Nexipraz 40 Boston hard capsules treat gastroesophageal reflux disease (5 blisters x 7 tablets)

Dosage form Box of 5 blisters x 7 tablets
Specifications Esomeprazol

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

indications

Nexipraz 40 drugs are indicated in the following cases:

Gastroesophageal reflux disease. The drug has a specific inhibition effect in the cell wall.

Esomeprazol is a weak base, the drug is concentrated and transformed into an active form in a highly acidic environment in the submachine of the cell's secretion, where the proton inhibitors inhibit the basic fluid and the stimulating fluid.

The acid -secreting effect of the drug depends on the concentration of the drug in plasma and the time of contact with the drug.

Due to the inhibition of acid secretion, the drug has the effect of treating esophagitis due to gastroesophageal reflux - esophagus and gastric ulcer disease - duodenum due to H. pylori infection or prolonged anti -inflammatory drugs.

Dynamic pharmacokinetics

Esomeprazol is quickly absorbed, the peak concentration in plasma reaches about 1-2 hours after drinking. The biological use of the single dose of 40 mg is about 64%, increasing to 89% after the dose is repeated once a day. Esomeprazol is connected to plasma proteins about 97%.

Esomeprazol is completely metabolized through the Cytochrom P450 system to form hydroxy, desmethyl and esomeprazol sulphon metabolites.

Selling time for plasma is about 1.3 hours.

Esomeprazol is completely eliminated from plasma between doses, without the tendency to accumulate when used once a day. About 80% of oral doses are eliminated through urine in the form of metabolites, the rest through the feces. Less than 1% of the form of no metabolism is excreted in the urine.

Before taking Nexipraz 40 Boston hard capsules treat gastroesophageal reflux disease (5 blisters x 7 tablets)

How to use

Take oral, swallow the whole pill with drinking water, do not chew or crush the pill.

Dosage

Treatment of gastroesophageal reflux - ulcerative esophagus

Normal dose: 40 mg x 1 time/day, for 4 - 8 weeks.

Treatment of stomach ulcers - duodenum

In combination with antibiotics when there is H.pylori infection: Esomeprazol 40 mg x 1 time/day, amoxicillin 1 g x 2 times/day and Clarithromycin 500 mg x 2 times/day for 10 days.

Treatment of Zollinger - Ellison syndrome

The recommended starting dose is: 40 mg x 1 time/day.

Next, adjust the dose 80 - 160 mg/day according to the response of each patient, with a dose> 80 mg should be divided 2 times/day.

No need to adjust the dose with the elderly but should be cautious with people with impaired liver and kidney function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The symptoms described when taking the dose of 280 mg are symptoms on the gastrointestinal tract and fatigue.

There is no specific antidote. Overdose treatment by symptomatic treatment and supportive measures. It is not equal to the hemorrhage due to a strong drug associated with plasma proteins.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Nexipraz 40, you may experience unwanted effects (ADR).

The undesirable effects of Esomeprazol are not related to the dose.

Common effects: headache, abdominal pain, constipation, diarrhea, nausea ...

Little effects: Peripheral edema, insomnia, dizziness, paresthesia, chicken sleep, dry mouth, liver enzyme, rash, dermatitis ...

Rare effects: leukopenia, platelet reduction, hypersensitivity reactions, hypoglycatrological reduction, blurred vision, bronchospasm, stomatitis, hepatitis, muscle pain, joint pain ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nexipraz 40 drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Simultaneously used with Atazanavir.

Patients with severe liver failure.

Children under 12 years old.

Be cautious when using

before treatment with Esomeprazol must eliminate the possibility of malignant tumor because it can cover or reduce symptoms, thus delaying the diagnosis.

Patients treated for a long time (over 1 year) should be monitored regularly.

When prescribing the treatment regime when needed, the interaction of Esomeprazol must be taken into account with other drugs.

The ability to drive and operate machinery

No report.

Pregnancy

does not have enough clinical data, so it is cautious when used for women during pregnancy.

The period of breastfeeding

There has been no research conducted in breastfeeding women, so do not use medication for women during breastfeeding.

Drug interaction

Esomeprazole reduces the absorption of ketoconazol, iTraconazol.

Esomeprazol increases the area under the curve of Cisaprid concentration in plasma to 32%, extending the sale time by 31% but does not increase the peak concentration significantly.

Esomeprazol in combination with drugs such as Diazepam, citalopram, imipramin, clomipipin, phenytoin ... can increase the concentration of these drugs in plasma.

Should carefully monitor when shared Esomeprazol with warfarin and cooumarin derivatives, especially when starting and ending treatment.

Clarithromycin inhibits Esomeprazol metabolism that makes Esomeprazol level double.

Storage

Where dry, less than 30 ° C, avoid light.

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