Ocedio 80/12.5 VCP treatment for high blood pressure (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Valsartan, hydrochlorothiazide

Ingredient

Composition information	Content
Valsartan	80mg
Hydrochlorothiazide	12.5mg

Uses

indications

Ocedio drugs are indicated in the following cases:

Treatment of hypertension.

pharmacokinetics

No data.

Before taking Ocedio 80/12.5 VCP treatment for high blood pressure (5 blisters x 10 tablets)

How to use

oral tablets. Mix and disperse drugs in 20 30ml of water, drink after mixing. Dosage

recommended dose for adults: 1VN/day.

In case of necessity can use 2 capsules/day.

Effective achieved within 2 to 4 weeks of treatment.

Patients with renal failure

lightweight and medium (glomerular filtration coefficient GFR ≥ 30 ml/minute): No dose adjustment.

lightweight and moderate due to non -bile -free causes: No dose adjustment.

Elderly: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

symptoms:

Although there is no data on the use of overdose, the main symptoms that may occur are obvious hypotension.

Overdose Valsartan: can cause hypotension, which can lead to circulation and shock.

When experiencing signs and overdose symptoms, it is necessary to stop the drug immediately and go to the nearest medical facility.

Treatment measures depend on medication time and the severity of symptoms. If newly taken, it may cause efforts. Stabilizing the circulatory status is important. If hypotension occurs, the patient should be placed in a lying position and intravenously physiological saline.

Valsartan cannot be removed by dialysis because it is strongly connected to plasma, while hydrochlorothiazid can be removed by a cup.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Ocedio, you may experience unwanted effects (ADR) such as:

Combined Valsartan and Hydrochlorothiazide

Uncommon, 1/1000

Disorders of metabolism and nutrition: dehydration. tired.

Very rare ADR Nervous system disorders: Dizziness.

Nervous system disorders: fainting.

respiratory disorders, chest: pulmonary edema. Calculate.

Valsartan

Uncommon, 1/1000

Ear and maze disorders: Dizziness.

Blood and lymphatic disorders: Hemoglobin decrease, reduced red blood cell capacity, thrombocytopenia. liver.

can cause excessive potassium loss. This effect depends on the dose and can be reduced when low doses (12.5 mg/day), the best dose for hypertension treatment, while minimizing harmful reactions.

Common, ADR> 1/100:

Body: Fatigue, dizziness, dizziness, headache.

circulatory: lower blood pressure, arrhythmia. Blood.

Rare, ADR

Systemic body: Anaphylaxis reaction, fever. Difficulty breathing, pneumonia, pulmonary edema (anaphylactic reaction). Hypotension may occur when used with alcohol, anesthetic and sedative.

Instructions on how to handle ADR:

Dehydration and electrolytes can cause hypotension, alkaline metabolism, hypokalemia, sodium blood. It is necessary to check the electrolytes and compensate for the amount of water and electrolytes. People with coronary artery disease, ischemia heart disease are very sensitive to potassium loss and risk of arrhythmia. Serum potassium concentration below 30me/liter is high risk.

These patients should be carefully checked for electrolyte balance and need potassium compensation, when treated with any diuretics. Using low doses of diuretics is important to limit this harm.

Patients who are treating digitalis are at risk of digitalis poisoning when potassium in the blood decreases. Potassium addition needs to use diuretics.

Patients who are treating quinidine are at risk of arrhythmia when reduced potassium.

It is necessary to check the electrolyte and add potassium. It is also necessary to be so cautious for patients who are being treated with any drugs that affect the diarrhea, such as phenothiazin and three -round antidepressants.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ocedio drugs are contraindicated in the following cases:

Too hypersensitivity to any ingredients of the drug. Symptoms of hyperuricemia.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Renin-Anotesin-Aldosteron (RAAS):

As a consequence of the inhibition of the Renin-Anotesin-Aldosteron system, there was a report on increased risk of hypotension, hyperkalemia and reduced kidney function (including acute renal failure).

Therefore, it is not recommended to use RAAS dual blockbounds through the combination of enzyme inhibitors, Angiotensin II or Aliskiren receptor blockers.

