Okynzex US Pharma drugs treat symptoms of neurological disorders, memory disorders, centralized decline (30 packs x 6g)

Dosage form 30 package box
Specifications Piracetam

Ingredient

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Composition information	Content
Piracetam	2400g

Uses

indications

Okynzex drug prescribed treatment in the following cases:

Treatment of chronic neurological disorders in the case of overall treatment for dementia syndrome with the main symptoms such as memory disorders, centralized decline, thinking disorders, fatigue and lack of alertness, emotional disorders. The main group of subjects includes patients with dementia syndrome with Nguyen Phat memory loss, dementia many times and the mixed forms of both of the above syndrome.

Individual response to unpredictable drugs.

Note: Before starting piracetam treatment, it is necessary to clarify whether the symptoms are caused by a specific disease.

Additional treatment in muscle shock syndrome.

Treatment supports post -traumatic syndrome with the main symptoms of dizziness and headache (post -shocking state).

Pharmacology

Pharmacological group: nervous system, mental medicine, mental stimulant and other Nootropics. ATC code: N06bx03.

In animal experiments, piracetam improves the decline in brain metabolism by stimulating oxidation glucose decomposition through pentose phosphate sugar, increasing ATP amounts, increasing Camp levels in neurons, adenyl kinase stimulation, stimulating phospholipid metabolism by increasing 32P into phosphate. Promote protein biosynthesis and increase the rotation of cytochrom B5 respiratory enzymes in oxygen deficiency.

Piracetam causes an increase in m-cholinoreceptor levels and increases dopamine changes in old animals. It promotes the transmission and transmission of stimulation in different brain regions with the improvement of EEG energy spectrum.

In EEG studies, the amplification of alpha components with a decrease in theta and delta components has been mentioned.

In patients, Piracetam affects the ability to study and disturbed memory.

In addition, Piracetam has the effect of reducing platelet capacitors, reducing the viscosity of plasma and in case of abnormal hard red blood cells, the drug can cause red blood cells to recover the ability to deform and pass through capillary.

Dynamic pharmacokinetics

absorption: Piracetam is absorbed quickly and almost completely after drinking. The relatively 100% biopsy is 100% (800 mg of piracetam as a single dose) compared to the AUC value after intravenous injection. CMAX is achieved after 30 minutes (TMAX): 15 - 19 g/ml. Regardless of the plasma treatment regime, the average selling time is 5.2 hours (4.4 to 7.1 hours) or 7.7 hours in cerebrospinal fluid. According to In vitro investigation, Piracetam is linked to about 15% of plasma proteins.

The distribution volume is about 0.6 l/kg.

Suman clearance in plasma is about 120 ml/min. The metabolites have not been found until the present time.

In cases of renal failure, the excretion is delayed, so to avoid the effect of accumulating drugs, the reduction of dose according to nitrogen or creatinine values is necessary. Piracetam can separate up to 50-60%.

Piracetam penetrates the placenta and can be detected in the fetus's plasma as well as amniotic fluid (43 patients, 2.4 or 6 g of piracetam from 2 to 3 hours before birth). The fetal plasma concentration is about 10-30% lower than the mother. However, the time of semi -discharged in plasma in newborns is nearly twice as long as a mother after 200 minutes (98 - 112 minutes). Piracetam transmitted through breast milk.

Birth: Piracetam absorbs 100% when used by oral.

Clinical safety data:

Preceptic data is based on pharmacological studies and safety toxicity including gene poisoning, cancer and reproductive toxicity, showing no special danger to humans.

Before taking Okynzex US Pharma drugs treat symptoms of neurological disorders, memory disorders, centralized decline (30 packs x 6g)

How to use

The drug used by oral, preparations should be taken immediately after completely dispersed in liquids (such as water), drink during or immediately after meals.

The doctor will determine the treatment time.

During the support treatment process of intellectual dementia syndrome, after three months, it is necessary to check if the next treatment is still appropriate.

The duration of complementary treatment of muscle vibration syndrome is derived from the cortex depending on the clinical process. If muscle vibration syndrome is no more, then the treatment with Piracetam may gradually end.

