Nuggets of Klamentin 500/62.5 DHG Pharma for respiratory infections (24 packs)

Dosage form 24 package box
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	62.5mg

Uses

indications

Klamentin 500/62.5 drugs are indicated for short -term treatment for upper and lower respiratory infections, urinary tract, skin and soft tissue, bone and joints. Klamentin has bactericidal properties for many bacteria including the beta - lactamase secretions resistant to ampicillin and amoxicillin.

Pharmacokology

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family with wide bactericidal spectrum for many gram -positive and gram -negative bacteria due to synthetic inhibition of bacterial cells. But because amoxicillin is easily destroyed by beta - lactamase, so Amoxicillin does not work for bacterial strains that produce these enzymes.

Clavulanic acid has a beta - lactam structure similar to penicillin, capable of inhibiting beta - lactamase due to the majority of Gram -negative bacteria and staphylococcus. In particular, clavulanic acid has a strong inhibition effect of beta - lactamase transmitted via plasmid that resists penicillins and cephalosporins.

The combination of clavulanic acid and amoxicillin in Klamentin 500/62.5 helps Amoxicillin not to be destroyed by beta - lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria that have been resistant to amoxicillin, resist other penicilins and cephalosporin.

The bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic type: Clostridium, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, Pasteurae Multocida.

Anaerobic type: Baceroides including B. Fragilis.

Pharmacokinetics

absorption

Amoxicillin and clavulanic acid are easily absorbed by oral. Maximum concentration in serum after 1-2 hours. The absorption of the drug is not affected by food and it is best to drink right before the meal. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%.

Distribution

both amoxicillin and clavulanic acid are distributed into the lungs, pleural fluid and peritoneal fluid, passing through the placenta. Amoxicillin is excreted in milk, there is no data that shows Clavulanic acid in the milk of mothers who are nursing.

Metabolism

Amoxicillin is metabolized very little in the body into a corresponding penicilloic acid. Clavulanic acid is partially metabolized into low molecular weight metabolites.

Elimination

Amoxicillin's waste time in serum is 1-2 hours and of Clavulanic Acid is about 1 hour. 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking Nuggets of Klamentin 500/62.5 DHG Pharma for respiratory infections (24 packs)

How to use

Mixed medicine with just enough water (about 5 - 10 ml of water for 1 pack), stir before drinking.

Take medicine right before meals to minimize the phenomenon of non -tolerated drugs in the stomach - intestines.

Dosage

Dosage is calculated by amoxicillin.

Adults:

Mild infections to medium:

1000/125 mg (2 packs) x 2 times/day.

1000/125mg (2 packs) x 3 times/day.

The treatment time lasts from 5 to 10 days. Treatment must not exceed 14 days without examination.

Children from 3 months of age:

otitis media , sinusitis, respiratory infections, severe bacterial infections:

45mg/kg body weight/day, divided into 2 times.

25mg/kg body weight/day, divided into 2 times.

Take adult dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? However, the acute reactions occur depending on the hypersensitivity of each individual.

The risk of hyperkalemia when taking the dose is very high because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Klamentin 500/62.5, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

digestive: diarrhea , vomiting, nausea.

Uncommon, 1/1000

Skin: itching, erythema, rash.

Blood: Nothing hypernagus.

Liver: hepatitis, jaundice.

Rare, 1/10,000

Systemic: Anaphylaxis, Stevens syndrome - Johnson.

Blood: thrombocytopenia, leukopenia, anemia hemolysis.

digestive: fake colitis.

kidney: interstitial nephritis .

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Klamentin 500/62.5 contraindications in the following cases:

Hypersensitivity to penicilin and cephalosporin.

Severe liver failure.

Be cautious when using

should adjust the dose in patients with renal failure.

Prolonged treatment can cause superinfection.

The ability to drive and operate machinery

rarely affects the ability to drive and operate machinery.

Pregnancy

There is no evidence of harmful effects for the fetus, but during pregnancy should only be used when really necessary.

Breastfeeding period

should be cautious when taking the drug during breastfeeding.

Drug interaction

Probenecid reduces the secretion of amoxicillin in the renal tubules, thus increasing the concentration of amoxicillin in the blood.

The drug can cause prolonged bleeding time and coagulation.

The drug can reduce the impact of oral contraceptives.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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