Patients with severe chronic heart failure or other diseases with the Renin-Anotensin-Andosteron system stimulation:

On patients with vascular tone and renal function depend largely on the activity of the renin-angiotensin-aldosterone system (for example, patients with severe congestive heart failure or basic kidney disease, including kidney artery stenosis), the treatment with other drugs affects the renin-angiotensin-aldosteron system related to acute hypotension, increased blood urban, rarely causes acute impairment.

Acute glaucoma:

Hydrochlorothiazd is involved in an incredible reaction that creates a rapid myopia and acute closed glaucoma.

Electrolyte balance:

Valsartan: It is not recommended to use simultaneously with potassium supplements, potassium diuretic, salt replacement salt containing potassium or other substances that increase potassium (heparin, ...). Potassium monitoring should be done when appropriate.

hydrochlorothiazid: Hypotension is covered in the case of thiazid diuretics. It is recommended to regularly check the concentration of potassium in serum. Treatment of thiazid diuretics is associated with sodium hypoglycemia and chlorine. Thiazid increases the secretion of magnesium through the urine and can lead to lower blood magmesi.

Patients with salt and/or volume loss:

Cases of salt loss and/or severe volume loss due to high doses of diuretics, symptoms of lower clothes may be encountered in a special shift after starting treatment.

Must compensate for enough salt and fluid before treatment.

Kidney artery stenosis:

Patients with one or both sides or narrowed kidney stenosis on patients have only one kidney, the safety of the drug's use has not been determined.

kidney failure:

No dose adjustments in patients with renal failure (Creatinin clearance coefficient> 30 ml/min).

Hepatic failure:

No need to adjust the dose to patients with mild and moderate liver failure due to non -bile -free bile causes. However, the drug must be used carefully. Hepatic pathology does not significantly change pharmacokinetics of hydrochlorothiazid.

Lupus system system:

There have been reports on thiazid diuretics that seriously or activated systemic lupus erythematosus.

Other metabolic disorders

thiazid diuretics may be changing the ability to tolerate glucose and increase the concentration of cholestrol triglycerides, and uric acid in serum.

All patients using thiazids (including hydrochlorothiazid) must be monitored periodically in the bar and urine, especially patients using corticosteroids, acthers or digitalisquinidin (risk of vibration torsion).

Hypotension effect of hydroclothiazid increases in patients after sympathetic nerve removal.

Lactose-like drugs should be braided with rare genetic disorders in galactose tolerance, lactase lactase deficiency or glucose-galactise absorption disorders should not be used.

The effect of the drug on the ability to drive and operate machinery

There is no complete research data on this object, sometimes may have tired dizziness, so be careful to use the drug when driving and operating machinery.

Use drugs for women during pregnancy and lactation

Contraindications.

Drug interaction

hydrochlorothiazide:

When used with the following drugs can interact with thiazid diuretics:

Alcohol, barbiturate or addictive sleeping pills: Increasing potential of antihypertensive potential. Or increase the potential of hypotension. Hydrochlorothiazid's potassium effect may increase when using potassium diuretics, corticosteroids, laxatives, acthers, amphotericin, carbenoxolon, penicillin G, salicylic acid and derivatives. If these products are prescribed with this drug, plasma potassium concentration should be monitored. Diuretics, because of reducing lithium removal and increases the toxicity of this substance.

Used in combination with nonsteroidal anti -inflammatory drugs (such as the derivative of Salicylic Acid, Indomethacin) can reduce the diuretic and anti -blood pressure effect of the thiazid ingredient in the drug. Reducing blood flow can lead to acute renal failure. Calcium is in danger of increasing the calcium concentration in serum. The intestines and stomach contractions are significantly hungry. Patients should be compensated before use. Nhan. May be enhanced by using drugs such as antidepressants, anti -psychotic drugs, anti -epileptic drugs, ... Note when taking long -term drugs.

valsartan:

When used with the following drugs can interact:

Used in conjunction with potassium diuretics (such as Spironolacton, Triamteren, Amilorid), potassium supplements or salt-containing salt-containing salt drugs that can lead to an increase in serum potassium level and in patients with heart failure may increase serum creatinine levels. The inhibition of the renin-aniotesin-aldosteron system has reported an increase in the risk of hypotension, hyperkalemia and reduced kidney function (including acute renal failure). Therefore, it is not recommended to use the RAAS dual clutches through the combination of enzyme inhibitors, Angiotensin II or Aliskiren receptor blockers.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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