NO-SPA Forte 80mg Sanofi Treatment of smooth muscle spasms, gallbladder stones, gallbladder stones (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Drotaverine

Ingredient

Composition information	Content
Drotaverine	80mg

Uses

Indications

NO - Spa Forte is indicated in the following cases:

Treatment of smooth muscle spasms in biliary tract diseases: gallbladder stones, gallbladder stones, gallbladder inflammation, gallbladder inflammation, cholecitis, pancreatitis. ( stomach and duodenal ulcer , gastritis, spasms and pylons, bowelitis, and increased irritation of the colon) and gynecological diseases (menstrual pain). The mechanism of action of the drug is due to the inhibition of phosphodiesterase enzymes (PDE) IV and increases the consequences of the Camp concentration, leading to smooth muscle relaxation through the inactivity of the kinase of the light myosin chain (MLCK).

Drotaverine inhibits PDE IV in vitro but does not inhibit isenzyme PDE Lii and PDE V.

In fact, PDE IV plays a very important role in the blockage of smooth muscle spasms, based on the selective inhibition of PDE IV that can be applied in the treatment of dysfunction disorders and diseases with smooth muscle spasms.

Hydrolyzed Camp PDE Lii in the heart muscle and blood vessel muscles, which explains Drotaverine as effective anti -spasms without response reactions and does not have strong treatment effects on the cardiovascular system.

The drug works in all cases of smooth muscle spasms derived from nerves and muscles. Regardless of the type of automatic nerve distribution, Drotaverine acts evenly on the smooth muscles of the digestive system, biliary tract, urinary system - genital and blood vessel system. Due to vasodilators, drugs increase tissue circulation.

Drotaverine has a stronger effect, is faster and more complete, and is bound to less blood protein than papaverine. Another advantage of the drug is that the side effect of stimulating respiration is observed after using the injection papaverine that does not occur with Drotaverine.

pharmacokinetic

absorption

Drotaverine absorbs quickly and completely after oral or injection. The peak concentration of plasma is achieved within 45 - 60 minutes after drinking.

Distribution

Drotaverine has a high cohesion rate with plasma albumin (95 - 98%), gamma and beta - Globulin.

Metabolism

After passing the first metabolic cycle, 65% of Drotaverine oral dose into the circulatory system in the form of constant. Drotaverine metabolizes in the liver.

Elimination

Biological destruction time is 8 - 10 hours. In fact, the drug is no longer in the body after 72 hours, the post is about 50% in the urine and 30% in the feces. The drug is excreted mainly in the form of metabolic substances, unchanged in the form of drugs in urine.

Before taking NO-SPA Forte 80mg Sanofi Treatment of smooth muscle spasms, gallbladder stones, gallbladder stones (2 blisters x 10 tablets)

How to use

NO - Spa Forte Take oral.

Dosage

Normal dosage of No - Forte spa for adults is 1-3 tablets/day (divided into 2-3 times).

There is no clinical research on the use of NO - Forte Spa for children. If necessary, it is possible for children to use drugs over 1 to 1 to 2 tablets/day (divided into 1-2 times).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using NO - Spa Forte , you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

headache, dizziness, nausea and nausea, insomnia, constipation , lower blood pressure.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

NO - Spa Forte Contraindicated in the following cases:

Hypersensitivity to the active ingredient or any excipients of the drug.

Hepatic, kidney or heart failure.

Children ≤ 12 years old.

Caution when using

Note special attention when using NO - Spa Forte for patients with low blood pressure.

Due to the composition of the drug containing lactose (104mg), the drug can cause digestive disorders for patients with lactose intolerance.

The ability to drive and operate machinery

When taking the medication at the usual doses, Drotaverine does not affect the ability to drive and operate machinery. However, if you are dizzy after taking the drug, you should avoid dangerous situations such as driving or operating machinery.

Pregnancy

should consult a doctor or pharmacist before taking any medication.

Based on animal studies and in humans, when taking the drug during pregnancy, there is no report on harmful effects on the mother and the fetus. However, be cautious when indicated for drugs for pregnant women.

Breastfeeding period

Due to the lack of research data, should not take medicine for women who are breastfeeding.

Medicinal interaction

When used with Levodopa, No - Spa Forte reduces the anti -Parkinson's treatment effects, worsens muscle spasms and trembling.

Storage

Store drugs in original packaging at a temperature of not exceeding 30ºC.

Leave the pills away from the reach and vision of children.

Do not take the drug after the expiry date specified on the drug box.

Do not remove drugs through wastewater or household waste. Should ask the pharmacist about how to release drugs no longer need. These measures will help protect the environment.

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