Olevi Olopatadine 5ml Merap eye drops for the itchy eye of allergic conjunctivitis

Dosage form 1 bottle box
Specifications Olopatadine

Ingredient

Composition information	Content
Olopatadine	0.2% W/V

Uses

indications

Oleved drugs are indicated in the following cases:

Treatment of the itchy symptoms of allergic conjunctivitis. anti -congestion and anti -allergic drugs; Anti -allergy.

ATC code: S01GX09

olopatadine is a selective anti -hype and antihistamine, which works through many separate operating mechanisms.

olopatadine antihistamine (the first intermediate of allergic reactions in humans) and prevent cytamines from producing cytokin causing inflammation from human conjunctival epithelial cells. Data from In vitro studies show that olopatadine can affect human conjunctiva cells to inhibit the release of inflammatory mediators.

Dynamic pharmacokinetics

absorption

There is no data on bioavailability when the eye is 0.2%. After the eye drops the olopatadine solution 0.15% in humans, the drug absorbs the whole body very little. Two studies on healthy volunteers (a total of 24 people) are small at the eyes of 0.15% olopatadine solution every 12 hours in 2 weeks, indicating that the drug concentration in plasma is largely under the quantitative limit (

metabolism and elimination

The half -life of the drug in plasma after oral use is about 8 to 12 hours, and the excretion is mainly through the kidneys. About 60% - 70% of the dose found in urine in non -metabolic form. Two metabolites Mono-Desmethyl and N-Oxid are detected in low concentrations.

Before taking Olevi Olopatadine 5ml Merap eye drops for the itchy eye of allergic conjunctivitis

How to use

tilt your head back. Put a finger under the eyes, gently pull down the eyelids down until the lower eyelid and the eyeball forming a V -shaped bag. Set. Hold your eyes closed for 1 or 2 minutes to chew the medication in the air, the corneal wet.

To avoid infection into the small tip of the drug and the drug, it is necessary to be careful not to let the small tip touch the eyelids, the surrounding area or other surfaces. Close the lid after use.

Remove contact lenses before use.

Dosage

recommended dose: 1 drop at a time on each eye to be treated, once a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

In case of overdose, patients need to be monitored and monitored appropriately

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Oleved eye drops, you may experience unwanted effects (ADR):

The following unwanted effects are reported in clinical studies and Olopatadine eye drops. The defined frequency is: very common (≥ 1/10), common (≥ 1/100 to Infections and parasites

Uncommon: rhinitis.

immune system disorders

Not known: Hypersensitivity, face swelling.

Nervous system disorders

Common: headache, taste disorders.

Common: eye pain, itchy eye, dry eyes, irregular sensation in the eyes. Eyelid, eyelid disorders, eye congestion.

Common: Dry nose.

Digestive disorders

Unknown: Difficulty breathing, sinusitis.

Not known: Nausea, vomiting.

Less: contact dermatitis, skin burning sensation, dry skin.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Olevid eye drops in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Only small eyes. Do not inject or oral. When not in use, the lid of the patient should not be tightly covered with contact lenses if the eye is red. Contact lenses need to be removed before taking the drug and wait at least 15 minutes later to wear glasses again.

The effect of the drug on driving and operating machinery

Oleved does not affect or affect the ability to drive and operate machinery. After vision medicine may be temporarily unstable. Do not drive, use machinery or do any activity that requires a clear view, until it is sure to perform normal activities.

Use drugs for women during pregnancy and lactation

Pregnant women

There is no data on drug use in pregnant women, should only be used if the benefits are superior to the risk

breastfeeding women

olopatadine was found in the mother's milk mouse milk using oral olopatadine. It is not known whether the eye drops can absorb the whole body so much that it produces a significant amount of drugs in breast milk, so it is necessary to be careful to use Oleved in breastfeeding women.

Drug interaction

no interactive studies have been conducted.

In vitro studies show that olopatadine does not inhibit the reactions of isozyme cytochrome P-450 1A2, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4. Therefore, olopatadine does not affect the metabolism of drugs metabolized by the above enzymes.

In case of simultaneous use with other eye drops, two drugs should be separated at least 15 minutes apart. Eye ointment should be used final.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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