Nexium 10mg nuggets Astrazeneca treat gastroesophageal reflux - esophagus (28 packs)

Dosage form Box of 28 packs
Specifications Esomeprazole

Ingredient

Composition information	Content
Esomeprazole	10mg

Uses

indications

Nexium 10mg drug is indicated in the following cases:

Children from 1-11 years old

Treatment of gastroesophageal reflux disease (GERD)

Treatment of esophageal scratches due to reflux is determined by laparoscopy.

Treatment of symptoms of gastroesophageal reflux disease (GERD).

Children 4 years and older

Combined with antibiotics in the treatment of duodenal ulcer caused by Helicobacter pylori.

The oral chemical NEXIUM can also be used for patients with difficulty dispersing disperse fluid of anti -gastric nexium tablets. For indications for patients 12 years of age and older, please see the prescription information of nexium tablets tablets.

Pharmacokology

Esomeprazol is the isomorphic form S-Omeprazol and reduces the secretion of stomach acid with a specialized mechanism at a special destination. The drug is a specific inhibitor of acid pumping in the wall of the wall. Both types of isomers R-and S- of Omeprazol have similar pharmacological effects.

Esomeprazol is a weak, concentrated and transformed basic into a high acidic environment in the sub-control tube of the cell's secretion, where H+K+K+-atpase inhibitors (Acid pump) and inhibit both basic fluid and stimulation secretion.

pharmacokinetics

absorption:

Esomeprazol is easily destroyed in acid environments and is taken in the form of granules in the intestine. Esomeprazol is quickly absorbed with peak plasma concentrations reaching about 1-2 hours after drinking

Distribution:

Expected distribution integral in a healthy state is about 0.22 l/kg of body weight. Esomeprazol binds 97% to plasma protein.

Metabolism:

Esomeprazol is completely transformed through the cytochrom P450 (CYP). Other, CYP3A4, forming Esomeprazol Sulfon, the main metabolite in plasma.

About 80% of esomeprazol oral doses are excreted in urine in the form of metabolites, the rest through feces. Less than 1% of constant drugs found in urine.

Before taking Nexium 10mg nuggets Astrazeneca treat gastroesophageal reflux - esophagus (28 packs)

How to use

for 10mg dose: Put all the amount of medicine in the 10mg package into a glass containing about 15 ml of water .. stir until the nuggets are completely dispersed and leave for a few minutes to thicken. Stir again and drink for 30 minutes. Do not chew or crush nuggets. Rinse the cup with 15 ml of water to make sure to drink enough dose.

For patients who placed pipes through the nose or gastric catheter: Please see the user manual for instructions on how to mix and use.

Dosage

children from 1-11 years old, weight ≥ 10kg

Gastroesophageal reflux disease (GERD)

Treatment of esophageal scratches due to reflux is determined by endoscopy

Weight ≥10 to

Weight ≥20 kg: 10 mg or 20 mg once a day for 8 weeks.

Treatment of symptoms of gastroesophageal reflux disease (GERD): 10 mg once a day for 8 weeks.

dose> 1 mg/kg/day has not been studied.

Children 4 years and older

Treatment of duodenal ulcer caused by helicobacter pylori.

When choosing a combination therapy

Note: The above dose is only appropriate, it is necessary to consider the official guidance of the nation, the region and the locality about the resistance of bacteria, the treatment time (usually 7 days but sometimes up to 14 days), and the appropriate way to use antibacterial drugs. The treatment process should be monitored by health workers.

The recommended dose is:

View Table:

Children under 1 year of age

Experience treatment with Esomeprazol in children

adults and adolescents aged 12 and older

Dosage in patients 12 years of age and older please see the prescription information of NEXIUM MUPS PEOPLE PEOPLE.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The described symptoms related to the use of 280 mg dose are symptoms on the gastrointestinal tract and fatigue. Esomeprazol 80 mg single doses are still safe to use.

There is no specific detoxification. Esomeprazol is strongly connected to plasma proteins and therefore not easily separated.

In case of overdose, symptomatic treatment and use of general support measures.

What to do when you forget 1 dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose and continue the schedule of Nexium 10mg. Do not use double dose to compensate for missed dose.

Side Effects

When using Nexium 10mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: headache;

Digestive system: abdominal pain, constipation, diarrhea, bloating, nausea/vomiting.

Uncommon, 1/1000

Nervous system: dizziness, dizziness, paresthesia, chicken sleep;

Digestive system: dry mouth, increased liver enzymes;

Metabolic disorders and nutrition: peripheral edema;

Muscle and connective tissue system: hip fracture, wrist or spine;

Skin and subcutaneous tissue: Dermatitis, itching, rash, urticaria.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nexium 10mg drug is contraindicated in the following cases:

History of hypersensitivity to esomeprazol, benzimidazol group or other ingredients in the formula;

Do not use esomeprazol simultaneously with nelfinavir.

Caution when using

when there is any alarm symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting blood or black defecation) and when suspected or gastric ulcer should eliminate malignant diseases because Nexium 10mg treatment can reduce symptoms and delay diagnostic.

Patients with long -term treatment (especially those who have been treated for more than 1 year) should be monitored regularly. Long -term treatment is indicated for adults and adolescents (12 years or older).

Patients treated according to the regime when necessary should contact the doctor if there are symptoms that change in characteristics. Treatment according to the regime when necessary has not been studied in children and therefore is not recommended in this group of patients.

