Novomycine 3 M.u Mekophar Treatment of respiratory, skin and genital infections (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Spiramycin

Ingredient

Composition information	Content
Spiramycin	3000000iu

Uses

indications

Novomycine 3 M.IU is indicated in the following cases:

Treatment of cases of respiratory, skin and genital infections caused by bacteria sensitive to spiramycin . Acute rheumatism in patients with allergies to penicillin. The mechanism of action of the drug is the effect on the subuniters of 50S of bacterial ribosom and prevent protein synthetic bacteria. In serum concentrations, the drug has the main effect of bacteria, but when it reaches high concentrations, the drug can kill bacteria slowly for sensitive bacteria.

Macrolid drug resistance is often related to the process of changing the destination position of the drug. The anti -drug mechanism can be intermediaries or plasmid. The anti -drug bacteria produce an adenin methylation enzyme in ribosom rna, resulting in inhibition of the cohesion of the drug with ribosom.

In places where the drug level is very low, Spiramycin has a resistance to Gram -positive strains, coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75% Streptococcus and Enteroccus. The strains of Bordetella Perussis, Corynebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive to Spiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has also been a notice of bacterial resistance to spiramycin, including cross resistance between Spiramycin, erythromycin and oleandomycin.

Pharmacokinetics

absorption

Spiramycin is not completely absorbed from the digestive tract and is reduced when used with food. Oral dose is absorbed about 20-50%. Food reduces about 70% of the maximum concentration of the drug in serum and makes the peak time from 2 hours later than when they are hungry.

Distribution

After drinking 6 million ĐVQT SPIRAMYCIN, the plasma peak concentration is 3.3 micrograms/ml after 1.5 - 3 hours. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. The drug does not go through the blood -brain barrier, but through the placenta and the breast milk.

Metabolism

Spiramycin metabolizes the liver into active metabolites.

Elimination

Half life eliminates about 5 - 8 hours. Mostly excreted through bile and about 10% into the urine. Spiramycin also deducted 1 part in the feces.

Before taking Novomycine 3 M.u Mekophar Treatment of respiratory, skin and genital infections (2 blisters x 5 tablets)

How to use

Take the medicine before meals for at least 2 hours or after 3 hours of meals, swallow the whole pill with a full glass of water.

Dosage

recommended dose for adults:

Dosage: 6,000,000-9,000,000 IU/24 hours (2-3 tablets/day) divided 2-3 doses. Treatment time sore throat is 10 days.

Preventive meningitis caused by meningococcus: 3,000,000 IU/12 hours. Use for 5 days.

Patients with renal function impairment:

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

When high doses, it can cause digestive disorders : nausea, vomiting, diarrhea. Can encounter long QT range, gradually stopping treatment.

How to handle:

In case of an overdose, an electrocardiogram should be used to measure the QT interval, especially when there are other risks (reduced potassium, congenital QTC, combining the use of the drug extending the QT and/or causing torsion). There is no antidote. Symptomatic treatment.

Actively monitor for timely measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Novomycine 3 M.IU, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, indigestion .

Neurological: Dizziness, headache .

Uncommon, 1/1000

Body: fatigue, nosebleeds , sweating, chest pressing.

digestive: acute colitis. DA: BAN DA, NOM, urticaria .

Rare, 1/10000

Systemic: superinfection due to long -term use of spiramycin.

heart: extend the range of qt.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Novomycine 3 M.IU contraindicated in the following cases: people with a history of hypersensitivity to Spiramycin, or with other macrolid antibiotics, or any ingredients of the drug.

Be cautious when using

caution when using Spiramycin for people with liver dysfunction, because the drug can be toxic to the liver.

Be cautious for people with heart disease, arrhythmia (including people who tend to extend QT). When starting to treat if the body is fever, it is necessary to stop the drug because it is suspected of having pustules in the acute, this case must be contraindicated to use Spiramycin.

Be cautious when used for patients with renal failure, deficiency G6PD.

The ability to drive and operate machinery

The drug can cause unwanted effects such as dizziness, headache, so be cautious when used for drivers and operate the machine.

Pregnancy

Do not use Spiramycin for pregnant women, unless there are no replacement therapy and must be monitored very carefully.

The period of breastfeeding

Spiramycin is excreted through breast milk with high concentrations. Use carefully for breastfeeding women, should stop breastfeeding while taking the drug.

Interactive drug

using Spiramycin simultaneously with oral contraceptive medicine will lose the effect of conception prevention.

Spiramycin reduces the concentration of levodopa in the blood, if used simultaneously.

Spiramycin is small or does not affect the cytochrom P450 enzyme system in the liver; So compared to erythromycin, Spiramycin has less interaction with drugs metabolized by this enzyme.

There are many cases of increased activity of oral anticoagulants that have been reported when using Spiramycin antibiotics.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

Other drugs

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