Neustam hard capsules 400mg pymepharco treat muscle vibration, anemia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Piracetam

Ingredient

Composition information	Content
Piracetam	400mg

Uses

Indications

Neustam is a product of Pymepharco containing active ingredient Piracetam used in case of muscle vibration originating from the cerebral cortex, anemia, intellectual decline in the elderly, dizziness.

Pharmacology

piracetam (derivative of gamma aminobutyric acid, GABA), is considered a substance that has a mental effect (improving the metabolism of nerve cells).

Piracetam acts on some neurotransmitters such as acetylcholin, noradrenalin, dopamin ... changing neurotransmitter and contributing to improving the metabolic environment so that the neuron cells work well.

Piracetam reduces the ability to converge platelet and in case of abnormal erythrocytes, the drug can cause red blood cells to restore deformation and ability to pass through capillaries. The drug has anti -vibration effect. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron and no effect of GABA.

pharmacokinetics

piracetam used by oral absorption quickly and almost entirely in the digestive tract. The peak concentration of plasma (40 to 60 micrograms/ml) appears 30 minutes after taking a dose of 2 grams.

The peak concentration in the cerebrospinal fluid is achieved after taking the drug 2 to 8 hours. Absorption of drugs does not change during long -term treatment.

Piracetam is distributed into all tissues and can be through the brain blood barrier, placenta and even the membranes used in the renal viagers. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe, dots, cerebellum and bottom core. The sale time is 4 to 5 hours in plasma and about 6 to 8 hours in cerebrospinal fluid. Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact.

So far, piracetam's metabolic has not been found, the metabolism of piracetam in the human body has not been well known. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine.

If the kidney failure, the selling time increases: In patients with complete renal failure and not recovering, this time is 48 to 50 hours.

Before taking Neustam hard capsules 400mg pymepharco treat muscle vibration, anemia (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Treatment of muscle vibration

The starting dose of 7.2 g/day, divided into 2 to 3 times/day. Depending on the response, every 3 to 4 days, an increase of 4.8 g per day for the maximum dose of 24 g/day.

Treatment with other anti -shaken drugs should be maintained at the same dose. Depending on the clinical benefits achieved, the dose should be reduced if possible.

Piracetam should be used continuously during treatment, but every 6 months should take measures to reduce or stop treatment under the dose reduction roadmap of 1.2 g every 2 days to prevent the possibility of sudden recurrence.

long -term treatment of physical and physical mental syndrome in the elderly (cognitive impairment, intellectual decline)

use the dose 1.2 to 2.4 g/day, depending on the case.

The dose may be up to 4.8 g/day in the first weeks.

Elderly people: Need to adjust the dose in the elderly with kidney function damage. When long -term treatment in the elderly, regular evaluation should evaluate creatinine to adjust the dose accordingly if needed.

Dosage adjustment in patients with liver and kidney failure (based on creatinine clearance)

Creatinine clearance is over 80 ml/min: using normal doses, divided into 2 to 4 times/day.

Creatinine clearance is 50 to 79 ml/min: Use 2/3 of the normal doses, divided into 2 to 3 times/day.

Creatinine clearance is 30 to 49 ml/minute: Use 1/3 of the normal dose, divided into 2 times/day.

Creatinine clearance is 20 to 29 ml/minute: take 1/6 normal dose, 1 time/day.

Do not use drugs if the clearinine clearance is below 20 ml/min.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Neustam often has unwanted effects (ADR) such as:

Common

Body: fatigue.

Body: dizziness, weight gain, weakness.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindicated Neustam in the following cases:

Patients with hypersensitivity to piracetam and piracetam derivatives or hypersensitivity to any ingredients of the drug.

brain bleeding.

Caution when used

Because piracetam is discharged through the kidneys, the sale time of the drug increases directly to the degree of renal failure and the clearance of creatinine.

Be careful when taking medication for people with renal failure.

Need to monitor the kidney function of people with this disease and elderly patients. Avoid stopping the drug suddenly in patients with muscle vibration due to the risk of seizures.

Piracetam has the effect of inhibiting platelet gathering, thus caution in patients with severe bleeding, patients at risk of bleeding such as stomach ulcers, patients with potential coagulation disorders, a sudden history of hemorrhage, patients undergoing large surgery including dental surgery, and patients taking anticoagulants or anti -platelets including Aspirin low -dose.

Using drugs for women during pregnancy and lactating

should not use piracetam for pregnant women and nursing mothers.

The effect of the drug on the ability to drive and operate machinery

The drug can affect the ability to drive and operate machinery due to having unwanted effects such as dizziness, agitation, headache, chicken sleep. Therefore, if you are taking medicine, you should be cautious when participating in these activities.

Medicinal interaction

Medicinal interaction may affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Can continue the classic treatment of alcoholic (vitamins and sedatives) in the case of a person with a vitamin deficiency or a strong agitation.

There has been a case of interaction between piracetam and thyroid essence when used simultaneously: confusion, stimulation and sleep disorders. In patients with prothrombin time, Warfarin has increased when using piracetam.

Storage

In a dry, cool place (under 30 ° C). Avoid light.

Other drugs

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