NO-SPA 40mg Sanofi medicine for smooth muscle spasms, gallbladder stones, gallstones (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Drotaverine

Ingredient

Composition information	Content
Drotaverine	40mg

Uses

Indications

What effect does NoSpa have? NO - Spa indicated treatment in the following cases:

Drotaverine is a medication for spasms derived from smooth muscle.

Smooth muscle spasms are related to biliary diseases:

Due to gallbladder stones, gallbladder stones, cholecystitis, cholecystitis, bile tract infection and pancreatitis.

Due to kidney stones, ureteral stones, pyelonephritis, cystitis and bladder spasm.

Abdominal pain or abdominal cramps due to gastrointestinal muscle spasms: spasms in stomach-colon, gastritis, mental spasms and pylons, small intestinal inflammation and colitis, colitis with constipation and abdominal distention due to irritated colon syndrome. Drotaverine improves quickly and effectively symptoms of spasms but does not cover surgical abdominal signs.

Medicine group for treatment: Smooth muscle dilatation drug group is indicated for treatment of pain syndrome of various organs such as digestive system, biliary tract, urinary system - genital and blood vessels.

Drotaverine is the derivative of isoquinoline, which has anti -muscle spasms due to the inhibition of phosphodiesterase enzyme (PDE) IV (PDEs of AMP ring) in the laboratory but does not inhibit ISOENZYM PDE III and PDE V.

PDE IV inhibitors have muscle dilatation and anti -inflammatory activity.

The consequences of PDE IV inhibitors increase the in intracellular amp levels by the Kinase enzyme duct ductoring of the mild myosin chain (MLCK) and calcium ions (Ca2+) intracellular reduction leading to smooth muscle relaxation.

Functional, PDE IV proved to have a very important role in reducing the spasm of smooth muscle, this shows that the selective inhibition of PDE IV can be helpful in the treatment of dyslemen-caused disorders and diseases related to spasms of the digestive system, ureter-sex system.

The enzyme hydrolyzes in the heart muscle and blood vessel muscle cells are mainly isoenzyme PDE III, which explains that Drotaverine is an effective anti -spasms but does not have an unexpected effect on the heart, and has high treatment effect on the heart.

The drug works in the case of smooth muscle spasms of both nerves and muscles.

The impact of Drotaverine on the smooth muscles of the digestive system, biliary tract, urinary-sex system and blood vessels does not depend on the distribution of plant nervous systems on muscles.

Due to the effect of vasodilation, increasing tissue circulation.

Drotaverine is absorbed faster and more faster and more than papaverine, and cohesion with plasma proteins less than papaverine, so the effect of Drotaverine is stronger than the papaverine.

Drotaverine has no anti -anti -cholinergic effects.

pharmacokinetic

absorption

Drotaverine absorbs quickly after oral use. The peak concentration of plasma (CMAX) is reached about 45 to 60 minutes after drinking.

distribution

The volume of the father is about 200 liters. Drotaverine has a high cohesion rate with protein (95-98%), especially with albumin, Gama- and Beta-Globulin. Drotaverine can cross the placenta.

transformation

Drotaverine is metabolized in the liver. After the first metabolism through the liver, 65% of the oral dose is found in the form of unchanged in the circulatory system.

Elimination

Biological destruction time is 16-22 hours. In fact, the drug disappears completely from the body after 72 hours. More than 50% of the drug is excreted in the urine and about 30% in feces. The drug is excreted mainly in the form of metabolism; No metabolic format in urine.

Before taking NO-SPA 40mg Sanofi medicine for smooth muscle spasms, gallbladder stones, gallstones (5 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

recommended dose:

Adults: 120-240 mg/day (3-6 tablets divided 2-3 times/day).

Children: The use of Drotaverine in children has not been established in clinical studies; If using Drotuverine is necessary.

For children from 6 to 12 years old: the maximum daily dose is 80 mg (ie 2 tablets), divided into 2 times/day.

For children over 12 years of age, the maximum daily dose is 160 mg (ie 4 capsules/day), divided into 2-4 times/day.

There is no data for children under 6 years old.

What to do when overdose?

In case of overdose, rings should be closely monitored, symptomatic treatment and support care. Handling measures include vomiting and/or gastric lavage.

There is no data related to overdose. In the case of an overdose of the patient should be closely monitored and symptomatic treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

During the clinical research period, the following undesirable effects are reported related to Drotaverine by frequency groups: very common (> 1/10), common (> 1/100, 1/1,000, 1/10,000,

Disorders of the digestive system:

Rare: Nausea, constipation.

Nervous system disorders:

Rare: headache, dizziness, insomnia.

Cardiovascular disorders:

Rare: Brushing chest drum, lower blood pressure.

immune system disorders:

Rare: allergic reactions (angioedema, urticaria, rash, itching). If you record any side effects not mentioned in this user manual, immediately notify your doctor or pharmacist.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

NO - Spa contraindicated in the following cases:

Hypersensitivity to the main active ingredient or any excipients of the drug.

Caution when using

Special and cautious notes when using the drug.

Need to be more cautious when using Drotaverine in case of hypotension.

Due to lactose-containing drugs, patients with rare genetic disorders such as galactose intolerance, lactase enzyme deficiency or glucose-galactose are not used.

Using drugs for women during pregnancy and lactation

Before using any drug, it is necessary to be thought by the doctor or pharmacist.

Pregnant women

There is no evidence of monitoring and toxic to embryos from animal studies and recovery research in humans during pregnancy when taking the drug by oral. However, be cautious when indicated for drugs for pregnant women.

Women who are breastfeeding

Due to the lack of adequate survey results, the drug is not recommended during breastfeeding.

The effect of the drug on the ability to drive and operate machinery

Patients should be instructed that if they feel dizzy, they should avoid doing dangerous things like driving or driving machinery.

Drug interaction

When used with Levodopa, this drug reduces the anti -Parkinson, and increases tremor, muscle spasms.

Storage

Store at a temperature not exceeding 30 ° C.

To be out of reach of children.

Other drugs

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