Niztahis 300 Agimexpharm treat duodenal ulcer, benign stomach ulcers, gastroesophageal reflux disease, esophagus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Nizatidine

Ingredient

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Composition information	Content
Nizatidine	300mg

Uses

indications

Niztahis 300 drug indicated in the following cases:

duodenum ulcer.

benign stomach ulcer. Management: H2 receptor antagonistic drugs

ATC code: A02BA04

Nizatidin inhibits competition with the effect of histamine in the H2 receptor of the cells into the stomach wall, reduces the excretion of gastric acids day and night, even when stimulated by food, histamine, pentagastrin, caffe, insulin. Nizatidine receptor resistance is reversible. Inhibiting the excretion of nizatidin stimulation is similar to ranitidine and is 4-10 times stronger than cimetidine. After taking a dose of 300 mg nizatidin, gastric acid excretion at night is inhibited 90%, lasting up to 10 hours and excreting stomach acid due to irritation because food is inhibited 97% for up to 4 hours. Depending on the dose, nizatidin also indirectly reduces the excretion of pepsin due to reducing the volume of gastric acid excretion.

Nizatidine inhibitors for gastric acid excretion are not accumulated and greasy does not grow quickly. The majority of studies think there is no phenomenon of increased gastric acid excretion after completion of treatment in people with duodenal ulcer. Nizatidine causes increased excretion of intrinsic factors stimulated by Betazol. The drug can protect the gastric mucosa, against the irritation of some drugs (such as nonsteroidal anti -inflammatory drugs).

Nizatidin does not have much effect on the serum concentration of Gastrin, gonadotrophin, prolactin, growth hormone, anti-urinary hormone, cortison, testosteron, 5-a-dihydrotestosteron or estradiol.

Pharmacokinetics

absorption

Nizatidin absorbs fast, easy and almost completely through the gastrointestinal tract, so bioavailability when drinking about 70%, can increase slightly when the food is present and decrease slightly when the presence of antacids but this change is not clinically. Use intravenous sugar, inhibiting the excretion of gastric acid begins within 30 minutes. Time and level of inhibition of gastric acid excretion due to nizatidine depends on the dose, maximum inhibition with oral doses of 300 mg.

Distribution

Nizatidine attaches about 35% to plasma proteins, the distribution volume is 0.8 - 1.5 liters/kg in adults.

nizatidin passes the placenta and is distributed into breast milk. In a medication study for nursing mothers, about 0.1% of oral dose found in breast milk. It is unknown whether nizatidin can enter the cerebrospinal fluid or not, although most of the H2 receptor anti -receptor drugs through the blood - brain barrier.

Metabolism

Nizatidin metabolizes a small part of the liver, the metabolites have been identified as: Nizatidin N-2-Oxyd, Nizatidin S-Oxyd, N-2-Monodesmethylnatidin, in which N-2-MonodesmethylniZatidin has about 60% active of nizatidine.

Elimination

Half life eliminates about 1-2 hours, almost no age affected by age, but prolonged kidney failure. In patients with normal renal function, over 90% of oral doses of nizatidin eliminate through urine within 12-16 hours, about 60-65% in non-metabolic form. Under 6% of the oral dosage of nizatidin is eliminated in feces.

Before taking Niztahis 300 Agimexpharm treat duodenal ulcer, benign stomach ulcers, gastroesophageal reflux disease, esophagus (3 blisters x 10 tablets)

How to use

Niztahis 300 drug used oral, taking pills with 1 cup of water.

Dosage

adults:

duodenal ulcer: Daily recommendations are taking 300 mg in the evening. Treatment should continue for four weeks, although this time can be reduced if the ulcer is healed with endoscopy. Most ulcers will heal for four weeks, but if the ulcer is not completely healed after four weeks of treatment, patients should continue to treat another four weeks.

benign stomach ulcers: daily recommendations are taking 300 mg in the evening for four weeks or if necessary, eight weeks. Before nizatidine treatment, be careful to eliminate stomach cancer.

Gastroesophageal reflux disease: Take 300 mg once at bedtime up to 300 mg twice a day. Treatment for up to 12 weeks is indicated for inflammation, ulcers and heartburn.

Stomach ulcer and/or duodenal ulcer associated with the simultaneous use of nonsteroidal anti -inflammatory drugs: Daily recommendations are taking 300 mg daily before going to bed for up to 8 weeks. In most patients, the ulcer will heal for 4 weeks. During treatment, the use of nonsteroidal anti -inflammatory drugs can continue.

Elderly: Age does not significantly affect effectiveness or safety. Usually do not need to adjust the dose except for patients with moderate to severe renal failure (creatinine clearance below 50 ml/min).

