Nizoral Cool Cream Janssen skin treatments for skin fungal infections, tinea versicolor (5g)

Dosage form Tube
Specifications Ketoconazole

Ingredient

Composition information	Content
Ketoconazole	20mg

Uses

indications

Nizoral® Cool Cream is indicated for use on the skin on the skin in the following cases:

Treatment of skin fungal infections: Fungal infections in the body; Fungal infections in the inguinal; Fungal infections in the hands and feet are caused by Trichophyton rubrum, Trichophyton mentagrophytes, microsporum canis and epidermophyton floccosum, as well as in the treatment of candidiasis in the skin and treat tinea.

The treatment of seborrheic dermatitis caused by Malassezia Furfur.

Pharmacokology

Medicinal pharmacological groups: Topical antifungal antifungal, Imidazol and triazol.

Mechanism of action

Ketoconazole inhibits Ergosterol biosynthesis in mushrooms and changes the structure of other lipid components in the membrane.

Pharmacological effect

Ketoconazole cream usually works very quickly on itchy symptoms, which are commonly seen in skin and yeast mushrooms as well as in skin diseases related to the presence of Malassezia spp. Realizing this symptom is improved before seeing the first signs of healing.

Microbiology

Ketoconazole, a synthetic Imidazole derivative, has a strong antifungal activity for leather mushrooms such as Trichophyton spp., Epidermophyton Flocosum and Microsporum spp. And for yeasts, including Malassezia spp. and Candida spp. Especially effective on Malassezia spp. Very obvious.

Dynamic pharmacokinetics

For adults, after applying Nizoral Cool Cream on the skin, there is no ketoconazole in plasma.

In a study in young children with seborrheic dermatitis (n = 19), for about 40 g of Nizoral Cool Cream per day over 40% of the skin surface area, ketoconazole has been detected in plasma from 32-13 ng/ml in 5 children.

Before taking Nizoral Cool Cream Janssen skin treatments for skin fungal infections, tinea versicolor (5g)

How to use

use on the spot, apply on the skin.

Dosage

Candida infections in the skin, fungal infections in the body; Fungal infections in the inguinal, fungal infections in the hands and tinea versicolor: Nizoral Cool Cream are recommended to apply skin once a day in areas with fungal infections and adjacent skin areas.

Footed fungus: Nizoral Cool Cream is recommended 2 times a day to the skin infected with the normal treatment time for mild infection for 1 week. For severe or widespread fungal infections (for example, fungal infections on one leg or both legs) therapy should continue one and the day after all symptoms disappear to avoid recurrence.

Seborrheic dermatitis: Apply Nizoral Cool Cream to areas infected with fungus 1 or 2 times daily depending on the weight of the lesion.

The usual treatment time is: 2-3 weeks for tinea versicolor, 2-3 weeks for yeast infections. 2-4 weeks for fungal infections in the groin. 3-4 weeks for fungal infections in the body.

The time for treating seborrheic dermatitis is 2-4 weeks. Treatment is maintained by applying drugs 1 or 2 times per week in seborrheic dermatitis.

Therapy should be continued for a few days after all the symptoms disappear. It is advisable to review the diagnosis if not clinically improved after 4 weeks of treatment. Should follow good hygienic measures to control infections or re -infections.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Applying too much medicine on the skin can cause erythema, edema and hot feeling, these symptoms will be lost when stopping the drug.

Swallow into the mouth

In case of unintentional swallow, it is necessary to take supportive measures and symptomatic treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Nizoral® Cool Cream, you may experience unwanted effects (ADR).

Clinical test data: The safety of Nizoral Cool Cream has been evaluated through 1079 subjects in 30 clinical trials when using Nizoral Cool Cream topical.

Common, ADR> 1/100

Systemic disorders and the condition of the drug: Red rash, itching.

Skin and subcutaneous tissue disorders: burning sensation, skin burns.

Uncommon, 1/1000

Systemic disorders and the condition of topical places: bleeding where the drug is applied, uncomfortable at the top of the drug, dry skin where the drug is applied, irritated where the drug is applied;

Immune system disorders: Hypersensitivity;

Skin and subcutaneous tissue disorders: puffiness, contact dermatitis, rash, peeling skin, oily skin.

Rare, ADR

No report.

After -sales data

rarely

Skin and subcutaneous tissue disorders: urticaria.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Nizoral® Cool Cream is contraindicated in the following cases:

Do not use Nizoral Cool Cream in people who are too hypersensory to any ingredients of the drug.

Be cautious when using

do not use Nizoral Cool Cream in the eye.

If simultaneously used with topical corticosteroids, to prevent the backward phenomenon occurs when stopping topical topical corticosteroids after a long time of treatment, continue to use a mild corticosteroid topical in the morning and use Nizoral Cool Cream in the evening and then gradually reduce the dose and then stop Costicosteroid topical for 2-3 weeks.

Nizoral Cool Cream contains propylene glycol: can cause skin irritation.

Nizoral Cool Cream contains Cetyl alcohol and Stearyl alcohol: These ingredients can cause skin reactions such as contact dermatitis.

The ability to drive and operate machinery

No data.

Pregnancy

There is no enough research on pregnant women. Testing in non -pregnant people, after applying Nizoral Cool Cream to the skin, there is no ketoconazole concentration in plasma. The risks have not been determined related to the use of Nizoral Cool Cream in pregnant women.

The period of breastfeeding

does not have enough research information in nursing women. The risks have not been determined related to the use of Nizoral Cool Cream in nursing women.

Interactive drug

unknown.

Storage

Storage below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.