Nuggets of Livact Granules Ajinomoto oral solution improve blood albumin reduction (84 packages)

Dosage form Box 84 package
Specifications L-iSoleucine, L-Leucine, L-Valine

Ingredient

Composition information	Content
L-ISOLEUCINE	952mg
L-leucine	1904mg
L-Valine	1144mg

Uses

Indications

Livact 84g/h drugs are indicated in the following cases: To improve the reduction of blood albumin for compensated cirrhosis patients with lower blood albumin content or equal to 3.5 g/dl despite adequate diet.

Be cautious when indicated

Livact 84g/h is indicated for use in patients with reduced blood albumin albumin, although the amount of absorption from a full diet or in patients with total calorie absorption and protein (amino acid) from a limited diet due to diabetes with complications or cerebral liver disease, in patients with loss of compensated cirrhosis with reduced blood albumin as indicated by the albumin concentration of 3.5 or liver brain disease.

Need to guide patients on diet in case of deficiency in a diet, although the patient is full of food confusion when there is no diabetes and hepatic brain disease. If the patient is deficient in the amount of absorption from the diet due to the growth of cerebral disease, a drug contains calories and protein (amino acids).

Do not specify

Do not use this medication for patients with cirrhosis progresses significantly because such patients can not respond to Livact therapy 84g/h:

Patients with severe coma in phase III or higher due to hepatitis.

Patients with total bilirubin level 3 mg/dl or higher.

Patients with liver function of protein synthesis are significantly reduced.

Pharmacology

Effective and impact

A dosage response study was conducted in patients with cirrhosis with reduced blood albumin to determine the advantage of clinical research. In this test, Livact 84g/h is used every day at a dose of 6 g, 12 g, 18 g and compares with placebo in a non -blind study. Observing a significant increase in plasma albumin levels in groups of 12 g and 18 g groups compared to the placebo group. There is also a significant increase in the blood fischer ratio between data before taking the drug and data at week 12 after taking the drug. The common symptoms are improved in groups of 12 g and 18 g compared to the other 2 groups.

Mechanism of action

Using Livact 84g/h in patients with unprocessed cirrhosis will promote the albumin biosynthesis in the liver through improving the imbalance of amino acids in the blood.

Dynamic pharmacokinetics

The concentration of plasma chain amino acids is measured in adults, healthy (n = 48) when taking single dose of livact 84g/h (the dose is 1 pack containing L - Isoleucine 952 mg, L - Leucine 1904 mg, and L - Valine 1144 mg) at hunger. The pharmacokinetic parameters (area under the AUC road, maximum cmax concentration, ....) The adjective of the concentration change compared to the background line is presented as the table below:

Ingredients

cmax (mcg/ml)

auc (mcg.

TMAX (hour)

t1/3 (now)

30,982 ± 5,872

43,126 ± 9,884

0.677 ± 0.178

0.787 ± 0.305

58,531 ± 10,587

103,088 ± 19,671

0.688 ± 0.175

1,428 ± 0.243

46,796 ± 8,332

92,495 ± 19,948

0.724 ± 0.173

1823 ± 0492

When livact 84g/h is used orally, each amino acid is absorbed through its transportation in the small intestine.

Distribution

The amino acids are quickly orally distributed and used in the same way as endogenous amino acids.

Tourization

Each amino acid is combined and can be used as a substrate for protein synthesis and biological activity. On the other hand, amino amino acids go into the tricarboxylic acid (TCA), new glucose or fatty acid biosynthesis in the form of energy. Nitrogen in amino acids decomposed into urea in the urea cycle.

Elimination

The carbon frame in each amino acid can be decomposed into CO2 and H2O. CO2 can be excreted through exhalation. Nitrogen can be excreted in urine in the form of urea or ammonia.

Before taking Nuggets of Livact Granules Ajinomoto oral solution improve blood albumin reduction (84 packages)

How to use

Livact 84 g/H uses oral.

Dosage

The oral adult dose is 1 pack, 3 times/day after meals or as prescribed by a doctor.

