Novogyl Mekophar medicine to treat dental infections, gingivitis (2 blisters x 10 tablets)

pharmacokinetics

Spiramycin is absorbed inadequate in the digestive tract and widely distributed throughout the body, the peak concentration in plasma is achieved within 2-4 hours after drinking. Spiramycin metabolizes the liver into active metabolites and is excreted mainly through bile.

Metronidazole is often absorbed quickly and completely after drinking. Metronidazole diffuses well into tissues and fluids, converted in the liver into hydroxy and acid -shaped metabolites, excreted through urine partially in the form of glucuronic. The half -life of Metronidazole in plasma is about 8 hours.

When high doses, can cause digestive disorders: nausea, vomiting, diarrhea. Can encounter long QT range, gradually stopping treatment.

Treatment: In case of an overdose, an electrocardiogram should be used to measure the QT interval, especially when there are other risks (reducing potassium, congenital QTC interval, combining the drug that extends the QT and/or causing torsion). There is no antidote. Symptomatic treatment.

metronidazol

Metronidazol overdose when taking a single dose of 15g has been reported. Symptoms include: nausea, vomiting, loss of air conditioning, peripheral neuropathy, epilepsy.

Handling: There is no specific antidote. Symptomatic treatment and support.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do if you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that double dose should not be used.

Unwanted effect depends on the dose.

Common, ADR> 1/100:

Precautions when using

should be cautious when used for patients with liver dysfunction, when combined with warfarin.

Need to reduce the dose in people with severe liver failure.

Stop therapeutic during the loss of air conditioning, dizziness or mental disorders.

The drug can aggravate the nerve state in people with the disease in the central nervous system or severe, stable or progressive peripheral system.

Monitor leukemia formulas in people with a history of blood disorders or high and prolonged doses.

Metronidazol has the effect of inhibiting alcohol Dehydrogenase and other alcohol oxidation enzymes. The drug has a mild disulfiram -style reaction such as hot face, headache, nausea, vomiting, abdominal spasms and sweating. Do not drink alcohol, alcoholic beverages during medication.

Metronidazole can cause immobility of Treponema Pallidum to create a false positive reaction of the Nelson test.

Each Novogyl tablet contains about 100 mg of lactose, need to be cautious when used for patients with rare genetic disorders in galactose tolerance, lactase lactase deficiency or glucose - galactose absorption disorders.

Preparations containing PonCeau 4r color can cause allergies in some sensitive people.

Using drugs for women during pregnancy and lactation

Avoid taking the drug in the first 3 months of pregnancy because Novogyl can pass the placenta.

Do not take medicine in women who are breastfeeding or stop breastfeeding while taking the drug.

Pregnant women, nursing women should consult a doctor before use.

The effect of the drug on the ability to drive and operate machinery

The drug can cause dizziness, headache, cautiousness when used for train drivers and operate machinery.

Medicinal interaction

spiramycin

using Spiramycin simultaneously with oral contraceptive drugs will cause loss of conception effect.

Spiramycin reduces the concentration of levodopa in the blood if used simultaneously.

Spiramycin is small or does not affect the cytochrom paso enzyme system in the liver, so Spiramycin has little interaction with drugs metabolized by this enzyme.

metronidazol

When using Metronidazol with:

Coumarin anticoagulants: Metronidazol can increase the effect of anti -blood dynamic oral dynamic drugs, especially warfarin that extends prothrombin time, so avoid simultaneous use or must monitor prothrombin time or adjust the dose of anticoagulants if needed.

Alcohol and drugs contain alcohol: Metronidazole inhibits alcohol oxidation enzymes and Dehydrogenase alcohol causes disulfiram reaction. Therefore, do not drink alcohol or simultaneously use alcoholic drugs during treatment with metronidazol. Do not simultaneously use metronidazol with disulfiram or medication must be used at times apart.

Phenobarbital: Increases metronidazol metabolism so the drug is faster.

Lithi: There have been a report on some toxic signs of lithium when taking Metronidazol for patients who are treating high -dose lithiums because they can cause increased serum lithium concentration, thus need to be cautious and
monitor lithium concentration when used simultaneously.

Terfenadin and Astemisol: Metronidazol can interact with terfenadin and astemisol when used simultaneously increasing the serious adverse reaction on the heart of these drugs such as extending the QT, arrhythmia, tachycardia ... so it must be very cautious and should not be used simultaneously these anti -histamine drugs for patients who are taking ITRACONAL, KETCONAL, KETCONAL Metronidazol.

cimetidine inhibits the metabolism in the liver of Metronidazol, increasing the sale time of metronidazol, leading to an increase in unwanted effects, so it is necessary to consider when used simultaneously.