Novomycine nuggets 0.75 M.u Mekophar Treatment of respiratory, skin and genital infections (20 packs x 3g)

Dosage form Box of 20 packs x 3g
Specifications Spiramycin

Ingredient

Composition information	Content
Spiramycin	750000iu

Uses

indications

Novomycine 0.75 M.IU is indicated in the following cases:

Treatment of cases of respiratory, skin and genital infections caused by spiramycin sensitive bacteria. Acute joints in patients with allergies to penicillin.

ATC code: J01FA02.

Spiramycin is an antibiotic group macrolid, which works on bacteria that are dividing cells. The mechanism of action of the drug is the effect on the subuniters of 50S of the bacterial ribisom and prevents protein synthetic bacteria. In serum concentrations, the drug has the main effect of bacteria, but when it reaches high concentrations, the drug can kill bacteria slowly for sensitive bacteria.

Macrolid drug resistance is often related to the process of changing the destination position of the drug. The anti -drug mechanism can be intermediaries or plasmid. Antibiotic -resistant bacteria produce an adenine methylation enzyme in ribosom rna, resulting in inhibition of the cohesion of the drug with ribosom.

In places where the drug level is very low, Spiramycin has a resistance to Gram -positive strains, coccus strains such as Staphylococcus, Pneumococcus, Meningoccus, most Gonococcus strains, 75% Streptococcus and Enteroccus. The strains of Bordetella Perussis, Coryenebacteria, Chlamydia, Actinomyces, some Mycoplasma and Toxoplasma strains are also sensitive toSpiramycin.

Spiramycin does not work with Gram -negative intestinal bacteria. There has also been a notice of bacterial resistance to spiramycin, including cross resistance between Spiramycin, erythromycin and oleandomycin.

Dynamic pharmacokinetics

Spiramycin absorbed completely from the gastrointestinal tract and reduced when used the same food. Oral dose is absorbed about 20-50%. Food reduces about 70% of the maximum concentration of the drug in serum and makes the peak time from 2 hours later than when they are hungry.

After drinking 6 million ĐVQT SPIRAMYCIN, plasma concentration is 3.3 micrograms/ml after 1.5-3 hours. Selling time is about 5-8 hours. The drug reaches high concentrations in the lungs, tonsils, bronchial and sinuses. The drug does not go through the blood -brain barrier, but through the placenta and the breast milk.

Spiramycin metabolizes the liver into active metabolites, mostly excreted through bile and about 10% into the urine. Spiramycin also excreted partially into the feces.

Before taking Novomycine nuggets 0.75 M.u Mekophar Treatment of respiratory, skin and genital infections (20 packs x 3g)

How to use

Take medicine before meals for at least 2 hours or 3 hours after meals.

Dosage

as directed by the doctor.

Recommended dose:

Patients with normal kidney function:

Children: 150,000-300,000 IU/per kg of body in the body/24 hours, divided 2-3 doses.

Surgery treatment time is 10 days.

Children 75,000 IU/per kg body weight/12 hours. Use for 5 days.

No dose adjustment.

Handling drugs before and after use:

There is no special requirement on drug treatment before and after use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

Overdose and treatment

Overdose:

When high doses, can cause digestive disorders: nausea, vomiting, diarrhea. Can encounter long QT range, gradually stopping treatment.

How to handle:

In the case of overdose, it is advisable to make electrocardiograms to measure the QT interval, especially when there are other risks (reduced potassium, congenital QTC, combining the drug that extends the QT and/or causing torsion). There is no antidote. Symptomatic treatment.

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using 0.75 M.UU Novomycine, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: Nausea, vomiting, diarrhea , indigestion .

Body: fatigue, nosebleeds , sweating, chest pressing.

Rare, ADR

Systemic body: superinfection due to long -term use of spiramycin oral drugs.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Novomycine drug 0.75 M.IU contraindicated in the following cases:

People with a history of hypersensitivity to spiramycin, or with other macrolid antibiotics, or any ingredients of the drug.

Be cautious when using

Precautions when using Spiramycin for people with liver dysfunction, because the drug can be toxic to the liver.

Caution for people with heart disease, arrhythmia (including people who tend to extend QT). When starting treatment, if you see a whole body with a fever, it is necessary to stop the drug because it is suspected of having a foreign acne, this case must be contraindicated to use Spiramycin.

Be cautious when used for patients with renal failure, deficiency G6PD.

The ability to drive and operate machinery

The drug can cause unwanted effects such as dizziness, headache, so be cautious when used for drivers and operate the machine.

Pregnancy

Do not use Spiramycin for pregnant women, unless there are no replacement therapy and must be monitored carefully.

The period of breastfeeding

Spiramycin is excreted through breast milk with high concentrations. Use carefully for breastfeeding women, should stop breastfeeding while taking the drug.

Interactive drug

using Spiramycin simultaneously with oral contraceptive medicine will lose the effect of conception prevention.

Spiramycin reduces the concentration of levodopa in the blood, if used simultaneously.

Spiramycin is small or does not affect the cytochrom P450 enzyme system in the liver; So compared to erythromycin , spiramycin less interactive with drugs metabolized by this enzyme system.

There are many cases of increased activity of oral anticoagulants that have been reported when using antibiotics.

Storage

Store in a dry place, avoid light, temperature not exceeding 300C.

Other drugs

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