Caution for dosage

livact 84 g/h includes single -chain amino acids and does not contain all amino acids needed for protein synthesis. Therefore, patients who are using Livact 84 g/h must use the amount of protein (amino acid) and the necessary calories (the amount of daily absorption protein is 40 g or more and the amount of calories absorbed daily is 1000 kcal or more) in a diet according to the patient's condition.

If the patient is restricting protein collection, especially the need for kidneys in case the patient may not respond to Livact therapy 84 g/h and moreover the long -term use of this product leads to severe nutritional condition of the body, unless the minimum demand for protein and calories is guaranteed.

If the urea nitrogen (bun) or ammonia abnormal blood ammonia after using livact 84 g/h, must be careful because this may be due to overdose. Be careful for long -term overdose because it can worsen the body's nutritional condition.

If there is no improvement in reducing blood albumin for 2 months or longer when using livact 84 g/h, it is advisable to apply appropriate measures such as replacement by other therapy.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Livact 84 g/h, you may experience unwanted effects (ADR).

Of the 420 cases studied before the approved drug, 40 side effects were reported in 27 cases (6.4%). Common side effects have been reported at the time of approved drugs including bloating (9 side effects, 2.1%), diarrhea (5 side effects, 1.2%) and constipation (4 side effects, 1.0%). (At the time of approved).

Of the 2,877 cases surveyed during after -sales monitoring, 267 side effects were reported in 178 cases (6,24). Common side effects have been reported including hyper ammonia (23 side effects, 0.84), nausea (15 side effects, 0.5%), diarrhea (14 side effects, 0.5%), hyperemia urea (bun) (14 side effects, 0.53%) and abdominal pain (12 side effects, 0.4%). (Data from re -test results).

Of the 334 cases in after -sales clinical studies (including long -term studies), 63 side effects have been reported in 41 cases (12.3%). Common side effects include bloating (13 side effects, 3.9%), constipation (9 side effects, 2.7%), diarrhea (5 side effects, 1.5%), itching (4 side effects, 1.2%), nausea (3 side effects, 0.9%) and vomiting (3 side effects, 0.9%). (Data from re -test results).

0.1 - 5%

Unknown ratio

abdominal distention, trafficking, diarrhea, constipation, abdominal discomfort, abdominal pain, vomiting, appetite, heartburn ...

thirsty, belching

Hypermath of blood urea (bun), serum creatinine, ...

hyper ammonia, ..

Increase AST (GOT) serum, increase Alt (GPT) acupuncture points, increase total bilirubin, ....

rash, itching, ...

uncomfortable, edema (face, lower limb), ...

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Livact 84 g/h contraindicated in the following cases:

Patients with abnormalities of congenital amino acid metabolism (the use of this drug can cause convulsions or respiratory disorders in patients with urinary diseases).

Patients with allergies to any ingredients of the drug.

Caution when using

used in the elderly

Livact 84 g/h should be used for kidneys for elderly patients because these patients often reduce physiological function and metabolic disorders such as blood ammonia can be easier to develop while treatment with Livact 84 g/h.

Used during pregnancy, childbirth or lactation

The safety of livact 84 g/h in pregnant women and nursing mothers has not been determined. Therefore, this product should not be used in pregnant women, women suspect pregnancy and nursing mothers unless the estimated benefits are higher than possible.

used in pediatrics

The safety of livact 84 g/h in children has not been determined (without clinical experience).

The ability to drive and operate machinery

In the case of using Livact 84 g/h, there is no case that has been reported on the ability to drive or operate machinery may be affected.

Pregnancy

The safety of livact 84 g/h in pregnant women has not been determined. Therefore, this product should not be used in pregnant women, women suspected that they are pregnant unless the estimated benefits are higher than possible.

The period of breastfeeding

The safety of livact 84 g/h in breastfeeding women has not been determined. Therefore, this product should not be used in breastfeeding women unless the estimated benefits are higher than possible.

Drug interaction

There is no report showing interaction with other drugs.

Storage

Store at temperatures below 30 ° C.

Other drugs

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