Ofmantine Domesco 625mg Treatment of respiratory infections, urinary tract - genitals (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

Indications

ofmantine 625 mg is used for treatment in a short time of the following sensitive bacterial infections:

Heavy respiratory infections: tonsillitis , sinusitis, otitis media . E.coli, Klebsiella and Enerobacter strains produce beta - sensitive lactamase: cystitis, urethritis , pyelonephritis (female genital tract infection). Faculty: Total abscess. This combination does not change the mechanism of the effect of amoxicillin (inhibit the synthesis of peptidoglycan bacterial cell membrane) but also has the effect of anti -bactericidal, expanding the effect of Amoxicillin against many bacteria that produce beta - lactamase previously resistant to Amoxicillin, solitary acid Clavulanic has high force and attached to Beta - La La - La processing.

Clavulanic acid obtained from the fermentation of Streptomyces Clavuligerus, has a beta - lactam structure similar to penicillin nucleus, itself has very weak antibacterial effects and has the ability to inhibit beta - lactamase due to the majority of gram -negative bacteria and Staphylococcusss. Clavulanic acid can be absorbed through the bacterial cell wall, so it can inhibit enzymes outside the cell and enzyme attached to the cell.

The antibacterial spectrum of the drug includes

Bacteria of positive:

Aerobic: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebaeterium, Bacillus anthracis, Listeria monocytogenes.

Anaerobic: Clostridioides, peptococcus, peptostreptococcus.

Gram -negative bacteria:

Aerobic: Haemophilus Influenzae, Moraxella Catatrhalis, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Vibrio Cholerae, Pasteurella Multocida.

anaerobic: bacteroides including B.fragis.

Pharmacokinetic

absorption

Amoxicillin and clavulanic acid are easily absorbed by oral and sustainable with the acidic fluid of the stomach. The concentration of amoxicillin and clavulanic acid in the serum reaches maximum after 1 - 2.5 hours of medication. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%.

Distribution

After drinking, both amoxicillin and clavulanic acid are distributed into the lungs, pleural fluid and abdominal fluid , passing through the placenta. A small amount of the drug is found in sputum, saliva and breast milk. When the meninges are not inflamed, the concentration of drugs in cerebrospinal fluid is very low, however, the larger amount is achieved when the meninges are inflamed. Amoxicillin and clavulanic acid linked to serum protein are 17-20% and 22 - 30% respectively.

Elimination

Amoxicillin's waste time is 1-2 hours and of Clavulanic Acid is about 1 hour. After taking the single doses of Amoxicillin and Clavulanat Potassium in adults with normal kidney function, 50 - 73% Amoxicillin and 25 - 45% of Clavulanic Acid are excreted in urine in a constant form within 6 - 8 hours. Both amoxicillin and clavulanic acid are removed when hemolysis. When abdominal distances, clavulanic acid is also removed while only a very small amount of amoxicillin is removed.

Before taking Ofmantine Domesco 625mg Treatment of respiratory infections, urinary tract - genitals (2 blisters x 7 tablets)

How to use

oral drugs. Take the medicine at the beginning of eating to minimize the phenomenon of non -tolerated drugs in the stomach - intestines. Do not take the drug for more than 14 days without checking the treatment.

Dosage

Adults and children over 40 kg

Use 1 capsule 2 times/day.

Severe infections and respiratory infections: 1 tablet x 3 times/day x 5 days.

Elderly

No need to adjust the dose unless creatinine clearance is ≤ 30 ml/min.

Do not use for children under 40kg.

In case of kidney failure in adults and children over 40 kg, it is necessary to reduce the dose accordingly:

Creatinine clearance> 30 ml/min: No dose adjustment.

Creatinine clearance 10 - 30 ml/minute: 1 capsule 2 times/day.

Creatinine clearance

Hemolysis: 1 tablet x 1 time/day, drink during and after the divergence.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? If occurs early and there is no contraindication, may cause vomiting or gastric wash. Overdose below 250 mg/kg does not cause special symptoms and does not need to clean the stomach. Need to provide enough water and electrolytes for the body to maintain the urinary and reduce the risk of urination.

Can use blood decentralization method to remove both amoxicillin and clavulanic acid from circulation.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using ofmantine 625mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

BOD (appear slow after 7 days of treatment).

