Nidal Ampharco skin anti -inflammatory and osteoarthritis (30g) gel (30g)

Dosage form Box 1 tube x 30g
Specifications Ketoprofen

Ingredient

Thành phần cho 15g

Composition information	Content
Ketoprofen	375mg

Uses

Indication

Anti -inflammatory and analgesic drugs, used on the skin on the treatment of acute and chronic pain due to rheumatism, trauma, as well as postoperative pain including osteoarthritis, muscle tendon, sprain, ligament and edema.

Pharmacology

nidal gel contains ketoprofen, a derivative of phenyl propionic acid, not belonging to the steroid group with anti -inflammatory and analgesic properties.

Ketoprofen inhibits prostaglandin and platelet training.

Dynamic pharmacokinetics

Gel -like skin.

The concentration of tissue and in the plasma of Ketoprofen has been caused by over 24 patients underwent knee surgery. After repeating the ketoprofen gel is applied, the plasma concentration is 60 times lower (9-39 ng/g) compared to the concentration achieved in plasma when taking single dose ketoprofen (490-3300 ng/g). The concentration of tissue in the topical area when using the skin gel is also in the same concentration range when taken orally, although the level of changing the concentration of the gel is significantly higher between individuals.Ketoprofen's bioactivity after applying the skin is estimated to reach about 5% compared to oral use based on excreted data through urine.

About 99% of the drug associated with plasma proteins.

Ketoprofen is excreted through the kidneys mainly in the form of glucuronid complex.

Before taking Nidal Ampharco skin anti -inflammatory and osteoarthritis (30g) gel (30g)

How to use

Use on the skin, apply the head or inflammation, massage slightly and carefully for a few minutes to make sure the drug is absorbed through the skin. Wash your hands after applying the drug. Close the lid of the medicine tube after each use.

Dosage

Adults: Apply gel 2-3 times daily in pain or inflammation. The gel mass should be adjusted to cover the pain. Do not use more than a total dose of 15g/day. Do not use more than a week.

What do

do when using overdose? If used randomly, the gel may cause side effects depending on the amount of gel.

However, if overdose occurs, symptomatic treatment should be treated and supported as NSAID overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that double dose should not be used.

Side Effects

On -site skin reaction has been recorded, then can spread outside the topical area, and in some cases, it may be worse and body movements. Special cases have a whole body side effects, such as the kidneys, which have also been recorded.

Uncommon: local skin reactions such as redness, eczema, itching, feeling like burns. Some more severe reactions such as bullous, or eczema can spread, rarely occur systemic manifestations.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

History of disease with light sensitive reactions. Fish, skin infection, or open wound.

In the last three months of pregnancy.

Be cautious when using

should use the form of gel to apply carefully in patients with impaired heart, liver and kidney function.

Avoid applying the drug in the form of iron.

Do not apply the drug on the mucosa as well as the eye.

Immediately stop treatment when there is any skin reaction, including skin reactions when applied with products containing octocrylen.

Should protect the skin with a fabric during use and 2 weeks after stopping treatment to avoid the risk of light sensitivity. Should wash your hands carefully after applying the drug.

Do not prolong the treatment time due to the risk of dermatitis due to contact and sensitive reactions to light increases over time.

Safety and effectiveness of ketoprofen in children has not been determined.

The effect of the drug on driving and operating machinery

unknown.

Use drugs for women during pregnancy and lactation

pregnancy and lactation

No clinical experience for topical gel, reference information based on the form of systemic sugar:

during pregnancy

In the first six months of pregnancy, the safety of ketoprofen on pregnant mothers has not been evaluated, should avoid using Ketoprofen during this time.

During the last three months of pregnancy, all prostaglandin synthesis inhibitors including ketoprofen can be toxic to the heart, lungs and kidneys of the fetus. At the end of pregnancy, blood flow in the mother and child may last.

Therefore, contraindicated use of ketoprofen in the last three months of pregnancy.

During breastfeeding

There is no data on the excretion of ketoprofen in breast milk. Ketoprofen should not be used during breastfeeding.

Drug interaction

drug interactions cannot occur due to serum concentration after low skin use.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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