Nizastic 150mg Medisun hard capsules treat stomach - duodenal ulcer (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Nizatidine

Ingredient

Composition information	Content
Nizatidine	150mg

Uses

Indications

Nizastic 150 drug is indicated in the following cases:

Stomach - duodenal ulcer. Learning

nizatidin inhibits competition with the effect of histamine in the H2 receptor of the cells into the stomach, reduces the excretion of gastric acids all day and night, even when stimulated by food, histamine, pentagastrin, caffeine, insulin. Nizatidine receptor resistance is reversible. Inhibiting the excretion of gastric acid due to stimulation of nizatidine is similar to ranitidine and is 4-10 times stronger than cimetidine. After taking a dose of 300 mg nizatidin, gastric acid excretion at night is inhibited 90%, lasting up to 10 hours and excreting stomach acid due to irritation because food is inhibited 97% for up to 4 hours. Depending on the dose, nizatidin also indirectly reduces pepsin secretion due to reducing the volume of gastric acid excretion.

Nizatidine inhibitors for gastric acid excretion are not accumulated and drug -resistant, nor fast growing. The majority of studies think there is no phenomenon of increased gastric acid excretion after completion of treatment in people with duodenal ulcer. Nizatidine causes increased excretion of intrinsic factors stimulated by Betazol. The drug can protect the stomach lining, against the irritation effect of some drugs (such as NSAIDs ...).

Nizatidin does not work much to the serum concentration of gastrin, gonadotrophin, prolactin, growth hormone, anti -urinary hormone, cortison, testosterone, 5 - α - dihydrotestosteron or estradiol.

pharmacokinetic

absorption

Nizatidin absorbs fast, easy and almost completely through the gastrointestinal tract, so bioavailability when drinking about 70%, can increase slightly as food and mitigate when there is antacids but this change is not clinically. When using intravenous sugar, the effect of inhibiting gastric acid excretion starts within 30 minutes. Time and level of inhibition of gastric acid excretion due to nizatidine depends on the dose, maximum inhibition with oral doses of 300 mg.

Distribution

Nizatidine attaches about 35% to plasma protein, the distribution volume is 0.8 - 1.5 liters/kg in adults. Nizatidin passes the placenta and is distributed into breast milk. It is unknown whether nizatidin can enter the cerebrospinal fluid or not, although most of the H2 receptor anti -receptor drugs through the blood - brain barrier.

Metabolism

nizatidin metabolizes partially in the liver, in metabolites with N - 2 - monodesmethylnizatidin has about 60% of the activity of nizatidin.

Elimination

Selling time is about 1-2 hours, almost no age due to age, but prolonged kidney failure. In patients with normal kidney function, over 90% of oral doses of nizatidin eliminate through the urine within 12 - 16 hours, about 60 - 65% in the form of non -metabolic. Under 6% of the oral dosage of nizatidin is eliminated in feces.

Before taking Nizastic 150mg Medisun hard capsules treat stomach - duodenal ulcer (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults:

Stomach ulcer - duodenum: 2 capsules/day/day in the evening, in 4 - 8 weeks.

benign stomach ulcers: 2 capsules/day/day in the evening, in 4 - 8 weeks.

Treatment of maintaining duodenal ulcers in low doses to reduce recurrence after the ulcer has healed: 1 tablet/time/day in the evening.

Gastroesophageal reflux disease: 1-2 tablets/time x 2 times/day for 12 weeks.

Stomach ulcer and/or duodenum due to simultaneous use of NSAID groups: 2 tablets/time/day in the evening or 1 tablet/time x 2 times/day (in the morning and evening).

Patients with medium renal failure:

Stomach ulcer - duodenum: 1 tablet/time/day in the evening.

benign stomach ulcer: 1 tablet/time/day in the evening.

Treatment of maintaining duodenal ulcer with low doses to reduce recurrence after the ulcer has healed: 1 tablet/time/day, drinking day.

Gastroesophageal reflux disease: 1 tablet/time x 2 times/day.

Stomach ulcer and/or duodenum due to simultaneous use of NSAID groups: 1 tablet/time/day in the evening.

Patients with severe kidney failure:

Stomach ulcer - duodenum: 1 tablet/time/day, drinking day.

benign gastric ulcer: 1 tablet/day/day, drinking day.

