Neuronstad 300mg Stella medicine supports local epilepsy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	300mg

Uses

indications

Neuronstad drug indicated in the following cases:

Support treatment in local epilepsy.

ATC code: N03AX12.

Gabapentin is an anti -epileptic drug, the mechanism is not clear. On test animals, the drug has anti -stretching effects after electric shock and also inhibits seizures caused by pentylenetetrazol. The chemical structure of Gabapentin is similar to neurotransmitter inhibitors, gamma-aminobutyric acid (GABA), but Gabapentin does not directly affect GABA receptors, does not change the structure, release, metabolism and restoration of GABA.

pharmacokinetics

gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when the dose increases, bioavailability decreases). The drug reaches the peak concentration in plasma after drinking 2 hours and reaches a stable concentration after 1-2 days. The effective serum concentration of the drug has not been determined. However, in a study, the number of convulsions only decreased in people with gabapentin serum levels per mg/liter (11.7 micromol/liter). Gabapentin plasma concentration is generally within 2 mg/liter to 20 mg/liter.

Biochemistry is about 60% when used in a dose of 1.8 g/24 hours and does not correspond to the dose, and when the dose increases over 1.8 g/24 hours, bioavailability decreases (bioavailability about 35% when used at a dose of 4.8 g/24 hours). Foods less affect the speed and level of absorption. In elderly patients and patients with impaired renal function, plasma gabapentin clearance is reduced. Gabapentin can be eliminated from plasma by hemolysis, so the dose adjustments for these patients are needed.

gabapentin is distributed throughout the body, into breast milk, linked to very low plasma proteins (

Gabapentin is almost no metabolic in the body and excreted mainly through the kidneys in a constant form. Gabapentin waste sale time is about 5 to 7 hours in people with normal kidney function.

Before taking Neuronstad 300mg Stella medicine supports local epilepsy (10 blisters x 10 tablets)

How to use

Neuronstad oral oral medication, the time to take the drug does not depend on the meal. Neuronstad is used as a secondary drug to coordinate with other anti -epileptic drugs. Single use may not work.

Dosage

anti -epileptic

Adults and children over 12 years:

The first day: 300 mg x 1 time.

Monday: 300 mg/time x 2 times. Maximum not exceeding 2400 mg/day. Should divide the total daily dose for each drug and the medication distance should not exceed 12 hours. When using high doses can be divided 4 times/day.

For patients with impaired kidney function and hemolysis must reduce the dose; The appropriate dose needs to be adjusted according to creatinine clearance, recommended as follows:

Creatinine clearance (ml/minute) Dosage The time

15 - 29 300 mg/day, divided 3 times The loading dose is 300 - 400 mg for the first person to use gabapentin, then 200 - 300 mg after every 4 hours of hemolysis.

Children from 6 to 12 years old, weighing from 30 - 36 kg:

First day: 300 mg x 1 time/day.

Monday: 300 mg x 1 time/day. Add daily, extending the added time (up to weekly) more appropriate.

There is no evaluation of the use of gabapentin for children under 12 years old with renal function.

Treatment of pain caused by peripheral nerves, shingles after shingles

Adults: Take no more than 1800 mg/day, divided 3 times. Or use as follows:

The first day: 300 mg.

Monday: 300 mg/time, 2 times a day.

Elderly: Need to adjust the dose due to reduced kidney function.

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Most cases of overdose recover after using supportive treatment. There may be drugs from the body by hemolysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Gabapentin tolerates well. Side effects are usually mild or medium and tend to gradually decrease when continued treatment. The most common side effects for nerves and are often the cause of stopping.

Common (1/100 ≤ ADR

Neurological: Mobility loss of coordination, vibration of the eyeball, fatigue, dizziness, edema, drowsiness, memory loss. flow. Virus.

Neurological: Memory loss, loss of language, depression, irritability, temperament or mental change, mild paralysis, reduction or loss of sensory, headache. to.

Rare (1/10,000 ≤ ADR Neurological: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise, mental disorders. Eye: itchy eyes, watery eyes, retinopathy, iritis When using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Neuronstad drugs contraindicated in the following cases:

Hypersensitivity to Gabapentin or any ingredients of the drug.

Be cautious when using

Use cautiously for people with a history of mental disorders, impaired kidney function and hemolysis, car operators or machinery.

The drug can cause false positive when testing proteinuria in patients using gabapentin.

Unwanted effects are usually mild or medium and tend to gradually decrease within 2 weeks of continuing treatment.

Mobilization of loss of coordination is related to the dose. If the dose is reduced without helping, it is necessary to stop the drug.

If there is a suspected Stevens-Johnson syndrome, the drug must be stopped.

Do not stop the drug suddenly because it can increase the frequency of seizures. Before stopping the drug or switching to other anti -epileptic drugs, it is necessary to reduce the dose slowly within 7 days.

The effect of the drug on driving and operating machinery

gabapentin may have a slight or medium impact on the ability to drive and operate machinery. Gabapentin acts on the central nervous system and can cause drowsiness, dizziness or other similar symptoms. Even when the above effects are only mild and medium, it can be potential danger in driving patients or operating machinery. This is especially true at the beginning of treatment and after increasing the dose.

Use drugs for women during pregnancy and lactation

Pregnant women

gabapentin causes teratogenicity on rodents. There is no adequate and controlled research on pregnant women. However, only medication for pregnant women when really necessary and have a higher consideration of benefits than the risk for the fetus.

breastfeeding women

When taken orally, gabapentin gets breast milk. The effect of the drug on infants is still unknown, so only gabapentin for breastfeeding women is really necessary and has carefully considered the benefits higher than the risk risk.

Drug interaction

When used simultaneously, Gabapentin does not change the pharmacokinetics of other anti -epileptic drugs such as carbamazepin, phenytoin, valproic acid, phenobarbital, diazepam. Gabapentin's antacids reduces the bioavailability of about 20% due to the absorption of drugs. Gabapentin must be used after at least 2 hours of antacids.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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