Ofloxacin 200mg Imexpharm treat infection (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Ofloxacin

Ingredient

Composition information	Content
Ofloxacin	200mg

Uses

indications

ofloxacin 200 mg is indicated in the following cases:

Treatment of sensitive bacterial infections:

Bronchitis severe bacteria, pneumonia .

Chlamydia infections in the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, prostatitis, urinary tract infections.

Skin infections and soft tissue.

colitis due to bacterial infection.

Pharmacy

ofloxacin is an antibacterial drug of fluoroquinolon, with wide antibacterial spectrum including Enterobacteriaceae, Pseudomonas Aeruginosa, Haemophilus Influenzae, Neisseria spp, Staphylococcus, Streptoccus Pneumoniae Some other gram -positive bacteria.

It also works for Mycobacterium Laprae and even with mycobacterium tuberculosis and some mycobacterium spp. other.

Ofloxacin has bactericidal effects. Like other antibacterial quinolones, Ofloxacin inhibits DNA - Gyrase is an essential enzyme in the process of duplication, code transcription and DNA repair of bacteria.

Pharmacokinetics

absorption

Ofloxacin is absorbed quickly and well through the gastrointestinal tract. Oral bioavailability is about 100% and has a plasma peak concentration of 3-4 micrograms/ml, 1-2 hours after taking 1 dose of 400 mg. Absorption is slowed down when food is available but the absorption rate is not affected. Half life in plasma is 5 - 8 hours; In the case of renal failure, sometimes lasts 15 - 60 hours depending on the degree of renal failure, then the dose adjustment is needed.

Distribution

Ofloxacin is widely distributed into body fluids, including cerebrospinal fluids and well penetrated into tissues. About 25% of the plasma concentration in plasma is attached to plasma proteins. Drugs through the placenta and secretion through milk. There is a relatively high concentration in bile.

Metabolism

When using single dose, less than 10% ofloxacin is converted into desmethyl ofloxacin and ofloxacin n oxyd. Desmethyl ofloxacin has an average antibacterial effect.

Elimination

The kidney is the main site of Lainacin, the drug is filtered through the glomerular. 75 - 80% of the drug is excreted in urine in the form of non -metabolized urine; 4 - 8% of the drug excreted through feces. Only a small amount ofloxacin is discharged by hemolysis.

Before taking Ofloxacin 200mg Imexpharm treat infection (2 blisters x 10 tablets)

How to use

use orally.

Dosage

Adults

Bronchitis is seriously ill causable by bacterial or pneumonia: Take 400 mg 12 hours/1 time, for 10 days.

Chlamydia infection (in the cervix and the ureter): Take 300 mg, 12 hours/1 time, for 7 days.

Gonorrhea, uncomplicated: Take 400 mg, 1 single dose.

Prostatitis: Take 300 mg, 12 hours/1 time, for 6 weeks.

Skin and soft tissue infections: Take 400 mg, 12 hours/1 time, for 10 days.

Urinary tract infections:

Cystitis by E. Coli or K. Pneumoniae: Take 200 mg, 12 hours/1 time, for 3 days.

cystitis caused by other bacteria: taken 200 mg, 12 hours/1 time, 7 days.

Urinary tract infections have complications: Take 200 mg, 12 hours/1 time, for 10 days.

Adults of kidney function

Creatinine clearance> 50 ml/minute: The dose does not change, drink 12 hours/1 time.

Creatinine clearance 10 - 50 ml/minute: The dose does not change, drink 24 hours/1 time.

Creatinine clearance

Dosage children until 18 years old

Do not recommend use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

When experiencing symptoms due to overdose use, it is necessary to immediately visit medical facilities for examination.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ofloxacin 200 mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: nausea, vomiting, diarrhea, abdominal pain and digestive disorders .

Neurological: headache, dizziness, fatigue, tremor, insomnia, nightmares, visual disorders . skin: rash, itching, skin reaction too hypersensitivity.

Uncommon, 1/1000

Pain and irritation, sometimes accompanied by venous inflammation and thrombosis.

Rare, ADR

Neurological: hallucinations, psychotic reactions, depression, convulsions.

Skin: Vascular inflammation, Stevens syndrome - Johnson and skin toxic necrosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Ofloxacin 200 mg Contraindications in the following cases:

People with a history of hypersensitivity to ofloxacin other quinolones and/or other ingredients in preparations.

ofloxacin can cause degeneration of articular cartilage in the bearing joints on experimental animals, so do not use drugs for children under 15 years old, pregnant women and nursing women.

Be cautious when using

Caution for patients with epilepsy or a history of central neurological disorders.

The dose must be reduced for patients with renal failure.

Stop treatment if there are mental, nervous and hypersensitivity reactions (heavy rash).

The ability to drive and operate machinery

Caution if you experience the side effects of the drug such as headache, dizziness, fatigue, tremor, visual disorders, hallucinations.

pregnancy

ofloxacin through the placenta. It is also found that ofloxacin in amniotic fluid of more than half of pregnant mothers who use drugs. There are no works that have been monitored well and fully on people.

However, because ofloxacin causes joint diseases in young animals, ofloxacin should not be used during pregnancy.

The period of breastfeeding

ofloxacin has excreted breast milk with the same concentration as in plasma. Fluoroquinolon has been known to cause permanent damage to the cartilage of bearing joints and many other signs of disease in young animals. So if you cannot replace other antibiotics and still have to use ofloxacin, you should not breastfeed.

Drug interaction

Take oral ofloxacin with nonsteroidal anti -inflammatory drugs (aspirin, diclofenac, dipyron, indomethacin, paracetamol), mental disorders do not increase (refreshing, hysteria, psychotic).

There is no need for special caution when using quinolones with nonsteroidal anti -inflammatory drugs. Ofloxacin absorption is not changed by amoxicillin. The level ofloxacin in serum can be reduced below the concentration of treatment when used simultaneously with aluminum acid and magnesium resistance.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.