Children: The safety and effectiveness of nizatidin in children has not been determined. No data.

Patients with renal failure: For medium renal impairment patients (creatinine clearance below 50 ml/min) or severe renal failure (creatinine clearance below 20 ml/min) without using Niztahis 300 due to inappropriate dosage, these patients use Niztahis 150 tablets under the dose adjustment instructions for people with kidney failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? It is unknown the dosage of nizatidin in humans.

Overdose: In animals, overdose nizatidin with cholinergic symptoms including: watery eyes, saliva secretion, vomiting, pupils, diarrhea.

Management:

There is no specific antidote, only symptomatic treatment and support.

Reduce absorption: Causes vomiting, gastrointestinal, drinking activated carbon. Hematoparoa does not eliminate nizatidin.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The harmful reactions are grouped by frequency: very common (ADR ≥ 1/10), common (1/100 ≤ ADR

Nizatidin has very little or no anti -antrogen effect, although there are a few notifications about large breast and sexual reduction in men. Nizatidine also does not affect the level level of prolactin and does not affect the clearance of the liver of other drugs. Nizatidine ADRs on the heart are less than other H2 receptor anti -receptors.

Common

Skin: rash, itching, peeling dermatitis.

Skin: urticaria. Hyper uric acid hyperkemis.

Rare

Systemic: dizziness, fatigue, insomnia, headache. Anaphylaxis, veins, laryngeal edema, bronchospasm, vascular inflammation sense.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Niztahis 300 drug is contraindicated in the following cases:

Hypersensitivity to H2 or hypersensitivity drugs with any ingredients of the drug.

Be cautious when using

before using nizatidine to treat stomach ulcers, eliminating cancer likely, as the drug can cover symptoms and slow down the diagnosis of cancer.

Cross -sensitive hypersensitivity: Patients with hypersensitivity to one of the H2 receptor drugs may also be sensitive to other drugs in H2 histamine resistance group.

Use carefully and reduce the dose and/or extend the distance between drug use in people with renal failure (CLCR Consider the risk/benefits when used in people with cirrhosis or liver failure (may have to reduce the dose or prolong the distance between drug use).

Safety and effectiveness of nizatidin for children under 12 years of age has not been proven.

This drug contains lactose. Patients with rare genetic metabolic disorders in galactose tolerance, lactase deficiency lactase or Glucose-Galactose absorption disorders should not use this drug.

The effect of the drug on the ability to drive and operate machinery

because the drug causes dizziness, fatigue, insomnia, headache carefully driving and operating machinery when using the drug.

Use drugs for women during pregnancy and lactation

Pregnancy:

nizatidin passes the placenta. Studies using nizatidin in pregnant women are incomplete, so they only use the drug when necessary and according to the physician's advice.

Research on mice and rabbits at a dose of up to 1500 mg and 275 mg/kg/day (40.5 and 14.6 times the dose for people based on body area, corresponding), there is no sign of poisoning effects on pregnancy.

Women who are likely to be pregnant or are using contraception should consult a doctor carefully before treatment with this drug.

breastfeeding period:

nizatidin excreted into breast milk, which can cause serious ADR in breastfed babies. The mother should stop breastfeeding during medication or stop taking medicine.

Interactive drug

Tobacco: The effect of inhibiting the excretion of gastric acid at night of H2 receptor resistant drugs can be reduced due to smoking. People with stomach ulcers should stop smoking or at least avoid smoking after taking the last H2 receptor drug doses of the day.

Alcohol: Avoid using alcoholic beverages.

Unlike cimetidine, nizatidin does not inhibit cytochrom P450, so it has little impact on the metabolism of other drugs. However, like other H2 receptor drugs, due to increased gastric pH, it can affect the absorption of some other drugs.

Anti -acid drugs: Concomitance with H2 receptor resistant drugs can reduce the absorption of H2 receptor drugs. Advise patients not to take any antacids within 1 hour after taking H2 receptor.

Portumes of myelosuppression: chloramphenicol, cyclophosphamide ... use the same H2 receptor resistant drug, which can increase neutropenia or other hematopoietic disorders.

iTraconazole or ketoconazole: significantly reduces the absorption of these two drugs due to H2 receptor resistant drugs increase the gastric pH, so it is necessary to take H2 receptor drugs at least 2 hours after Itraconazole or Ketoconazole.

salicylate: Nizatidin can increase the concentration of Salicylate serum when simultaneously used with acetylsalicylic acid.

Sucralfat: Reducing the absorption of H2 receptor drugs, taking two drugs must be at least 2 hours apart.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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