. The bioavailability of desloratadin is proportional to the dose ranges from 5mg to 20mg.

Metabolism

Desloratadin is metabolized mostly into the main metabolites are 3 - hydroxydesloratadin, then participate in glucorin:

reaction.

Distribution

Desloratadin and 3 - Hydroxydesloratadin, respectively, are associated with plasma proteins 82 - 87% and 85 - 89%.

Elimination

The average disposal time of desloratadin is 27 hours. The accumulation after 14 days of use is suitable for the sale time and frequency of use.

Special subjects

Patients with renal failure: In patients with mild to moderate renal failure, average cmax concentration and AUC value increase to about 1.2 and 1.9, compared to normal people. In patients with severe renal impairment or those who depend on the hemolysis, CMAX and the AUC value increase to approximately 1.7 and 2.5 times respectively. Desloratadine and 3 - hydroxydesloratadin are less except for blood decomposition. Dosage should be adjusted for patients with renal failure.

Hepatic failure: Patients with liver failure, not to mention the severity of severity, AUC increased by approximately 2.4 times compared to normal people. The oral clearance can be measured in patients with mild, medium, and severe liver failure, 37%, 36% and 28% compared to normal people. It also records an average increase in the sale time in patients with liver failure. The dose should be adjusted for patients with liver failure.

Before taking Neocilor Incepta Siro Treatment of allergic rhinitis, urticaria (50ml)

How to use

Take oral use.

Used during or after meals.

Dosage

Children from 6 months - 11 months: 1mg Desloratadin/2ml/1 day.

Children from 12 months - 5 years old: 1.25mg Desloratadin/2.5ml (teaspoon)/1 day.

Children from 6 years old - 11 years old: 2.5mg Desloratadin/5ml (2 teaspoons)/1 day.

Adults and children aged 12 years and older: 5mg Desloratadin/10ml (4 teaspoons)/1 day.

Patients with renal failure or liver failure: In patients with renal impairment or hepatic insufficiency on the beginning of the recommended use of 5mg/10ml (4 teaspoons)/Daily way based on pharmacokinetics parameters.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Can treat symptoms and support treatment. Based on multi -dose clinical trials, using a number of desloratadine up to 45mg (9 times the treatment dose), no clinical consequences are recorded. Desloratadin is not eliminated deducted from hemolysis, it is unknown whether the drug is eliminated deducted when the abdominal canopy.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Neocilor Syrup, you may experience unwanted effects (ADR).

generally desloratadin is well tolerated. The common side effects are recorded during the Desloratadin treatment period: fatigue, headache, dry mouth.

Other rare reactions: dizziness, drowsiness, insomnia, fast pulse, chest drums, abdominal pain, nausea, vomiting, indigestion, diarrhea, increased liver enzymes, increased bilirubin, hepatitis, muscle pain, hypersensitivity reactions (anaphylaxis, angioemia, difficulty, itching, red rash and urticaria).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Neocilor Syrup drugs are contraindicated in the following cases:

Desloratadin is contraindicated in hypersensitivity patients or has a special reaction to desloratadin, with loratadin or any excipients of the drug.

Precautions when using

The efficiency and safety of Neocilor Syrup in children under 6 months of age has not been established. In case of severe renal failure, desloratadine may be used cautiously. Patients with Galactose -intolered genetic problems, patients with lactase enamel or glucose absorption - Galactose should not be used by this drug.

The ability to drive and operate machinery

In clinical research on driving ability, no bad cases occur in patients using desloratadin. However, patients need to be notified of rare symptoms such as drowsiness, which can affect the ability to drive machinery.

Pregnancy

There is no adequate and well -controlled research when using desloratadin in pregnant women. Desloratadin should not be used in pregnancy unless the benefits are expected for the mother to outperform the risks that may occur for the fetus.

Breastfeeding period

Desloratadin may be through breast milk, so it is necessary to decide whether to stop the medicine during breastfeeding or not, should be noted about the importance of the mother.

Drug interactions

There is no clinical interaction recorded in trials related to drug interactions between desloratadin when used with erythromycin or ketoconazole. In pharmacological - clinical trials, sharing desloratadin with alcohol shows that the drug does not enhance the inhibition effect of alcohol on the nervous system.

Storage

Store drugs in dry, cool. The temperature does not exceed 30 ° C. Avoid light.

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