Neupencap medicine 300mg Danapha treat pain due to peripheral neuritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	300mg

Uses

indications

Neupencap drug indicated in the following cases:

Support treatment in local epilepsy in adults and children over 3 years old. On experimental animals, the drug has anti -stretching effects after electric shock and also inhibits convulsions caused by pentylenetetrazol. The effect in the above experiment is similar to Valproic acid but unlike Phenytoin and carbamazepin. The chemical structure of Gabapentin is similar to the neurotransmitter inhibitor of GABA, but Gabapentin does not directly affect GABA receptors, does not change the structure, release, transformation and recovery of GABA.

Dynamic pharmacokinetics

Cailbapentin absorbed through the gastrointestinal tract through saturation mechanism (when the dose increases, bioavailability decreases). The drug reaches the peak concentration in plasma after 2 hours and reaches a stable concentration after 1 -2 days. The effective serum concentration of the drug has not been determined. In some studies, the number of convulsions only decreased in people with gabapentin serum levels per mg/liter (11.7 micromol/liter). Gabapentin plasma concentration says they are within 2 mg/liter to 20 mg/liter.

Birth is about 60% when used at a dose of 1.8 g/24 hours and does not correspond to the dose, even when the dose increases over 1.8 g/24 hours, bioavailability decreases (bioavailability about 35% when used at a dose of 4.8 g/24 hours). Food less affecting the speed and level of absorption.

In elderly patients and patients with impaired renal function, plasma gabapentin clearance is reduced. Gabapentin can be eliminated from plasma by hemolysis, so the dose adjustments for these patients are needed.

Rabapentin Phan Bo is throughout the body, entering breast milk, linking with very low plasma proteins (

Gabapentin is almost no metabolic in the body and excreted mainly through the kidneys in a constant form. Half of Gabapentin about 5 hours to 7 hours in people with normal kidney function.

Before taking Neupencap medicine 300mg Danapha treat pain due to peripheral neuritis (3 blisters x 10 tablets)

How to use

Gabapentin oral oral oral tablets, at the time of oral or non -snack.

Dosage

anti -epileptic

Adults and children over 12 years old

The first day: Take the dose of 300 mg x 1 time. Maximum not exceeding 2400 mg/day.

Children 6 - 12 years old

First day: Take the dose of 10 mg/kg/day, divide 3 times.

Monday: Take the dose of 20 mg/kg/day, divide 3 times.

Tuesday: Dosage 25 - 35 mg/kg/day, divided 3 times.

Maintenance dose is 900 mg/day for children weighing 26 - 36 kg and 1200 mg/day for children weighing 37 - 50 kg, dividing or drinking 3 times a day.

Children 3 - 6 years old: pain dose 10 - 15 mg/kg/day, divided 3 times; Increase the dose in 3 days to reach 25 - 30 mg/kg/day, divide orally 3 times a day.

There is no evaluation of the use of gabapentin for children under 12 years old with renal function.

Treatment of pain due to peripheral neuritis

Adults: Take no more than 1800 mg/day, divided 3 times. Or use as follows:

First day: Take a dose of 300 mg. Date.

Elderly: The dose may be low due to poor kidney function.

Dosage adjustment in patients with renal failure

Creatinine clearance from 50 - 79 ml/minute: dose from 600 - 1800 mg/day, divided into 3 times.

Creatinine clearance from 30 - 49 ml/min: Self -dose 300 - 900 mg/day, divided into 3 times.

Creatinine clearance from 15 - 29 ml/minute: The dose from 300 mg is divided into 3 times to take Japanese to 600 mg divided 3 times daily.

Creatinine clearance

For patients who are having never used gabapentin: the starting dose is from 300 - 400 mg and then reduces to 200 - 300 mg after every 4 hours of dialysis. For days without hemolysis, do not use gabapentin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Most cases of overdose recover after using supportive treatment. There may be drugs from the body by hemolysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Gabapentin is usually well tolerated. Side effects are usually light or medium and tend to gradually decrease as the mind continues. The most common side effect is for the nerves and is often the cause of stopping the drug.

Common, ADR> 1/100

Neurological: Mobility loss of coordination, eyeball, fatigue, dizziness, edema, sleepiness, memory loss. Children from 3 to 12 years old: encountering neurological problems such as anxiety, changing each behavior (harassing, feeling refreshing or depression, too excited, anti -opposition attitude ...)

digestive: indigestion, dry mouth, constipation, abdominal pain, diarrhea skin.

Blood: leukopenia

Neurological: Memory loss, loss of language, depression, irritability or mental change, temperament, mild paralysis, decrease or loss of sensory, headache. to.

Rare, ADR

Neurology: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise function, mental disorders. Eye.

Instructions on how to handle ADR

Unwanted effects are usually mild or medium and tend to gradually decrease within 2 weeks of continuing treatment.

Mobilization is often related to the dose. If the dose is reduced without support, it is necessary to stop the drug. If there is a suspected Stevens Johnson syndrome, the drug must be stopped.

Do not stop the drug suddenly VL may increase the frequency of seizures. Before stopping the drug or switching to other anti -epileptic drugs, it is necessary to reduce the dose slowly within at least 7 days.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Neupencap drug contraindicated in the following cases:

Hypersensitivity to Gabapentin or any ingredients of the drug.

Be cautious when using

Use cautiously for people with a history of mental disorders, impaired kidney function and hemolysis, car operators or machinery.

The drug can cause false positive when testing proteinuria.

The effect of the drug on the ability to drive and operate machinery

should not use the drug for people who are driving and operating machinery.

Use drugs for women during pregnancy and lactation

only use drugs for pregnant women when they are really necessary and consider higher benefits than the risk for the fetus. Gabapentin into breast milk. The effect of the drug on infants is unknown, so only gabapentin for women who are breastfeeding when they are really necessary and consider higher benefits than risks than risks.

Drug interaction

When used simultaneously, gabapentin does not change the pharmacokinetics of commonly used anti -epileptic drugs such as carbamazepin, phenytoin, valproic acid, phenobarbital, diazepam.

Anti -acid drugs reduce the bioavailability of gabapentin by about 20% due to the impact on the absorption of the drug. Gabapentin must be used after at least 2 hours of antacids.

Morphin can reduce gabapentin clearance, so for patients who use these two drugs at the same time, they need to be monitored with excessive central nervous inhibition signs, so the dose should be reduced when using these two drugs simultaneously.

cimetidine may reduce the clearance of gabapentin in the kidneys, but this interaction is not clinically significant.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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