Treatment for maintaining duodenal ulcer with low doses to reduce recurrence after the ulcer has healed: 1 tablet/time/day, drink 3 days.

Gastroesophageal reflux disease: 1 tablet/time/day, drinking daily or every day.

Stomach ulcer and/or duodenum due to simultaneous use of NSAID groups: 1 tablet/time/day, drinking day.

Children:

Not used for this object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? It is unknown the dosage of nizatidin in humans.

In vivo, nizatidin overdose with cholinergic symptoms including: tearing, saliva, vomiting, pupils, diarrhea.

There is no specific antidote, only symptomatic treatment and support. Reduce absorption by causing vomiting, gastric lavage, activated carbon.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Nizastic 150, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: rash, itching, peeling dermatitis.

Respiratory: cough, runny nose, sore throat, sinusitis.

musculoskeletal: back pain, chest pain.

Uncommon, 1/1000

Skin: urticaria.

digestive: abdominal pain, diarrhea, constipation, dry mouth, vomiting. Systemic: Fever, bacterial infection, hyperuricemia.

Rare, ADR

Skin: Diverse pink, hair loss, poisoning epidermal necrosis.

Blood: Anemia, leukopenia, thrombocytopenia, full hemorrhage. Cardiovascular: Arrhythmic (tachycardia or slow heart), posture hypotension, atrial block - ventricle, fainting. Hypersensitivity: Anaphylaxis, angioedema, laryngeal edema, bronchospasm, vasculitis. liver: hepatitis, jaundice, cholestasis, hyper enzyme.

Mental: restlessness, hallucinations, confusion, dizziness, fatigue, insomnia, headache. Endocrine: Reduce sexual ability, big breasts in men.

musculoskeletal: muscle pain, joint pain.

Eye: visual disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nizastic 150 drugs are contraindicated in case of hypersensitivity to H2 receptor anti -receptors or any components of the drug.

Be cautious when using

before using nizatidine to treat stomach ulcers, eliminating cancer likely because the drug can cover symptoms and slow down the diagnosis of cancer.

Patients with hypersensitivity to one of H2 receptor resistant drugs may also be crossed with other drugs in H2 antihistamine group.

Be cautious, reduce the dose and/or extend the distance between drug use in people with renal failure (CLCR Consider the risk/benefits when used in people with cirrhosis or liver failure (may have to reduce the dose or prolong the distance between drug use).

Be cautious in people with starch allergies.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

nizatidin passes through the placenta. Studies using nizatidin in pregnant women are incomplete, so only use the drug when necessary and according to the doctor's advice.

In rabbits, with the dose of nizatidin, equivalent to 300 times the dose on the body has caused miscarriage, reducing the amount of fetus, reducing the weight of pregnancy.

Breastfeeding period

nizatidin excreted into breast milk, which can cause serious ADR in breastfed babies. The mother should stop breastfeeding during medication or stop taking medicine.

Medicinal interaction

The effect of inhibiting the excretion of gastric acid at night of H2 receptor resistant drugs may be reduced by tobacco. People with stomach ulcers should stop smoking or at least avoid smoking after taking the last dose of the day.

Avoid using alcoholic beverages.

Unlike cimetidine, nizatidin does not inhibit cytochrome P450, so it has little impact on the metabolism of other drugs. However, like H2 receptor anti -receptor drugs, nizatidine increases gastric pH, so it can affect the absorption of some other drugs.

can reduce the absorption of H2 receptor drugs when used simultaneously with antacids. Do not take any antacids within 1 hour after taking H2 receptor.

Pipelonus (chloramphenicol, cyclophosphamide ...) with H2 receptor resistant drugs can increase neutropenia or hematopoietic disorders.

Take H2 receptor anti -receptor drugs for at least 2 hours after taking otraconazole, ketoconazole due to H2 receptor resistant drugs increase the gastric pH, significantly reducing the absorption of these two drugs.

Nizatidine may increase serum salicylate concentration when used with high doses of acetylsalicylic acid.

Sucralfate reduces the absorption of H2 receptor anti -absorption drugs, must take two drugs apart at least 2 hours apart.

Storage

In a dry place, avoid light, below 30 ° C

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