OfmanTine - Domesco 1g Treatment of respiratory infections, tonsillitis (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

indication

Treatment in a short time of the following infections:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media.

Lower respiratory infections by H.influenzae and Moraxella Catatrhalis strains produce beta-lactamase: acute and chronic bronchitis, pneumonia-bronchial.

Urinary tract infections - genitals by E. coli strains, klebsiella and enerobacter produce sensitive beta -lactamase: cystitis, urethritis, pyelonephritis (female genital tract infections).

Skin infections and soft tissue such as pimples, abscesses, wound infections.

Bone and joint infections such as osteomyelitis.

Tooth infections such as tooth abscess. Other infections: scales - infections, obstetric infections, abdominal infections.

Pharmacology

Amoxicillin and potassium clavulanat are a combination of bactericidal effects. This coordination does not change the mechanism of the effect of amoxicillin (inhibiting the synthesis of peptidoglycan bacterial cell membrane) but also has the effect of anti-bactericidal, expanding the effect of amoxicillin against many bacteria to create beta-lactamase to inhibit.

Clavulanic acid obtained from the fermentation of Streptomyces Clavuligerus, with beta-lactam structure similar to penicillin nucleus, itself has very weak antibacterial effects and has the ability to inhibit beta-lactamase due to the majority of Gram-negative bacteria and Staphylococcus generated except for Staphylococcus Methicilin

In vitro, clavulanic acid often inhibits staphylococcus penicilinase, beta-lactamase created by Bacteroides fragilis, Moraxella Catatrhalis, beta-lactamase classified according to Richmond and Sykes Type II, III, IV and V. Clavulanic acid can inhibit several types Vulgaris, Bacteroides Fragilis, Burkholderia cepacia but often does not inhibit cephalosporinase transmitted via chromosomes Richmond-Sykes Type I; Therefore, many strains of Citrobacter, Enerobacter, Morganella, Serratia spp., Pseudomonas Aeruginosa is still resistant.

Clavulanic acid can be absorbed through the bacterial cell wall, so it can inhibit the enzyme outside the cell and enzyme attached to the cell. The way that varies depending on the inhibitory enzyme, but clavulanic acid usually works as a dispute and unfavorable inhibitor.

The bactericidal spectrum of the drug includes:

Gram -positive bacteria:

Air -demand: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram -negative bacteria:

Air -favorite type: Haemophilus Influenzae, Moraxella Catatrhalis, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Cholerae, Pasteurella Multocida.

Amoxicilin and potassium clavulanate are easily absorbed by oral and sustainable with stomach acid. The concentration of amoxicillin and clavulanic acid in serum reaches maximum after 1 - 2.5 hours after taking the drug.

Potassium clavulanate does not affect the pharmacokinetics of amoxicillin, but amoxicillin may increase the absorption through the gastrointestinal tract and eliminate the urinary tract for potassium clavulanate compared to the poisonous potassium clavulanate. The absorption of the drug is not affected by food with a common form of preparation.

Distribution:

After drinking, both amoxicillin and clavulanic acid are distributed into the lungs, pleural fluid and peritoneal fluid, passing through the placenta. A small amount of pills found in sputum, saliva and breast milk.

When the meninges are not inflamed, the concentration of the medication in the cerebrospinal fluid is very low, but the larger amount of drugs achieved when the meninges are inflamed. Amoxicillin binds with serum protein about 17-20% and clavulanic acid linked to protein about 22-30%. Oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%.

Era:

Amoxicillin's waste time is 1-2 hours and of Clavulanic Acid is about 1 hour.

After taking single doses of amoxicilin and potassium clavulanate, 50 - 73% amoxicillin and 25 - 45% Clavulanic acid are excreted in urine in the form of unchanged within 6 to 8 hours.

Both amoxicilin and clavulanic acid are removed when hemolysis. When the abdominal dung, clavulanic acid is also removed while only a very small amount of amoxicillin is removed.

Before taking OfmanTine - Domesco 1g Treatment of respiratory infections, tonsillitis (2 blisters x 7 tablets)

How to use

Take pills to swallow the whole tablet (can be broken in half) and not chewed.

Dosage

severe and respiratory infections: 1 tablet 12 hours/time.

Elderly:

No dose adjustments unless creatinine clearance ≤ 30 ml/min.

Children:

Do not use for children under 40 kg of weight.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Abdominal pain, vomiting and diarrhea. A few patients have rash, agitation or drowsiness.

Management:

Need to stop the drug immediately. If occurs early and there is no contraindication, may cause vomiting or gastric wash. Overdose below 250 mg/kg does not cause special symptoms and does not need to clean the stomach.

Interstitial nephritis leads to kidney failure that occurs in a small number of patients using amoxicillin overdose. Urinating crystals in some cases leading to renal failure has been reported after the overdose of amoxicillin in adults and children. Need to provide enough water and electrolytes for the body to maintain the urinary and reduce the risk of urination.

Kidney damage often recovers after stopping the drug. Hypertension can occur even in people with kidney function damaged by reducing the elimination of both amoxicillin and clavulanic acid. You can use the method of hemolysis to remove both amoxicillin and clavulanic acid from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ofmantine, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive system: diarrhea, nausea, vomiting.

Skin and soft tissue: Outdoor, itching.

Uncommon, 1/1000

Blood and lymphatic system: Nothing hypernagus.

Hepatitis system: hepatitis, jaundice, cholestasis, increased transaminase (can be heavy and last for several months).

Reproduction system: Candida vaginitis.

Systemic body: fatigue, headache, fever.

Rare, ADR

The immune system: Anaphylactic reaction, Phu Quincke.

Blood and lymphatic system: A mitigation of platelets, leukopenia, hemolytic anemia.

Reproductive system: fake colitis.

Skin and soft tissue: Stevens-Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning. kidney: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Ofmantine drug is contraindicated in the following cases:

allergies to the beta-lactam group such as penicillins and cephalosporins.

Pay attention to the ability to cross allergies to beta-lactam antibiotics as cephalosporins.

History of jaundice, liver dysfunction due to amoxicillin and clavulanic acid or penicillin because clavulanic acid causes increased cholestatic risk in the liver.

Be cautious when using

Patients with signs of liver dysfunction: Signs and symptoms of cholestasis jaundice, though rarely occurs when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of treatment.

Patients with average or severe renal failure should pay attention to the dosage.

Patients with a history of hypersensitivity to penicillins may have severe reactions or deaths.

Patients with amoxicillin are reddened with lymphadenous fever.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

periodically check hematology, liver and kidney function during treatment. Distinguished diagnosis is needed to detect cases of diarrhea caused by Clostridium difficile and fake colitis. There is a high risk of a rash in patients with monon cells.

The ability to drive and operate machinery

does not affect driving and operating machinery.

Pregnancy

Research on the reproductive process of mice proves that this product is not deformed. However, there is little experience in using drugs for pregnant women, so it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by the doctor.

The period of breastfeeding

during breastfeeding can take the drug. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of medicine in milk.

Interactive drug

Precautions for patients being treated with anticoagulants due to drugs can cause prolonged bleeding and coagulation time.

The drug can reduce the effectiveness of oral contraceptives. So avoid using these combination.

Nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using allopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin and bactericidal stimulants such as fusidic acid, chloramphenicol, tetracyclin. Amoxicillin reduces methotrexate secretion, increases toxicity on the digestive tract and hematopoietic system.

Probenecid reduces amoxicillin excretion leading to increased blood amoxicillin levels. However, Probenecid does not affect the sale time, maximum drug concentration in the blood (CMAX) and the area under the curve (AUC) of Clavuclanic Acid.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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