Nugn Novafex 100mg/5ml Mekophar Treatment of respiratory infections (60ml)

Dosage form Box x 60ml
Specifications Cefixim

Ingredient

Thành phần cho 5ml

Composition information	Content
Cefixim	100mg

Uses

indications

Novafex drugs are indicated in the following cases:

Upper and lower respiratory respiratory tract such as sore throat and tonsils, pneumonia, acute and chronic bronchitis, otitis media. 3rd generation cephalosporin, orally used. The drug has a bactericidal effect.

Cefixime's bactericidal mechanism

Attached to target proteins (penicillin -mounted proteins) inhibit mucopeptide synthesis in bacterial cell walls.

Cefixime works on most Gram -negative bacteria and some gram -positive bacteria.

Gram -positive bacteria: Streptococcus Pneumonia, Streptococcus Pyogenes.

Gram -negative bacteria: Haemophilus influenzae (secretion or no beta - lactamase), Moraxella Catatrhalis (most beta - lactamase secretion), Escherichia coli, Proteus Mirabilis, Neisseria Gonorrhoeae (period or non -penicillinase secretion).Bacterial resistance mechanism of bacteria is to reduce Cefixime's affinity for target protein or reduce the permeability of bacterial cell membranes for drugs.

Cefixime is highly sustainable with the hydrolysis of beta - lactamase encoded by the gene located on plasmid and chromosom. Sustainability with beta - lactamase of Cefixime is higher than Cefaclor, Cefoxitin, Cefuroxime, Cephalexin, Cephradin.

Dynamic pharmacokinetics

After taking a single dose of Cefixime, only 30-50% of the dose is absorbed through the gastrointestinal tract, regardless of drinking before or after the meal, although the absorption rate may be reduced when drinking with meals. Half life in plasma is usually about 3 to 4 hours. About 65% Cefixime in the blood is attached to plasma proteins.

About 20% of oral doses are eliminated in the form of unchanged urine within 24 hours. Up to 60% of oral dose without kidney.

Before taking Nugn Novafex 100mg/5ml Mekophar Treatment of respiratory infections (60ml)

How to use

Take oral use. Do not use hot water or warm water. Shake well before use.

Dosage

Usual dose

Adults and children> 12 years old (or weight> 50 kg): Take 400 mg/day, can be used once or divided 2 times apart 12 hours.

Children 6 months - 12 years: Take 8 mg/kg/day, take 1 single dose or divide 2 times, each time 12 hours apart.

1 -year -old children -

5 -year -old children -

Children 10 years old -

Dosage for patients with renal failure

Creatinine clearance

Creatinine clearance 21 - 60 ml/minute: Use Cefixime 300 mg/day.

Creatinine clearance> 60 ml/minute: No dose adjustment.

Because Cefixime does not lose through hemolysis, people with dialysis and peritoneal filtering do not need to add the dosage of cefixime.

normal treatment time

Urinary tract infections and upper respiratory tract: from 5 - 10 days.

Lower respiratory infections and otitis media: from 10 - 14 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Because there is no specific treatment, it is mainly symptomatic treatment.

When there is an overdose symptom, stop the drug immediately and handle as follows: gastrointestinal lavage, anti -convulsions may be used if there is clinical indications.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Novafex, you may experience unwanted effects (ADR).

Common

Digestive: diarrhea, abdominal pain, vomiting, nausea, flatulence, not delicious, dry mouth. Gastrointestinal disorders usually occur in the first 1-2 days of treatment and respond to symptomatic medications, rarely stop the drug.

Nervous system: headache, dizziness, restlessness, insomnia, fatigue.

Hypersensitivity: Red rash, urticaria, drug fever.

Less

Digestive: severe diarrhea caused by Clostridium difficile and fake colitis.

Systemic: Anaphylaxis, angioedema, Stevens - Johnson syndrome, diverse roses, poisoned epidermal necrosis.

Hematology: reduced platelets, leukocytes, white blood cells; Reduce hemoglobin and hematocrit concentrations.

liver: hepatitis and jaundice; Temporarily increased AST, ALT, alkaline phosphatase, bilirubin and LDH. kidney: Acute renal failure, hyperlemen nitrogen non -protein and temporary plasma creatinine levels.

Other: Vaginal cantiditis and infection.

Rare

Hematology: Prothrombin time.

Body: convulsions.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Novafex drugs contraindicated in the following cases:

Patients with a history of hypersensitivity to Cefixime or other antibiotics of Cephalosporin group, who has a history of anaphylaxis due to penicillin.

Caution when using

people with a history of gastrointestinal diseases and colitis, especially when used for prolonged use, because there may be excessive risk of developing anti -drug bacteria, especially Clostridium difficile in the intestine as severe diarrhea, need to stop the drug and treat with other antibiotics (Metronidazole, Vancomycin, etc. In addition, diarrhea for 1-2 days is mainly due to the drug, if mild does not need to stop the drug. Cefixime also changes the bacteria in the intestine.

Dosage and/or the number of drugs need to be reduced in people with renal impairment, including patients who are dialysis in the kidneys due to plasma cefixime levels in patients with higher renal impairment and longer than those with normal kidney function.

Children under 6 months old.

For the elderly: In general, there is no need to adjust the dose, unless there is impaired renal function (creatinine clearance

The ability to drive and operate machinery

There is no study of Cefixime effect on the ability to drive and operate the machine. There is no evidence to state the influence of cefixime on these possibilities.

Pregnancy

only use drugs when really necessary.

Breastfeeding period

Be cautious when using the drug, may suspend breastfeeding during the medication period.

Drug interaction

Probenecid, Nifedipine increases the bioavailability of cefixime manifesting by increasing the peak and AUC concentration.

anticoagulants like warfarin when used with cefixime increases prothrombin time, with or without bleeding.

Carbamazepine taken with cefixime increases carbamazepine levels in plasma.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

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