The treatment support for postoperative syndrome should be performed for at least three months.

Dosage

Dosage depends on the type and severity based on the clinical manifestation of the disease and the patient's response ability to the therapy.

For adults, the following drug tutorial is applied to treat intellectual dementia syndrome:

1 pack of Okynzex (equivalent to 2.4 g of piracetam) is taken once a day. According to the doctor's special appointment, the dose can be increased twice a day (equivalent to 4.8 g of piracetam).

For supplementary treatment of muscle vibration syndrome of cerebral cortex, the following dose indications are applied to adults:

When starting therapy, use 7.2 g of piracetam (equivalent to 3 packs). Then, depending on the reaction, every 3-4 days of increasing the daily dose by 4.8 g (equivalent to 2 packs). The maximum daily dose is 24 g (equivalent to 10 packs), divided into 2 to 3 doses only.

Other drug treatments, with the agents affecting myocardial muscle, should be continued with constant doses. Depending on the clinical response, this drug may then be gradually reduced, if possible.

After starting treatment, it is necessary to continue treating if the initial breeding still exists. In patients with acute cardiomyopathy, spontaneous remission may occur over time. Piracetam dose should be reduced by 1.2 g every two days (or every 3-4 days in case of Lance -adams syndrome) to prevent the possibility of recurrence or seizures due to sudden stopping of drugs.

For adults, the following drug's instructions are applied to treat after surgery syndrome:

1 pack of Okynzex (equivalent to 2.4 g of piracetam) once a day. According to the doctor's special appointment, the dose can be increased to 2 packs (equivalent to 4.8 g of piracetam) twice a day.

Adjust the dose in elderly patients:

In elderly patients with renal failure, dose adjustment should be adjusted. Regular consideration of creatinine clearance during long -term treatment in elderly patients to adjust the dose when necessary.

Adjust the dose in patients with renal function:

Because Piracetam is only excreted through the kidneys, it can lead to increased plasma concentrations when the kidney function decreases. Therefore, the daily dose must be determined separately depending on the kidney function. Adjusting the dose should be made according to the following table. To do this, the patient's creatinine clearance (CLCR) must first be estimated by ml/min. CLCR is in ml/minute that can be determined from serum creatinine (mg/ml) according to the following formula:

CLCR = [140 - Age (year)] x Weight (kg)/72 x Serum creatin level (mg/dl) x [0.85 (in women)]

50 - 79 2/3 of the normal daily dose, 2 or 3 single dose medium

30 - 49

1/3 of the normal daily doses, only 2 unique doses 30 1/6 normal daily dose, 1 single dose

Piracetam is not metabolized in the liver. For patients who only have liver function reduced, do not apply special dosage instructions. In patients with liver and renal failure, dose adjustment should be adjusted.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

There have not been unwanted effects due to the overdose of the drug reported to Piracetam.

The highest piracetam overdose is reported as 75 g. A case of bloody diarrhea along with abdominal pain when using a dose of 75 g of piracetam/day, and most are related to too high amounts of sorbitol in the form of preparation.

Management:

In case of acute overdose, the stomach can be empty by gastrointestinal or vomiting. There is no specific detoxifying antid for overdose of Piracetam. Overdose treatment includes symptomatic treatment and dialysis. Dialysis helps remove about 50 - 60% of piracetam from the body with a period of 4 hours.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Data collected in double clinical studies and pharmacological studies, including safe data that can be determined, including 3,000 people involved in the study using Piracetam regardless of the designated dose, daily dose, daily dose or population characteristics.

Unwanted effects are reported in clinical trials and since the drug is circulated on the market, listed below according to the organs and frequency.

The unwanted frequency of unwanted effects is classified as follows: Very common (> 1/10); Common (1/10> ADR ≥ 1/100); Rarely (1/100> ADR ≥ 1/1000); Rarely (1/1000> ADR ≥ 1/10000); Very rare (ADR

Common, 1/10> ADR ≥ 1/100

Mental: suspense, aggression, sleep disorders.

Mental: Depression

Skin and subcutaneous tissue: Skin red and hot feeling.