Nausea, vomiting, epigastric pain, diarrhea in adults, higher rate in children and the elderly (loose stools in 42% of children under 8 months, 20% in children 8 - 16 months and 8.5% in children 24 - 36 months).

Uncommon, 1/1000

Redders, lumpy and urticaria, especially Stevens - Johnson syndrome.

Incretion.

hepatitis, jaundice, transaminase.

Candida vaginitis .

Headache, fever, fatigue.

Rare, 1/10000

Increase slightly SGOT (AST).

excited, struggling, anxiety, insomnia, confusion, changes in behavior or dizziness.

Clostridioides varicile colitis, acute colitis with symptoms of abdominal pain and bloody diarrhea, not related to Clostridioides Difficile.

Platelet hemorrhage committee, eosinophilia loves Eosin, granulocytes, platelets, leukopenia, hemolytic anemia.

Anaphylactic reaction, Phuincke, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning.

Interstitial nephritis.

Instructions on how to handle ADR

Amoxicillin's undesirable reactions in the gastrointestinal tract, in blood often disappear when stopping treatment.

urticaria, other types of rash and serum -like reactions can be treated with antihistamine, and if necessary, using systemic corticosteroid therapy. However, when such a reaction occurs, amoxicillin must be stopped, unless there is a doctor's opinion in special cases, life -threatening that only Amoxicillin can resolve.

If the allergic reaction occurs such as erythema, edema, anaphylaxis, Stevens - Johnson syndrome, amoxicillin must be stopped and immediately emergency emergency with adrenaline, oxygen breathing, intravenous corticosteroid therapy, including internal trachea and never being treated with penicillin or cephalosporin.

Palmitis: If mild, stop the drug. In severe cases (the ability by Clostridioides Difficile), water supplementary, electrolytes and proteins, using antibiotics to treat Clostridioides (Metronidazole, Vancomycin).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ofmantine 625 mg contraindicated in the following cases:

allergies to the beta - lactam group (penicillin and cephalosporin) and other ingredients of the drug.

Pay attention to the ability to cross allergies to beta - lactam antibiotics as cephalosporin.

Be cautious when using

people with a history of jaundice, liver dysfunction caused by amoxicillin and clavulanic acid or penicillin because clavulanic acid causes increased cholestatic risk in the liver. Signs and symptoms of cholestasis jaundice are rarely occurring when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of treatment.

For average or severe kidney failure, the dose adjustment should be noted.

For patients with a history of hypersensitivity to penicillin may have severe reactions or deaths. Before starting to use amoxicillin, it is necessary to carefully investigate a history of allergies to penicillin, cephalosporin and other allergens.

Patients with amoxicillin use redness with lymphadenous fever.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Periodically check hematology, liver and kidney function during treatment. Distinguished diagnosis is needed to detect cases of diarrhea caused by Clostridioides Difficile and fake colitis. There is a high risk of a rash in patients with monon cells.

The ability to drive and operate machinery

The drug can cause dizziness (rare) effect. Be cautious when driving and operating machinery.

Pregnancy

Experimental research on the reproductive process of mice proved when using non -deformed preparations. However, because there is little experience in using drugs for pregnant women, it is necessary to avoid using the drug in this object, especially in the first 3 months, except for the necessary case prescribed by the doctor.

Breastfeeding period

during breastfeeding can be used. The drug is not harmful to breastfeeding, unless there is a risk of sensitivity due to a very small amount of medicine in breast milk.

Medicinal interaction

Caution for patients being treated with anticoagulants (warfarin) because the drug can cause prolonged bleeding and blood clots.

Like antibiotics with broad spectrum, the drug can reduce the effectiveness of oral contraceptives. Therefore, avoid using these combinations.

Nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using allopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin and bactericidal bacteria such as fusidic acid, chloramphenicol, tetracycline.

Amoxicillin reduces methotrexate secretion, increases toxicity on the digestive tract and hematopoietic system.

Probenecid taken right before or simultaneously with amoxicillin reduces amoxicillin elimination, thereby increasing the concentration of amoxicillin in the blood. However, Probenecid does not affect the sale time, the maximum concentration of the drug in the blood (CMAX) and the area under the curve of drug concentration over time in the blood (AUC) of Clavulanic Acid.

Storage

In a dry place, temperatures below 30ºC, avoid light.

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