Nexium mups 40mg Astrazeneca tablets treat gastroesophageal reflux - esophagus, stomach ulcers (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Esomeprazol

Ingredient

Composition information	Content
Esomeprazol	40mg

Uses

indications

Nexium mups 40mg is indicated in the following cases:

Adults

Nexium treat gastroesophageal reflux disease (gerd):

Treatment of esophageal scratches due to reflux.

Heals a duodenal ulcer contaminated with Helicobacter pylori.

Heals stomach ulcers caused by NSAID drugs.

Treatment of Zollinger Ellison syndrome.

adolescents 12 years and older

Nexium treat gastroesophageal reflux disease (gerd):

Treatment of esophageal scratches due to reflux. Extensive stomach acid with a specialized mechanism of action.

The drug is a specific inhibitor in the acid pump in the wall of the wall. Both types of R-and S-S- part of Omeprazole have similar pharmacological effects.

Esomeprazole is a weak base, focused and transformed into an active form in a high acidic environment in the dead sub-tip of the cell's secretion, where H+K+-atpase inhibitors and inhibit both basic fluid and stimulating fluid.

Dynamic pharmacokinetics

The drug is absolutely absolutely absorbed and absolutely used by 64% after taking a single dose of 40 mg and increases to 89% after the dose is repeated once a day.

97% connected drugs to plasma proteins. Esomeprazole is completely metabolized through the Cytochrome P450 (CYP) system, the main part depends on the polymorphic CYP2C19 enzyme, the rest is CYP3A4.

About 80% of esomeprazole oral doses are excreted in the urine in the form of metabolites, the rest through feces.

less than 1% of constant drugs found in urine.

Before taking Nexium mups 40mg Astrazeneca tablets treat gastroesophageal reflux - esophagus, stomach ulcers (2 blisters x 7 tablets)

How to use

Nexium mups 40mg film tablets for oral, swallowing whole tablets with liquid, should not chew or crush the pill.

For patients with difficulty swallowing, dispersion of drugs can be dispersed in half a glass of water -free water.

Do not use other liquids because the coating helps NEXIUM 40mg dissolved in the intestinal tract can be dissolved.

Stir until the pill is completely dispersed and disperse the disperse fluid containing this micro -seed immediately or within 30 minutes. Rinse with half a glass of water and drink. Do not each other or crush these micro -micro.

For patients who cannot be swallowed, can be dispersed in carbonate without carbonate and through the gastric catheter.

Dosage

Dosage in case of treatment of gastroesophageal reflux disease (GERD):

Treatment of esophageal scratches due to reflux: 40 mg, 1 time/day for 14 weeks. The appropriate bacteria to eradicate Helicobacter pylori: Dosage 40 mg, 1 time/day for 4 weeks.

The recommended starting dose is 40 mg, 2 times/day. Then adjust according to the response of each patient. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The described symptoms related to the use of 280 mg are gastrointestinal symptoms and fatigue.

There is no specific detoxification. In case of overdose, symptomatic treatment and use of general support measures.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the forgotten dose and continue the schedule of Nexium 40mg. Do not use double dose to compensate for missed dose.

Side Effects

When using Nexium Mups 40mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurology: headache.

Digestive: abdominal pain, constipation, diarrhea, bloating, nausea/vomiting.

rarely, 1/1000

Metabolism, nutrition: peripheral edema.

Mental: Insomnia.

Neurological: dizzy, paresthesia, chicken sleep.

ears and mesmerizing: dizziness.

Digestive: dry mouth.

Skin, subcutaneous tissue: Dermatitis, itching, rash, urticaria.

Bone muscle, connective tissue: hip fractures, wrists and spine.

rare/very rare, ADR

Hematology: leukopenia, thrombocytopenia, grain leukocytes, all bloody hematoma.

Immune: Hypersensitivity reactions such as fever, angioedema, anaphylaxis/anaphylactic reaction.

Metabolism, nutrition: reducing blood sodium.

Mental: agitated, confused, depressed, impatient, hallucinations.

Neurological: taste disorders.

Eyes: blurred vision.

Respiratory: bronchospasm.

Skin, subcutaneous tissue: baldness, light sensitivity, diverse roses, Stevens - Johnson syndrome, poisoned epidermal necrosis.

Bone muscle, connective tissue: joint pain, muscle pain, muscle weakness.

Urinary kidney: interstitial nephritis.

Reproduction, mammary gland: female mammary glands.

Overview: Difficult to stay, increase sweating.

Instructions on how to handle ADR

When experiencing side effects of Nexium, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nexium mups contraindicated in the following cases:

Hypothesis hypersensitivity to Esomeprazole, Benzimidazole or other ingredients in the formula.

Do not use Esomeprazole simultaneously with Nelfinavir, Atazanavir.

Be cautious when using

when there is any alert symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting blood or black defecation) and when suspected or stomach ulcer should eliminate malignant diseases because treatment with Nexium MUPS can reduce symptoms and delay diagnostic.

Esomeprazole, as well as other antacids, can reduce the absorption of vitamin B12.

There have been reports on severe blood magnesium reduction in patients treated with proton bomb inhibitors for at least 3 months and in most cases in 1 year.

Proton pump inhibitors, especially when high doses and long -term (> 1 year) can slightly increase the risk of hip fractures, wrist bones and spine, especially in elderly patients or when there is a presence of other risk factors.

The ability to drive and operate machinery

Esomeprazole has little impact on the ability to drive and operate machinery. Some adverse reactions such as dizziness (rare), blurred (rare) vision may occur. If these adverse reactions occur, patients should not drive and operate machinery.

pregnancy

does not have enough clinical data on the use of Nexium Mups on pregnant women. Should be cautious when prescribing pregnant women.

The period of breastfeeding

It is unknown whether esomeprazole is secreted through breast milk or not. Therefore, Nexium Mups should not be used during breastfeeding.

Drug interaction

The reduction of stomach acid when treated with Esomeprazole and other PPIs can reduce or increase the absorption of other drugs with the absorption mechanism for stomach pH such as Ketoconazole, Itraconazole, Erlotinib and Digoxin.

There has been reported that Omeprazole interacts with some protease enzyme inhibitors. Due to the pharmaceutical effects and similar pharmacokinetic properties of Omeprazole and Esomeprazole, it is not recommended to use Esomeprazole simultaneously with Atazanavir and contraindicated using Esomeprazole simultaneously with Nelfinavi.

Esomeprazole is a CYP2C19 inhibitor: It is necessary to consider the risk of drug interaction with metabolic drugs through CYP2C19 such as diazepam, citalopram, clomipramine, phenytoine ...

There has been an interaction that holds Clopidogrel and Esomeprazole: Do not encourage the two above drugs.

Concomitance Esomeprazole has been reported to increase serum concentration of Tacrolimus.

When using simultaneously PPIs, methotrexate levels are reported to increase in some patients. When using high doses of methotrexate, it is recommended to temporarily pause Esomeprazole.

Storage

Do not store at temperatures above 30 ° C. Store in the original packaging to avoid moisture.

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