Neuronstad hard capsules 300mg Stella treat local epilepsy, neuritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition informationContent
Gabapentin300mg

Uses

indications

Neuronstad is indicated in the following cases:

  • support for local epilepsy.
  • Treatment of inflammation of peripheral nerves, shingles after shingles. On test animals, the drug has anti -stretching effects after electric shock and also inhibits convulsions caused by pentylenetetrazol.

    The chemical structure of Gabapentin is similar to neurotransmitter inhibitors, Gama-Aminobutyric Acid (GABA), but Gabapentin does not directly affect GABA receptors, does not change the structure, release, metabolism and recovery of GABA.

    pharmacokinetics

    absorption:

  • Gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when the dose increases, bioavailability decreases). The drug reaches the peak concentration in plasma after taking 2 hours and reaches a stable concentration after 1–2 days.
  • The effective serum level of the drug has not been determined. Born is about 60% when using a dose of 1.8 g/24 hours and does not correspond to the dose, when the dose increases over 1.8 g/24 hours, bioavailability decreases (bioavailability about 35% when used at a dose of 4.8 g/24 hours).

    gabapentin is distributed throughout the body, into breast milk, linked to very low plasma proteins (

    Metabolism:

    gabapentin is almost no metabolism in the body.

    Era:

    Mainly eliminated drugs through the kidneys in the form of constant. Gabapentin waste time is about 5–7 hours in people with normal kidney function. In elderly patients and patients with impaired renal function, plasma gabapentin clearance is reduced. Gabapentin can be removed from plasma by hemolysis, so the dose adjustments for these patients are needed.

    • Before taking Neuronstad hard capsules 300mg Stella treat local epilepsy, neuritis (3 blisters x 10 tablets)

    How to use

    oral medication. The time to take the drug does not depend on the meal. Neuronstad is used as a secondary drug to coordinate with other anti -epileptic drugs. Use monomers may not be effective.

    Dosage

    Anti -epilepsy:

    Adults and children> 12 years old:

  • First day: 300 mg x 1 time.
  • Monday: 300 mg/time x 2 times.
  • Tuesday: 300 mg/time x 3 times.
  • After that, the dose may increase every step of 300 mg/day, based on the patient's response and tolerance until effective treatment is reached, usually 900–1800 mg/day, divided 3 times, maximum no more than 2400 mg/day. Should divide the total daily dose for each drug and the medication distance should not exceed 12 hours. When using high doses can be divided 4 times/day.
  • For patients with impaired renal function and hemolysis must reduce the dose, the appropriate dose should be adjusted according to the creatinine clearance, which is recommended as follows:

    • Creatinine clearance (ml/minute)

    Dosage

    50–70

    600–1200 mg/day, divided 3 times.

    30–49

    300–600 mg/day, divided 3 times.

    15–29

    300 mg/day, divided 3 times.

    300 mg once a day, divided 3 times.

    200–300 mg (*)

    Children 6–12 years old, weighing 30–36 kg:

  • First day: 300 mg x 1 time/day.
  • Monday: 300 mg x 1 time/day.
  • Tuesday: 300 mg x 1 time/day.

    • Normal dose: 300 mg/time x 3 times/day.

  • Maintenance dose: 300 mg/time x 3 times/day.

    • Some children do not tolerate the daily increase, prolonging the increase in time (up to weeks) may be more appropriate.

    There is no evaluation of the use of gabapentin for children under 12 years old with renal function.

    Treatment of pain caused by inflammation of peripheral nerves, after shingles:

    Adults: Take no more than 1800 mg/day, divided 3 times. Or use as follows:

  • First day: 300 mg.
  • Monday: 300 mg/time x 2 times/day.
  • Tuesday: 300 mg/time x 3 times/day.

    • After that, the dose may increase by 300 mg/day, based on the response and tolerance of the patient, until the maximum dose is 1800 mg/day, the total dose/day is divided, drink 3 times.

    Elderly people: Need to adjust the dose due to reduced kidney function.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There may be drugs from the body by hemolysis.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using neuronstad, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Neurological: Mobility lost coordination, vibration of eyeball, fatigue, dizziness, edema, drowsiness, memory loss.
  • Children 3–12 years old: encounter neurological problems such as anxiety, change of behavior (fussing, refreshing or depression, too excited, anti -opposition attitude ...).
    • digestive: indigestion, dry mouth, constipation, abdominal pain, diarrhea. Cardiovascular: Foreign eagle. Respiratory: rhinitis, sore throat, cough, pneumonia.
  • Eyes: see one two, reduce vision.
    • muscle - Muscle: muscle pain, joint pain.
  • Skin: rash, skin rash.
    • blood: leukopenia.

    Other: impotence, virus infection.

    Uncommon, 1/1000

  • Neurological: Memory loss, loss of language, depression, irritability, mental or temperament change, mild paralysis, decrease or loss of sex, headache.
    • digestive: digestive disorders, bleeding, stomatitis, loss or taste disorders. Cardiovascular: Hypotension, angina, peripheral disorders, suspense.

    Other: weight gain, enlarged liver.

    Rare, 1/10000

  • Neurological: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise function, mental disorders.
    • Digestive: Stomach ulcer, colitis, colitis, rectal inflammation. Respiratory: cough, hoarseness, respiratory mucosa, lung ventilation, pulmonary edema. eyes: itchy eyes, watery eyes, retinopathy, iritis.
  • Muscle muscle: cartilage, osteoporosis, back pain.
    • blood: leukopenia (usually asymptomatic), prolonged bleeding time. fever or cold.
  • Stevens - Johnson syndrome.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated:

    Neuronstad drugs contraindicated in the following cases:

  • Hypersensitivity to Gabapentin or any ingredients of the drug.

    • Be cautious when using

    Use cautiously for people with a history of mental disorders, impaired kidney function and hemolysis, car operators or machinery.

    The drug can cause false positive when testing proteinuria in patients using gabapentin.

    Unwanted effects are usually mild or medium and tend to gradually decrease within 2 weeks of continuing treatment.

    Mobilization of loss of coordination is related to the dose. If the dose is reduced without helping, it is necessary to stop the drug.

    If suspected to have Stevens - Johnson syndrome, the drug must be stopped.

    Do not stop the drug suddenly because it can increase the frequency of seizures. Before stopping the drug or switching to other anti -epileptic drugs, it is necessary to reduce the dose slowly within 7 days.

    The ability to drive and operate machinery

    gabapentin may have a slight or medium impact on the ability to drive and operate machinery. Gabapentin acts on the central nervous system and can cause drowsiness, dizziness or other similar symptoms.

    When these effects are only mild and medium, it can also be potential danger in patients driving or operating machinery. This is especially true at the beginning of treatment and after increasing the dose.

    Pregnancy

    gabapentin causes teratogen on rodents. There is no adequate and controlled research on pregnant women. However, only medication for pregnant women when they really need and consider higher benefits than the risk for the fetus.

    breastfeeding period

    When orally, gabapentin gets breast milk. The effect of the drug on infants is still unknown, so only gabapentin in breastfeeding women is really necessary and has carefully considered the benefits higher than the risk risk.

    Drug interaction

    When used simultaneously, Gabapentin does not change the pharmacokinetics of other anti -epileptic drugs such as carbamazepine, phenytoin, valproic acid, phenobarbital, diazepam.

    Anti -acid drugs reduce the bioavailability of gabapentin by about 20% due to the impact on the absorption of the drug. Gabapentin must be used after at least 2 hours of antacids.

    Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

    Storage

    Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

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