This drug contains sucrose and glucose. Patients with rare genetic problems such as fructose intolerance, glucose-galactose malabsorption or deficiency of sucrase-isomaltase should not be used.

Increased risk of gastrointestinal infections such as Salmonella and Campylobacter.

It is not recommended to simultaneously use Esomeprazol with Atazanavir (see interactive section). If there is no alternative, clinically closely monitored when increasing the dose of Atazanavir to 400 mg combined with 100 mg of ritonavir; Do not use more than 20 mg Esomeprazol.

Esomeprazol, as well as all other antacids, can reduce the absorption of vitamin B12 (cyanocobalamin) due to reduced gastric acid. This should be considered in patients with vitamin B12 deficiency or have the risk of reducing vitamin B12 absorption in long -term treatment.

Esomeprazol is CYP2C19 inhibitor. When starting or ending treatment with Esomeprazol, it is necessary to consider the risk of drug interaction with metabolic drugs through CYP2C19 (Clopidogrel) .. To be cautious, should not be used simultaneously Esomeprazol and Clopidogrel.

The risk of severe maggesi blood in patients treated with proton pump inhibitors (PPI) such as Esomeprazol for at least 3 months, and in most cases of using PPI for 1 year.

Serious symptoms of blood -blooded lower blood such as fatigue, muscle spasms, delirium, convulsions, dizziness and ventricular arrhyths may occur, but may be silently and not concerned. The majority of patients who have a magnesi hypoglycemia will progress well after the supplementation of Magnesi and stop ppi.

For patients expected to be treated for a long time with PPI or patients who have to use PPI along with digoxin or other drugs that can cause blood magam (such as diuretics), medical experts should consider checking the magnesi levels in the blood before starting treatment with PPI and periodic tests during treatment. Proton pump inhibitors, especially when used in high doses (more than 1 time) and for a long time (> 1 year), may increase the risk of hip fractures, wrist bones and spine, especially in elderly patients or when there is a presence of known risk factors.

Patients with osteoporosis should be cared for under the current clinical instructions and should be used enough vitamin D and calcium.

Interacts with tests: an increase in Chromographin A (CGA) level can interfere with the detection of endocrine nerve tumors. In order to avoid this intervention, it is advisable to stop treating with Esomeprazol for at least 5 days before quantifying CGA (see Pharmacoketic Resource).

The ability to drive and operate machinery

does not record any impact.

Pregnancy

There is no enough clinical data on the use of Nexium 10mg in pregnant women. Should be cautious when prescribing pregnant women.

The period of breastfeeding

There are no studies on breastfeeding women. Therefore, Nexium 10mg should not be used during breastfeeding.

Interactive drug

Studies on interactions are only done in adults.

Esomeprazol's impact on pharmacokinetics of other drugs

For drug absorption drugs dependent

The reduction of stomach acid when treated with ecomeprazol and other ppi may increase or decrease the absorption of drugs where the absorption depends on the stomach pH. Like other acid -reducing drugs, the absorption of drugs such as ketoconazole, otraconazole and erlotinib may decrease and the absorption of digoxin may increase during treatment with ecomeprazol. There are rare reports on Digoxin toxicity. However, it is necessary to be cautious when using high doses of Esomeprazol in elderly patients. Need to increase monitoring treatment with digoxin.

Omeprazole interacts with some protease inhibitors. It is unclear clinical importance and the mechanism of impact of the recorded interactions. Increasing stomach pH during treatment with omeprazole can lead to changes in the absorption of protease inhibitors. Another possible interactive mechanism occurs through inhibition of CYP2C19. For Atazanavir and Nelfinavir, the serum concentration has been recorded when used with omeprazol, so it is not recommended to simultaneously use these drugs.

Metabolic drugs through CYP2C19

Esomeprazol inhibits CYP2C19, the main enzyme metabolizes Esomeprazol. Therefore, when Esomeprazol is used with metabolic drugs with CYP2C19 such as Diazepam, Citalopram, Imipramin, Clomipramin, Phenytoin ..., the concentration of these drugs in plasma can increase and decrease the dose. This should be paid special attention when prescribing Esomeprazol according to the treatment regime when necessary.

Do not use simultaneously Esomeprazol and Clopidogrel.

Unknown mechanism

There have been reports on increased tacrolimus concentration in serum when used simultaneously to Esomeprazol.

Used with methotrexate increases methotrexate levels in some patients. Patients with high doses of methotrexate should consider stopping esomeprazole.

The effect of other drugs on pharmacokinetics of Esomeprazol

Esomeprazol is metabolized by CYP2C19 and CYP3A4. When using Esomeprazol simultaneously with a CYP3A4 inhibitor, Clarithromycin (500 mg, 2 times/day) increases the concentration of esomeprazol in serum. No need to adjust the dose of Esomeprazol regularly in these situations. However, the dose adjustment should be noted in patients with severe hepatic or long -term treatment. Long -term treatment is indicated in adults and adolescents (aged 12 years and older, see the specified section).

CYP2C19 or CYP3A4 induction drugs or both (such as rifampicin and st. John’s grass) can cause reduced serum ecomeprazol levels due to Esomeprazol metabolism.

Storage

No storage at temperatures above 30 ° C.

Use within 30 minutes after mixing.

Other drugs

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