Nizoral Jassen ice cream 20mg/g treat skin fungal infections (15g)

Dosage form Cream
Specifications Box
Ingredient Ketoconazole

Ingredient

Composition information	Content
Ketoconazole	20mg/g

Uses

Indications

Nizoral cream to treat skin fungal infections: Fungal infections in the stem (squint, ringworm), Fungal infections, fungal infections in hands and feet caused by Trichophyton Rugbrum, Trichophyton Mentagrophytes, Microsporum Canis and Epidermophyton Flocosum, treatment of Candida Fungal infections and treatment of skin treatment.

Nizoral ice cream is also indicated in the treatment of seborrheic dermatitis - a skin disease associated with the presence of Malassezia Furfur mushrooms.

Pharmacokology

ketoconazole, an Imidazole dioxolant derivative, strong antifungal activity for skin fungi like Trichophyton sp., Epidermophyton Flocosum and Microsporum SP. And for yeasts, including Malassezia spp. and Candida spp. Especially effective on Malassezia spp. Very prominent.

ketoconazole inhibits Ergosterol biosynthesis in mushrooms and changes the structure of other lipid components of the membrane.

Ketoconazole usually works very quickly on itchy symptoms, which are common in skin and yeast fungal infections as well as in skin diseases related to the presence of Malassezia spp.

Symptoms are reduced before seeing the first signs of healing.

Dynamic pharmacokinetics

For adults, after applying 2% nizoral on the skin does not produce a concentration that can be detected in blood. In a study in children with seborrheic dermatitis (n = 19), for about 40g of Nizoral cream per day over 40% of the skin surface area, detects Ketoconazole blood concentration in 5 children, at 32-133 ng/ml.

Clinical safety data

There is no special risk detection for humans based on the results of skin irritation evaluation research, dermatitis and skin toxicity when used repeated.

Acute research on skin and eye irritation with Ketoconazole formula on rabbits shows no skin or eye irritation. The results from a study of skin sensitivity in mice showed that there was no potential for allergies or sensitivity. During the year research on rabbits, Ketoconazole was used for both skin scratched and not scratched at a maximum dose of 40 mg/kg. In a study of some light skin irritation recorded in both ketoconazole and placebo groups, however, in the remaining studies, there is no case of skin reaction or toxic effect. Data from pharmacokinetics studies, some external formulas of ketoconazole under testing conditions in experimental animals, shows no ketoconazole concentration in plasma.

Before taking Nizoral Jassen ice cream 20mg/g treat skin fungal infections (15g)

How to use

Apply Nizoral cream at infected areas.

Dosage

Candida fungal infection in the skin, infected in the body (squint, ringworm); Fungal infections in the inguinal; Fungal infections in hands and tinea versicolor:

Apply nizoral cream once a day in areas infected with fungal and adjacent skin.

Common treatment time:

tinea: 2 - 3 weeks.

Yeast infection: 2 - 3 weeks.

Apply nizoral cream once a day in infected areas and adjacent skin areas for 4-6 weeks, or apply nizoral cream twice a day in areas infected with fungal and adjacent skin for 1 week.

Seborrheic dermatitis:

Apply Nizoral cream in infected areas and areas near 1 or 2 times daily depending on the severity of the lesion.

The treatment time for seborrheic dermatitis is usually 2-4 weeks. Treatment is maintained by applying medicine 1-2 times per week.

Therapy should be continued enough, at least a few days after all the symptoms disappear. Diagnosis should be reviewed if not clinically improved after four weeks of treatment. General hygiene measures should be monitored to check the sources of infection or re -infection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? These symptoms will be lost when stopping the drug.

Swallow into the mouth:

In case of unintentional swallow, it is necessary to take supportive measures and evaluate symptoms.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The safety of Nizoral ice cream has been evaluated through 1079 subjects in 30 clinical trials when using Nizoral cream on the skin.

Adultery effects when treating individuals with Nizoral cream as ≥1% of users:

General disorders and status where applied:

Red Red Red Area: 1.0%.

Itching place: 2.0%.

A burning sensation, skin burns: 1.9%.

General disorders and status where applied:

bleeding.

sensitive.

Skin and subcutaneous tissue disorders:

bullous rash.

contact dermatitis.

The first adultery was determined during the use of Nizoral ice cream on the market, the frequency is calculated in the ratio as follows:

Very common: ≥ 1/10, common: ≥ 1/100 and

Adultery effects are presented at frequency based on the proportion in clinical trials or known epidemiological studies.

Skin and subcutaneous disorders:

Unknown: urticaria.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Nizoral cream is contraindicated in the following cases:

Do not use Nizoral cream in people who are too hypersensitivity to any ingredients of the drug.

Be cautious when using

Do not use Nizoral cream in the eye.

To prevent the backward phenomenon occurring when stopping topical corticosteroids after a long time of treatment, it is recommended to continue using topical corticosteroids in the morning and use Nizoral cream in the evening and then decrease gradually and then stop corticosteroids within 2 - 3 weeks.

The effect of the drug on the ability to drive and operate machinery

unknown effects of the drug.

Use drugs for women during pregnancy and lactation

do not have enough research on pregnant and lactating women. Testing in non -pregnant people, after applying 2% nizoral cream to the skin, there is no ketoconazole concentration in plasma. Therefore, the risks have not been identified related to the use of Nizoral cream for pregnant and lactating women.

Drug interaction

drug interactions can affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Please see more information about drugs in the instructions for the use of drugs attached.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C. No storage in refrigerators or freezing.

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