Nuradre 400 hard capsules for local epilepsy treatment (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	400mg

Uses

Indications

Nuradre 400 drug are indicated in the following cases:

Singles of local epilepsy therapy whether or not with secondary allearies in adults and children over 12 years old.

Treatment of local epilepsy support or not accompanied by secondary whole attacks in children from 3 years old.

Treatment of pain caused by peripheral neuralgia (after shingles , diabetes ...) for patients aged 18 and older. Aminobutyric (GABA). But it is not a homogeneous substance or the opposite of the GABA receptor. The mechanism of action is unknown, the printing - vitro studies using gabapentin marked with radioactive material have shown a new peptid mounting location in mouse brain tissue including new cerebral cortex and hate legs, this feature may be related to the anti -seizure effect of the drug.

gabapentin reduces the release of neurotransmitters with monoamine structure on in vitro. In animals, gabapentin enters the brain easily and preventing seizures due to electric shock, chemical agents including GABA synthesis inhibitors and epilepsy on epilepsy models.

pharmacokinetics

gabapentin is absorbed through the gastrointestinal tract under a saturated mechanism, which means that the absorption is not proportional to the dose that to a certain level of saturation, the absorption decreases. Gabapentin's peak concentration is achieved after drinking for 2 hours and reaches a stable condition in 1-2 days.

gabapentin is not metabolized, most of the dose is excreted intact through the urine, the rest is excreted through the stool. Gabapentin is widely distributed throughout the body but very little plasma protein binding. Selling time is about 5 - 7 hours. The drug is excreted in breast milk. The elimination of drugs is reduced in elderly patients, patients with renal impairment and can be eliminated through dialysis.

Before taking Nuradre 400 hard capsules for local epilepsy treatment (5 blisters x 10 tablets)

How to use

Take oral use.

Can take medicine during or outside meals.

Dosage

Anti -epilepsy in adults and children over 12 years old

Effective dose is from 900mg - 1800mg per day. Can start with capsules 300mg or 400mg, 3 times on the first day or standard as follows:

300mg or 400mg, 1 time of the first day.

300mg or 400mg, 2 times of the 2nd day.

300mg or 400mg, 3 times of the 3rd day.

Then increase the dose of hiccups to achieve the usual treatment effect of 900 - 1800mg, maximum of no more than 2400mg/day divided into 3 drinks, the distance of each time not exceeding 12 hours. When using high doses can be divided into 4 drinks. There are a few cases of 3600mg/day doses that are also used for a relatively short time and also feel good tolerance.

For people with kidney failure

Need to adjust the dose for patients with renal failure depending on the following creatinine clearance as follows:

Creatinin clearance

The total daily dose of the day 49ml/minute 300 - 600mg, divided 3 times

for dialysis people

The loading dose is 300 - 400mg and then reduced to 200 - 300mg after every 4 hours of fertilization.

Children from 6 to 12 years old

The first day: 10mg/kg/day, divided 3 times.

Monday: 20mg/kg/day, divided 3 times.

Tuesday: 25mg - 35mg/day, divided 3 times.

Maintenance dose is 900mg/day for children weighing from 26kg - 36kg and 1200mg/day with children weighing from 37kg - 50kg. The dosage of the day is divided into 3 drinks.

Children from 3 to 6 years old

The first dose: 10mg - 15mg/kg/day, divided 3 times. Then increase the dose in 3 days to get a dose of 25 - 30mg/kg/day for children 3-4 years or 25 - 30mg/day for children 5 years old or more. The total dose of the day is divided into 3 drinks.

There is no evaluation of gabapentin for children under 12 years of age.

Treatment of neurological pain in patients 18 years of age: The dose must not exceed 1800mg/day, divided into 3 times, the standard starting dose is similar to the dose of epilepsy in adults. Then increase the dose to up to 1800mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose include: dizziness, double look, tongue, sleepy, sleeping and mild diarrhea. Supporting treatment can help completely recover. Although dialysis can remove gabapentin from the body, experience is often not needed to use this method and only used for cases of patients with severe renal failure.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using nuradre 400 , you may experience unwanted effects (ADR).

Fatigue, headache , dizziness, sleep, trembling, shaking eyeballs.

Abdominal pain, nausea, vomiting, diarrhea .

Muscle pain, weight gain.

Failure, confusion, depression .

Reduce vision, look at a couple.

cough, sore throat, rhinitis.

Skin, acne.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Nuradre 400 contraindicated in the following cases:

Patients with hypersensitivity to Gabapentin or any ingredients of the drug.

Precautions when used

Monitoring of Gabapentin concentrations in plasma to optimize chemotherapy is not necessary. Gabapentin can be used in combination with other anti -epileptic drugs without caring for the change of gabapentin concentration or the concentration of other anti -epileptic drugs in plasma.

All dose, stop or replacement with other anti -convulsions must be done slowly for at least 1 week to avoid the occurrence of continuous seizures for patients due to sudden suspension.

In general, Gabapentin is not effective in the treatment of seizures.

Each day should take the drug at the same time, to maintain the concentration of medication in the blood stable.

Use cautious for people with a history of mental disorders, people kidney failure , blood decenters, train operators or machinery.

The drug can cause false positive when testing proteinuria.

The ability to drive and operate machinery

Do not use drugs for drivers or operating machinery.

Pregnancy

only used for pregnant women when the treatment benefits bring superior risks on the fetus.

Breastfeeding period

The drug goes into breast milk, the influence on breastfed babies is not well known. Therefore, the drug should only be used for women during breastfeeding when the treatment benefits are clearer than the risks.

Drug interaction

There is no interaction between Gabapentin and Phenobarbital, Phenytoin, Valproic Acid or Carbamazepin.

Use Gabapentin at the same time with antacids containing aluminum salt and magnesium salt that reduces the bioavailability of gabapentin about 20%, so it is advisable to use the drug apart at least 2 hours.

The retention of gabapentin through the kidney is not affected by probenecid.

cimetidine reduces gabapentin's clearance but this reduction has no clinical significance.

Storage

Temperature does not exceed 30 ° C.

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