Ofbexim 200 USP tablets treat urinary tract infections (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Cefixim

Ingredient

Composition information	Content
Cefixim	200mg

Uses

indications

ofbexim 200 USP 3x10 drugs are indicated in the following cases:

Inhabited urinary tract infections due to sensitive strains of E.coli or Proteus Mirabilis and some cases of non-complicated urinary tract infections due to other gram-noodles such as Citrobacter spp, Entracterter spp., Klebsiella spp., Proteus spp.

Some cases of nephritis - pyelonephritis and urinary tract infections have complications caused by sensitive enerobacteriaceae, but the treatment results are worse than in case of unemployed urinary tract infections.

Acute otitis media caused by Haemophilus Influenzae (including beta-lactamase strains), Moraxella Catatrhalis (including beta-lactamase strains), Streptococcus pyogenes.

Sore throat and tonsils due to streptococcus pyogenes.

Acute and chronic bronchitis caused by Streptococcus Pneumoniae or Haemophilus Influenzae or Moraxella Catarrhalis.

Mild to moderate pneumonia, including the pneumonia sufficient in the community.

The drug is also used to treat gonorrhea without complications caused by Neisseria gonorrhoeae (including beta-lactamase strains); typhoid disease caused by salmonellatyphi (including multi -resistant strains); Sensitive shigella dysentery (including ampicillin resistant strains).

Pharmacology

cefixim inhibits the synthesis of bacterial cell walls by linking to one or more penicillin bonding proteins (PBP); Therefore, inhibiting the final transpeptide step of peptidoglycan synthesis in bacterial cell walls, thus inhibits biosynthesis of cell walls.

Finally, bacteria are solved due to the continuous activity of self -resolving enzymes into cells (Autolysin and Murein Hydrolase) while the process of assembling cells into cells is arrested.

Dynamic pharmacokinetics

absorption: absorption from 40% to 50%.

Distribution: widely throughout the body and achieving treatment concentrations in most tissues and fluid fluids, including fluid, pericardium, pleura, and peritoneal; bile, sputum and urine; Bones, heart muscle, gallbladder, leather and soft tissue. Protein bond: 65%

Elimination: Excretion in urine 50% of the absorption dose in the form of active drugs, through feces (10%). Selling time: Normal kidney function: 3 to 4 hours; Average decline (CrCl 20 to 40 ml / minute): 6.4 hours; Renal failure: up to 11.5 hours.

Before taking Ofbexim 200 USP tablets treat urinary tract infections (3 blisters x 10 tablets)

How to use

Ofbexim 200 drugs are taken orally. Should take medicine after eating.

Dosage

Adults: Common dose in adults 200 mg - 400 mg/day can be used once or divided into 2 times 12 hours apart.

To treat uncomplicated gonorrhea due to Neisseria Gonorrhoeae (including beta-lactamase strains): Taking a dose of 400 mg (a single dose, more combined with an antibiotic effectively for Chlamydia due to being infected at the same time).

For adults with spreading gonorrhea, the beginning of treatment with ceftriaxon, cefotaxim, ceftizoxim or spectinomycin and after the disease starts improving, continue to be added as the start within 24-48 hours, then change to oral cefixim, dose of 400 mg/time, drink 2 times/day and for a minimum of 1 week.

When kidney failure needs to adjust the dose accordingly.

Children:

Children over 12 years old or weighing over 50 kg: taking doses like adults.

To treat uncomplicated gonorrhea due to Neisseria gonorrhoeae for 8 -year -old children or older with weight equal to or over 45 kg: taking a dose of 400 mg (a single dose), coordinating with an antibiotic effectively for Chlamydia due to being likely to be infected at the same time.

Dosage for kidney failure: No dose adjustment for patients with creatinine clearance> 60 ml/min. For patients with creatinine clearance

Adults have creatinine clearance 21 - 60 ml/minute cefixim dose of 300 mg/day, if creatinine clearance

Treatment time: Depending on the type of infection, it should be extended for 48-72 hours after the symptoms of infections have gone. The usual treatment time for uncomplicated urinary tract infections and upper respiratory tract infections is from 5-10 days (if due to streptococcus group A, Beta hemolysis must be treated at least 10 days to prevent heart rheumatism or glomerulonephritis), lower respiratory infections and middle ear infections: 10-14 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ofbexim 200, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, abdominal pain, nausea, indigestion, flatulence, loose stools

Uncommon, 1/1000

Systemic: Anaphylaxis, anaphylaxis, angioedema, dizziness, drug fever, face edema, fever, convulsions, Stevens-Johnson syndrome.

digestive: vomiting, fake colitis. skin: Poisoned epidermal necrosis, urticaria, diverse erythema, candidiasis. Blood: Nothing hypernagus, leukopenia, neutropenia, thrombocytopenia, long prothrombin time. liver: increased serum transaminase, hepatitis, hyperlirubin blood; jaundice. kidney: Acute renal failure.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

ofbexim 200 drugs contraindicated in the following cases:

Patients with a history of hypersensitivity to Cefixim or with other cephalosporin antibiotics.

People with a history of anaphylaxis due to penicillin or allergies to other ingredients of drug products.

Caution when using

Careful when using Cefixim in people with a history of gastrointestinal diseases and colitis, especially when used for prolonged use.

Dosage or number of drugs should be reduced in people with kidney failure.

For children under 6 months of age, so far there is no data on safety and effectiveness.

For the elderly: no dose adjustment, unless there is impaired renal function (creatinine clearance

Recommended patients with rare genetic disorders in galactose tolerance, lactate lactate deficiency. Or Glucose-Galactose absorption disorders should not use this drug.

The drug contains saccharose can be harmful that if used for two weeks or more. Aspartam can be harmful to people with phenylpyruvic acid in the urine.

The ability to drive and operate machinery

Because the drug can cause dizziness so be careful when using the drug for the driver and operating machinery.

Pregnancy

There has been no complete research on pregnant women, when studying in animals, there is no impact on the fetus. Therefore, only use the drug when really necessary. Risk of pregnancy according to FDA: level b.

The period of breastfeeding

Currently, it has not yet been confirmed that Cefixim is distributed into milk or not. Therefore, it is advisable to use medication for women who are cautious, can temporarily suspend breastfeeding during medication.

Drug interaction

Probenecid increases the peak and AUC concentration of Cefixim, reducing the clearance of the kidneys and the distribution of the drug.

anticoagulants like warfarin when used with cefixim increase prothrombin time and can enhance anticoagulant effects.

Storage

A dry place, temperatures below 300C.

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