Nicomen 5mg Standard Chem and Pharm tablets treat angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Nicorandil

Ingredient

Composition information	Content
Nicorandil	5mg

Uses

Indications

Nicomen 5mg drug is indicated in the following cases: Treatment angina .

Pharmacological

nicorandil impact by relaxing blood vessel muscles, especially intravenous systems. Nicorandil does this through two different paths, first, by activating potassium channels, and then providing nitric oxide to activate the enzyme Ganylate Cyclase. GMP Activation GMP leads to veins and arteries.

Due to the selective effect on blood vessels, Nicorandil has no significant impact on the spasm of and myocardial transmission. Although Nicorandil can relax a healthy coronary coronary artery, little effect on the coronary artery of a person with myocardial infarction because blood vessels are ready to fully relax. Instead, Nicorandil relaxes the venous system, reduces the amount of blood to the heart and reduces the work of the heart.

pharmacokinetic

absorption

Nicorandil is well absorbed, without the first metabolism through the liver. The drug reaches a maximum concentration in plasma 30-60 minutes and is directly related to the dose.

Distribution

Nicorandil mounting ratio with low plasma proteins.

Metabolism

Metabolism is mainly through nitrate reducing.

Elimination

About 20% of the dose is discharged in urine in the form of metabolism. The sale time is about 1 hour.

There is no significant change in pharmacokinetics in the elderly or patients with liver or chronic kidney failure.

Before taking Nicomen 5mg Standard Chem and Pharm tablets treat angina (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults

Starting 10mg x 2 times/day or 5mg x 2 times/day for patients who are prone to headache. Then the dose will be adjusted gradually depending on the clinical response.

The usual dose is 10 - 20mg x 2 times/day.

The maximum dose is 30mg x2 times/day.

Elderly

No need to reduce the dose in the elderly. Like all other drugs, the lowest dose should be effective.

Children

The drug is not recommended for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? If necessary, increase the volume of circulatory plasma by appropriate infusion. In life -threatening cases, the use of vascular contractions can be considered.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using nicomen 5mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Headache fleeting at the beginning of treatment.

dizziness , nausea, vomiting.

Skin vasodilation causes blushing.

Feeling weak.

Uncommon, 1/1000

Increase heart rate when using high doses.

Rare, 1/10000

Pressure - silk or ulcers in the mouth for a long time.

Liver dysfunction.

Red rash.

muscle pain.

Very rare, ADR

Thich.

Gastrointestinal ulcer.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nicomen 5mg drug contraindicated in the following cases:

Heart shock, left ventricular failure, reducing blood pressure.

sensitive to nicorandil.

Simultaneously used with phosphodiesterase inhibitors 5 (Sildenafil, Tadalafil, Vardenafil).

Precautions when using

should avoid using nicorandil in patients with lack of blood volume, low systolic blood pressure, acute pulmonary edema or acute myocardial infarction with left ventricular ventricular and blood pressure to low heart.

Nicorandil's treatments can lower blood pressure of hypertension, so, as well as other anti -angina drugs, Nicorandil should be used cautiously when prescribed simultaneously with antihypertensive drugs.

There have been reports on gastrointestinal ulcers, mucosal ulcers when using Nicorandil.

Should consider replacing drugs when patients with pressure - silk or severe mouth ulcer.

The gastrointestinal perforation is also reported when taking nicorandil simultaneously with corticosteroids. So be careful when combining these drugs.

Nicorandil must be carefully used in patients with reduced blood volume or patients with acute pulmonary edema.

The ability to drive and operate machinery

Warning patients should not drive or operate machinery until they know their operations are not affected by Nicorandil.

Pregnancy

Animal studies do not show the harmful effects of nicorandil in the fetus, although there is no human experience. Do not use for pregnant patients unless no option is safer.

Breastfeeding period

whether Nicorandil does not know whether or not to produce breast milk or not, should be avoided for breastfeeding patients.

Medicinal interaction

There is no pharmacokinetic or pharmacokinetic interaction with beta receptor blockers, digoxin, rifampicin, cimetidine, acenocomarol, anti -calcium anti -Calcium or coordination of digoxin and furosemide in humans or animals. However, nicorandil is likely to increase the effect of lowering blood pressure of vasodilators, 3 -round antidepressants or alcohol.

Because of the hypotension effect of nitrate or nitric oxide suppliers increased by phosphodiesterase inhibitors 5, contraindicated use Nicorandil with phosphodiesterase inhibitors 5.

Storage

Store less than 30 ° C, avoiding light. To be out of reach of children.

Other drugs

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