Newtop Sachet 100mg Maxim oral powder for infection treatment (10 packs x 1g)

Dosage form Box of 10 packs x 1g
Specifications Cefixim

Ingredient

Composition information	Content
Cefixim	100mg

Uses

indications

Newtop sachet 100 mg is indicated to treat bacterial infections caused by sensitive bacteria in the following cases:

Respiratory infections: pharyngitis, tonsillitis, acute bronchitis, acute batches of chronic bronchitis, otitis media, rhinitis. 3rd generation Cephalosporin is used by oral. In vitro, it has bactericidal effects on many types of gram -positive and gram -negative bacteria. The effect of cefixime is due to inhibiting the formation of bacterial cell membranes by attaching proteins attached to penicillin of bacterial cells. Cefixime has a high affinity for protein attached to penicillin and stabilizes in the presence of a variety of β - lactamase.

Cefixime has a clinical effect on bacterial infections caused by Streptococcus Pneumoniae, Streptococcus Pyogenes, Haemophilus Influenzae, Moraxella Catatrhalis, E.coli, Klebsiella spp., Salmonella and Proteus SPP. Cefixime is used to treat otitis media, respiratory tract infections, urinary tract infections, gonorrhea and other bacterial infections caused by sensitive bacteria.

Dynamic pharmacokinetics

about 40 - 50% of the amount of cefixime absorbed after oral, the amount of drugs absorbed regardless of food. However, the time to absorb the maximum amount of medicine will increase when used with food.

The peak concentration of cefixime in plasma is usually achieved after taking the drug 2-4 hours. The average peak concentration in the plasma of Cefixime depends on the dose, corresponding to 2.63 mg/l; 1.46 mg/l and 1.02 mg/l after taking a dose of 200 mg, 100 mg and 50 mg in healthy people.

Cefixime's waste sale time is 3-4 hours, longer than other oral active ingredients. Using Cefixime by oral route does not cause drug accumulation in plasma, except for patients with severe renal impairment. Patients with severe renal impairment have creatinine clearance

Before taking Newtop Sachet 100mg Maxim oral powder for infection treatment (10 packs x 1g)

How to use

The drug mixed with water and then drink, how to mix as follows: Cut the package of the drug along the dipping line and pour all the amount of medicine in the package into a glass. Pour water into the package. Pour water in the packet into the above glass cup. Stir well and drink immediately after mixing.

Dosage

Adults

The recommended dose is 200 - 400 mg of cefixime/day, taken once or divided into 2 times a day.

Urethritis and uncomplicated gonorrhea: The single dose of 400 mg.

Children

The recommended dose is 8 - 12 mg/kg/day, oral 1 time or divided into 2 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Because there is no specific treatment, it is mainly symptomatic treatment.

When there is an overdose symptom, stop immediately and handle as follows: Gastroentric lavage, anti -convulsions may be used if clinical indications. Because the drug is not eliminated by hemolysis, no dialysis or peritoneal filter.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Newtop Sachet 100 mg, you may experience unwanted effects (ADR).

Unwanted effect on Cefixime's digestive tract is more common than other antibiotics.

Common, ADR> 1/100

Digestive: diarrhea, loose stools or goes outside, abdominal pain, nausea, indigestion and flatulence.

Uncommon, 1/1000

Skin: Red rash, urticaria, itching.

nerve: headache, dizziness.

body: Fever. liver: Increase ALT, AST, ALP, LDH, Bilirubin, Bun.

Hematology: Against the platelet, leukocytes, neutrophils and eosin cells.

Testing: positive for Coombs test.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Newtop drugs 100 mg is contraindicated in the following cases:

Patients with hypersensitivity to penicillin or cephalosporin.

Be cautious when using

Caution when taking cefixime for patients with hypersensitivity to other drugs, especially penicillin.

Should stop the drug if the patient suspects having allergic reactions to Cefixime.

Need to be cautious and adjust the dose when taking cefixime for patients with renal failure.

Treatment with broad -spectrum antibiotics including Cefixime changes the normal microbiological system of the intestine and can cause excessive development of Clostridium in some patients.

There is no adequate and controlled research on the use of cefixime for pregnant women and children under 6 months old.

Hypersensitivity reactions (including shock and death) occurred in some patients when using Cefixime.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

Due to the lack of the safety of the drug with the fetus, need to be cautious when used for pregnant women.

The period of breastfeeding

Due to the unsafe safety of the drug for breastfed babies, need to be cautious when used for breastfeeding women.

Drug interaction

cefixime can increase the toxicity of the kidneys of Furosemide, Ethacrynate, Bumetanide, other diuretics, Carmustine, Streptozocin and aminoglycosides.

Clavulanic acid can increase the effect of cefixime on gram -negative bacteria.

Be cautious when using Cefixime simultaneously with warfarin.

Storage

Store in a cool dry place at a temperature of less than 30 ° C, avoiding light.

Other drugs

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