Oflovi Ophthalmic Ointment Santen Eye Santen treat lash inflammation, pocket, ferades (3.5g)

Dosage form Tube x 3.5g
Specifications Ofloxacin

Ingredient

Composition information	Content
Ofloxacin	0.3%

Uses

indicators

Oflided 3.5g eye ointment is indicated for treatment in diseases with bacterial infections caused by sensitive bacterial strains of Ofloxacin: lash inflammation, pocket inflammation, ferade (conjunctivitis, eyelashitis, corneal inflammation (including corneal ulcer), and used as antibiotic antibiotic for eye and postoperative surgery.

Bacteria are specified:

The following infections are caused by sensitive strains of bacteria with ofloxacin: Staphylococcus sp., Streptococcus sp., Streptococcus pneumoniae, Enterococcus sp., Micrococcus sp., Moraxella sp., Corynebacterium sp. Morganella Morganii, Providencia sp., Haemophilus influenzae, Haemophilus aegyptius [Koch - Weeks], Pseudomonas sp., Pseudomonas Aeruginosa, Burksharingia Cepacia, Stenotrophomonas (Xanthomonas) sp., Propionibacterium acnes, and Chlamydia trachomatis.

Pharmacokology

Mechanism of action

Ofloxacin is thought to be a special bacterial DNA inhibitors through inhibiting the activity of DNA Gyrase (Topoisomerase II) and Topoisomerase IV. The drug has a bactericidal effect and the observation of bacteria that are observed in minimum inhibition concentrations (MICS). Ofloxacin has also been recorded to destroy the basic part of Chlamydia Trachomatis in its development cycle.

Antibacterial activity

Ofloxacin has strong antibacterial activity, broad spectrum, against eye -causing bacteria, including gram -positive bacteria such as Staphylococcus sp., Streptococcus sp. (including s.pneumoniae), micrococcus sp., corynebacterium sp., ...), gram -negative bacteria like pseudomonas sp. (including P. Aeruginosa), Haemophilus sp., Moraxella sp., Serratia sp., Klebsiella sp., Proteus sp., acinetobacter sp.

Ofloxacin also has the activity against chlamydia species, including chlamydia trachomatis. It is also found that Chlamydia species are difficult to resist with Ofloxacin.

Dynamic pharmacokinetics

blood concentration

The appropriate amount of Oflidoval eye ointment is pasions 16 times every 30 minutes in healthy mature volunteers. 30 minutes after the last testing, the concentration ofloxacin in the blood is 0.009 PG/ml or less.

Before taking Oflovi Ophthalmic Ointment Santen Eye Santen treat lash inflammation, pocket, ferades (3.5g)

How to use

eye medicine.

Dosage

Normally, an appropriate amount (about 1 cm of Oflidoval ointment) into the lower eyelid, 3 times a day. The dosage can be adjusted according to the patient's symptoms through the frequency of use and leave at least 30 minutes the distance between the use.

In a clinical study, the 0.3% Ofloxacin eye ointment (1 cm, 16 times, 30 minutes apart between the times) was repeated on both eyes in healthy adult male volunteers (n = 6). Two objects of ointment shows hemorrhage and swelling, but these symptoms are mild and see nothing abnormal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Without information.

What to do when forgetting a dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose and continue the schedule of Oflidoval. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects have been reported in 14 out of 2,360 patients (0.59%) in clinical trials and after -sales monitoring in Japan. The unwanted effect includes: eyelid itching in 3 patients (0.13%), swelling of the eyelids in 3 patients (0.13%), lash inflammation in 2 patients (0.08%), conjunctival congestion in 2 patients (0.08%), eye pain in 2 patients (0.08%) and red eyelids in 2 patients (0.08%) ... (at the end of the re -examination period).

Unwanted effects of clinical significance

shock, anaphylactic reaction (unknown incidence)

Patients should be carefully monitored by shock and response reactions that may occur. If there are any symptoms such as erythema, rash, shortness of breath, lower blood pressure, eyelid edema ..., must stop taking the drug and take appropriate treatment.

other unwanted effects

If there is any unwanted effect, it is advisable to apply appropriate measures such as stopping the drug.

hypersensitivity

ban, urticaria (unknown ratio).

itching (0.1 - 5%).

Red eyelid (red eyelid and eyelid edema), eyelid dermatitis (

Eyes

conjunctivitis (conjunctiva and conjunctiva ...), corneal disorders including spreading corneal infection (unknown ratio).

Warnings

Before using Oflidoval Eye Agreement, you need to read the instructions carefully and refer to the information below.

Contraindicated

Oflidoval eye ointment is contraindicated for the following cases:

Hypersensitivity to any ingredients of the drug, or with any Quinolon antibiotic.

Be cautious when used

In order to avoid the appearance of anti -drug bacteria, it is necessary to confirm the sensitivity of bacteria. In addition, treatment with this drug should be limited to the minimum time needed to kill infections.

Avoid prolonged use. The standard time to treat conjunctivitis caused by Chlamydia trachomatis with this drug is 8 weeks. Be careful when continuing to take this medication for a longer time.

Read the instructions carefully before use. If you need more information, you need to consult your doctor.

This drug is only used by a doctor.

Notify the doctor with unwanted effects when using the drug.

To be out of reach of children.

The ability to drive and operate machinery

unknown.

Pregnancy and breastfeeding period

The safety of drugs in pregnant and lactating women has not been set. Therefore, it is not recommended to use drugs for these subjects.

Drug interaction

No data.

Storage

Store in a cool dry place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

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