Blood and lymphatic system: Hemorrhagic disease face. In children, unwanted effects have been observed at the dose of 3 g of piracetam every day.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Okynzex drug contraindicated in the following cases:

Hypersensitivity to Piracetam or other Pyrrolidon derivatives or any ingredients of the drug. Creatinin remaining.

Be cautious when using

Piracetam should only be used related to all necessary preventive measures in cases of mental agitation.

Affects platelet collection

Because Piracetam affects platelet collection, it is necessary to be cautious when using Okynzex in patients with coagulation disorders, bleeding, such as hemostasis in the case of stomach ulcers, large surgical procedures including dental surgery, severe hemorrhage, hemorrhagic history, brain vascular accident and patients using anticoagulant drugs or inhibitors of plague.

Kidney function is limited

Because Piracetam is excreted through the kidneys, it is especially cautious when used for patients with renal impairment (see the dosage and usage).

Elderly patients

For long -term treatment for elderly patients, regularly checking creatinine to adjust the dose when necessary (see the dosage and usage).

End of treatment

In patients with myasthenia gravis, it is advisable to avoid the end of the sudden treatment because this can lead to recurrence or seizures related to epilepsy.

Patients who are taking anti -convulsions should be ensured that this therapy will be maintained, even if there is a subjective improvement in Piracetam treatment.

Using drugs for women during pregnancy and lactation

Using drugs for pregnant women:

There is no adequate data on the use of piracetam during pregnancy. Animal reproductive toxicity studies have not given any evidence of other Piracetam's teratogenic or embryonic properties.

Piracetam passes through the placenta fence. The fetal plasma contains about 70-90% of the mother's plasma concentrations. Piracetam should not be used during pregnancy, unless the benefits are greater than the risk and clinical status of pregnant women, it is necessary to be treated with piracetam.

Use medicine for breastfeeding women:

Piracetam is excreted into breast milk. Therefore, piracetam should not be used during breastfeeding or breastfeeding should stop treating with piracetam. Need to consider the benefits of breastfeeding for infants and the benefits of treatment for mothers when deciding to stop breastfeeding or piracetam treatment.

The effect of the drug on the ability to drive and operate machinery

Due to the unwanted effects of Piracetam's observation, it is impossible to rule out the possibility of decline, so it is necessary to be careful to use the drug when driving and operating machinery.

Drug interaction

Mobile interactions

The ability to interact with drugs affects the dynamics of low piracetam, because about 90% of the dose is excreted in the form of unchanged urine.

In concentrations 142, 426 and 1422 PG/ml, piracetam does not inhibit cytochrom P450 ISOENZYM CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 and 4A9/11 in vitro.

At 1422 PG/ml, the small inhibitor has been observed on the ISOENZYM CYP 2A6 (21%) and 3A4/5 (11%). However, the ki value for the inhibition of these two isenzyme is higher than 1422 PG/ml. Therefore, piracetam's metabolic interaction with other drugs does not seem to occur.

thyroid hormone

Confusion, discomfort and sleep disorders have been reported when used simultaneously piracetam with thyroid hormones (T3 + T4).

In a simple study published in patients with severe, recurrent venous thrombosis, 9.6 g of Piracetam per day does not affect the dose of AcenVitymarol needed to reach 2.5 to 3.5. Compared to the effect of acenvitymarol, the use of 9.6 g of piracetam every day significantly reduces platelet aggregation, releases β-thromboglobulin, fibrinogen levels and the elements of Willebrand (VIII: C; VII: VW: AG; VII: VW: RCO), the viscosity of whole blood and plasma blood and plasma.

Anti -epileptic drugs

When using piracetam at a dose of 20 g/day for 4 weeks does not change the peak concentration and bottom concentration of anti -epileptic drugs (carbamazepin, phenytoin, phenobarbiton, valproot) on seizures are using stable doses.

Central nervous system stimulant/Neurology

Effects of central nervous system stimulants and nerve drugs can be enhanced.

Alcoholic beverages

Concomitant use with alcoholic beverages does not affect piracetam levels in serum and piracetam at a dose of 1.6 g nor changes alcohol content.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoid light.

Other drugs

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