Newlevo Babiophar daily contraceptive pills (1 blister x 28 tablets)

Dosage form Tablet
Specifications Box of 1 blister x 28 tablets
Ingredient Levonorgestrel

Ingredient

Composition information	Content
Levonorgestrel	0.03mg

Uses

indications

Newlevo drug is indicated in the following cases:

Birth control pills: Use for breastfeeding women. The drug has the same effect as the same as it describes with progestogen in general, but is a stronger ovary inhibitor than Norethisteron. With endometrium, drugs change the proliferation phase due to estrogen to the period of secretion.

The drug increases the body temperature, creates hypopasses changes in the vaginal epithelium, relaxes the uterus smooth muscle, stimulates the development of mammary cysts and inhibits the pituitary gland. Like other progestogen, levonorgestrel has many metabolic effects; The drug may reduce the amount of high density lipoprotein (HDL) in the blood.

levonorgestrel is often used for contraception. The contraceptive effect of levonorgestrel can be explained as follows: The drug changes the cervical mucus, creating a barrier that prevents sperm movement into the uterus. The nesting process of the egg is prevented from the structural changes of the endothelium from the supply. There is evidence that suggesting that the function of the reduced Hoang The also contributes to the contraceptive effect.

contraceptive, levonorgestrel is used in the form of oral contraceptive oral contraceptive only progestogen or in combination with estrogen in oral contraceptive oral contraceptive. Levonorgestrel is also used in the form of a long -term contraceptive pills by placing it under the skin or placed in the uterus.

Dynamic pharmacokinetics

After taking Levonorgestrel quickly and completely in the gastrointestinal tract and not initially metabolized in the liver. Levonorgestrel's bioavailability is almost 100%. In serum, levonorgestrel linked to globulin mounted sex hormones (SHBG) and with albumin.

Levonorgestrel's most important metabolic path is oxygen, followed by an union. The speed of drug clearance may vary many times between individuals; Half of the lifetime elimination of the drug in a stable state is approximately 36 ± 13 hours. Levonorgestrel and metabolites excreted through urine and feces.

Levonorgestrel concentration in serum can inhibit ovulation of 0.2 micrograms/liter. When taken, the peak concentration appears after 1.1 to 0.4 hours. Drink 30 micrograms levonorgestrel with a peak concentration of 0.9 ± 0.7 micrograms /liter. The enzyme induction in the liver microsom such as rifampicin, phenytoin may increase the metabolism of contraceptive compounds with both estrogen and progestogen, so the blood treatment concentration of these compounds is reduced.

The gut of oral contraceptives can be affected by intestinal bacteria. In plasma, levonorgestrel can be associated with sulfate and glucuronic acid. These forms are excreted into the bile and then the intestines, here they can be hydrolyzed by bacterial bacteria and release primitive drugs, this form is re -absorbed into the circulation. Antibiotics inhibit this effect of bacteria, resulting in a decrease in plasma hormones.

Before taking Newlevo Babiophar daily contraceptive pills (1 blister x 28 tablets)

How to use

Take oral use.

Dosage

Take the beginning of the menstrual cycle. Take the tablet as directed by the arrow on the blister, take 1 capsule a day at the same time, drink without interruption during the time of contraception. The drug should be taken continuously even when bleeding or not. If so, a contraceptive method should be applied until the first 14 pills are taken.

If you forget to take 1 capsule, you need to take that capsule immediately when remembering, if late 3 hours should use a method of contraception for the next 14 days and still drink as usual.

If vomiting or diarrhea, the contraceptive effect is affected and also applies a method of contraception for women until the end of 14 days after stopping vomiting or diarrhea.

On the blister number from 1 - 28. When used, from 1 to 28. When forgetting to drink, determined how many members were forgotten.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Therefore, it is generally not required to treat overdose.

However, if the overdose is detected early within 1 hour and at a large dose that it is recommended to handle it, the stomach can be washed, or take an appropriate dose of ipecacuanha. No specific antidote and symptomatic treatment.

What to do when you forget 1 dose?

On the blister number from 1 - 28. When used, from 1 to 28. When forgetting to drink, determined how many members were forgotten.

Side Effects

When using Newlevo, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: headache, depression, dizziness.

Endocrine: edema, breast pain.

digestive: nausea.

Urinary - genital: bleeding (regular or prolonged bleeding and bleeding), amenorrhea.

Uncommon, 1/1000

Body: Change weight.

Neurological: Reduce sex.

Endocrine: Sweating, sweating, bald.

Instructions on how to handle ADR

The most unwanted effect in Levonorgestrel is menstrual disorders (about 5%). Continuing to use medication, menstrual disorders decrease.

erratic vaginal bleeding when using levonorgestrel can cover the symptoms of cervical cancer or endometrial cancer, so it is necessary to periodically (6 -12 months) gynecological examination to eliminate cancer.

Oter of ectopic pregnancy occurs more in women who use oral contraceptives with only progestogen. This risk may increase when using levonorgestrel long and often in people with weight gain. In women who are taking levonorgestrel, they are pregnant or calling the abdominal pain under the physician, which should be alert about the possibility of ectopic pregnancy. Any patient who complains of the lower abdominal pain must be examined to eliminate ectopic pregnancy.

It is found that when using levonorgestrel or oral contraceptive pills, the risk of thrombosis increases. In drug users, that risk increases about 4 times compared to non -drug -free people. When users of drugs have intravenous inflammation or clogged thrombosis, the drug must be stopped.

In women who have to be in a long -term motional state due to surgery or other diseases, they also have to stop the drug. If the visual loss is partially or completely, gradually or suddenly; Or appear protruding eyes, looking at a couple, gai thorn, intense headache must stop the drug immediately.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Newlevo drug is contraindicated in the following cases:

Pregnancy or suspicion of pregnancy.

Abnormal vaginal bleeding does not diagnose the cause.

Venous inflammation or thrombosis of the activity.

Acute liver disease, healthy or malignant liver tumor.

breast carcinom or a history of the disease.

jaundice or persistent itching during the previous pregnancy.

Be cautious when using

levonorgestrel must be used carefully for seizures, valve disease, cerebral circulatory disease and for people with an increase in the risk of ectopic pregnancy, diabetes.

levonorgestrel can cause fluid, so when prescribing levonorgestrel must be carefully monitored in people with asthma, edema.

The ability to drive and operate machinery

There is no research on the effect of the drug on the ability to drive and operate the machine.

Pregnancy

progestogen used in high doses can cause masculinization of women's fetus. Although there are data on experimental animals, but on low -dose drug users, there is no problem. Wide studies show that the risk of birth defects does not increase in children whose mothers have used contraceptive drugs before pregnancy.

The period of breastfeeding

Progestogen only during breastfeeding is not harmful to children. If you start using 6 weeks after birth, the drug does not reduce the milk.

Drug interaction

liver enzyme induction such as barbiturat, phenytoin, primidon, phenobarbiton, rifampicin, carbamazepin and griseofulvin can reduce the contraceptive effect of levonorgestrel. For women who are taking liver enzyme drugs for long -term treatment, another contraceptive must be used.

Concentrated use of antibiotics can reduce the effects of the drug, due to interfering with the intestinal bacteria.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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