No-Spa injection solution 40mg/2ml Sanofi anti-muscle spasm, treat gallbladder stones, gallstones (5 blisters x 5 pipes x 2ml)

Dosage form Box of 5 blisters x 5 tubes x 2ml
Specifications Drotaverine hydrochloride

Ingredient

Thành phần cho 2ml

Composition information	Content
Drotaverine hydrochloride	40mg

Uses

indications

No-Spa Inj injection solution is a smooth anti-spasm. NO-SPA drugs are used in the following cases:

Smooth muscle spasms in biliary tract diseases: gallbladder stones , gallbladder stones, cholecystitis, cholecystitis, bile tract infections, pancreatitis. Smooth muscle in the digestive tract: gastric and duodenal ulcer, gastritis, mental spasms and pylons, small intestinal inflammation and colitis The mechanism of action of the drug is due to the inhibition of phosphodiesterase enzymes (PDE) IV and the result is increasing the Camp concentration, leading to smooth muscle relaxation through the inactivity of the kinase of the mild Myosin chain (MLCK). Drotaverin inhibits PDE IV in vitro, but does not inhibit the enzymes with PDE IIL and PDE V.

PDE IV plays a very important role in closing the spasm of smooth muscle; Based on the selective inhibition of PDE IV, it can be applied in the treatment of hyperactivity disorders and diseases that are accompanied by smooth spasm of the digestive tract. PDE II Hydrolyzed Camp in the heart muscle and blood vessel muscle, which explains Drotaverin as effective anti -spasms without significant adverse reactions and has no strong treatment effects on the cardiovascular system.

The drug works in all cases of smooth muscle spasms derived from nerves and muscles. Regardless of the type of automatic neurological distribution, Drotaverin evenly acts on the smooth muscles of the digestive system, biliary tract, urinary system - genital and blood vessel system. Due to vasodilators, drugs increase tissue circulation.

Drotaverin has a stronger effect, is faster and more complete absorption, and is less cohesive with plasma proteins than papaverin. Another advantage of the drug is that the side effect of stimulating respiration is observed after using the injection papaverin that does not occur with Drotaverin.

pharmacokinetics

absorption:

Drotaverin absorbs quickly and completely after oral or injection.

Distribution:

Drotaverin has a high cohesion rate with plasma albumin (95-98%), gamma- and beta-globulin. The peak concentration of plasma is achieved within 45 to 60 minutes after drinking.

Metabolism:

Drotaverin is metabolized in the liver. After passing the first metabolism, 65% of the Drotaverin oral dose into the circulatory system in the form of unchanged.

Era:

The drug is no longer in the body after 72 hours, the post is about 50% in the urine and 30% in the feces. The drug is excreted mainly in the form of metabolites; No constant form of the drug in urine.

Before taking No-Spa injection solution 40mg/2ml Sanofi anti-muscle spasm, treat gallbladder stones, gallstones (5 blisters x 5 pipes x 2ml)

How to use

Inject it and only be injected by medical staff.

Dosage

The average daily dose used for adults is intramuscular (in muscle): 40-240 mg/day (divided into 1-3 times).

To reduce acute pain in the intestines or kidneys: intravenous injection (in veins): 40-80 mg/day.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In case of overdose, the patient should be closely monitored and symptomatic treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using No-Spa Inj drugs , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Pain of injection.

Uncommon, 1/1000

Neurology: headache , dizziness, nausea, and chest drums.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to the main active ingredient of the drug (Drotaverin) or any excipients of the drug (especially sensitive to disulfit).

Hepatic, kidney or heart failure.

Children.

Be cautious when using

need to be more cautious when taking this drug in case of low blood pressure.

Due to the risk of vascular collapse, intravenous only patients in the lying position.

Avoid injection in the case of patients allergic to disulfit.

The ability to drive and operate machinery

After the injection, especially intravenous injection, patients should avoid dangerous activities such as driving or operating machinery.

Pregnancy

should be cautious when indicated for drugs for pregnant women.

Breastfeeding period

Avoid use for breastfeeding women due to lack of data.

Drug interaction

When used with Levodopa, No-Spa Inj reduces the anti-Parkinson's treatment effect, such as worsening muscle spasms and trembling.

Storage

Store in a dry place, temperature below 30ºC, avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.