Olmed 5mg Actavis tablets treat schizophrenia (4 blisters x 7 tablets)
Dosage form Box of 4 blisters x 7 tablets
Specifications Olanzapine
Ingredient
| Composition information | Content |
| Olanzapine | 5mg |
Uses
indications
Olmed drug is indicated in the following cases:
olanzapine is an anti -psychotic drug, anti -manic and stabilized mood to show a wide pharmacological activity on some receptors.
pharmacokinetic
absorption
olanzapine is well absorbed after drinking, reaching a plasma peak concentration within 5 - 8 hours. Absorption is not affected by food. Absolute oral bioavailability compared to unprespable intravenous lines.
Distribution
About 93% olanzapine is connected to plasma proteins when the concentration is from 7 to 1,000 ng/ml. Olanzapine is mainly connected to albumin and α1 - acid - glycoprotein.
Metabolism
olanzapine is metabolized in the liver through a conjugate and oxidative mechanism. The main metabolites in the circulation are 10 - n - glucuronide, this substance does not go through the brain barrier. Cytochromes P450 - CYP1A2 and P450 - CYP2D6 are involved in the creation of N - Desmethyl and 2 metabolites - Hydroxymethyl. Both metabolites have lower pharmacological activity in vitro than olanzapine in animal studies. Pharmacological effects are mainly caused by olanzapine.
Elimination
After drinking, the average selling time of olanzapine in healthy people varies with age and gender.
Before taking Olmed 5mg Actavis tablets treat schizophrenia (4 blisters x 7 tablets)
How to use
Olmed drugs are taken orally.
Dosage
Adults
schizophrenia:
The starting dose of olanzapine is recommended for 10 mg/day.
Halfy:
The starting dose is 15 mg once daily in single therapy or 10 mg daily in combined therapy.
Prevention of recurrence in bipolar disorders:
The recommended starting dose is 10 mg/day. For patients who have used olanzapine to treat manic attacks, it is advisable to continue treating prophylaxis at the same dose. If a new mania occurs, a mixture or a depression, it is advisable to continue treating olanzapine (with the optimal dose if necessary), with additional therapy to treat mood symptoms as clinically indicated.
During the schizophrenia treatment, the impellance and prevention of bipolar disorders, which can be adjusted daily for the next days based on the clinical condition of each patient within the limit of 5 - 20 mg/day. The increase in the starting dose is recommended only after the appropriate clinical re -evaluation and usually at no less than 24 hours.
Using olanzapine may not need to care about the meal because the absorption is not affected by food. Should consider reducing the dose gradually when stopping olanzapine.
Children
olanzapine does not recommend used for children and teenagers under 18 years of age due to lack of data on validity and safety. In short -term studies, weight gain, lipid changes and prolactin in teenagers are larger than patients in adulthood.
Old people
The starting dose is lower (5 mg/day) is not prescribed regularly but should consider patients over 65 years old when clinical factors are allowed.
kidney failure and/or liver failure
The starting dose is lower (5 mg/day) should consider these patients. In case of medium liver failure (cirrhosis, Child - Pugh A or B), it is advisable to start at a dose of 5 mg/day and caution when increasing the dose.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Signs and symptoms
The most common overdose (10%ratio) includes tachycardia, agitation/aggression, vanity disorders, different symptoms of pagoda, reducing consciousness to coma.
Other severe sequelae of overdose include delirium, convulsions, coma, may have malignant neurolithic syndrome, respiratory inhibition, hypertension or hypotension, arrhythmia ( Handling overdose
There is no specific antidote to olanzapine. Causing vomiting is not recommended. Can considers the standard overdose process (such as gastric lavage, activated carbon). Simultaneous use of activated carbon reduces oral bioavailability of olanzapine from 50% to 60%.
should conduct symptomatic treatment and monitor the function of the survival organ according to clinical manifestations, including the treatment of hypotension and circulation and respiratory function.
Do not use epinephrine, dopamine, or other beta sympathetic sympathetic drugs due to the stimulation of beta can lower blood pressure. Cardiovascular monitoring is needed to detect possible arrhythmia. Should continue monitoring and closely monitoring until the patient recovers.
In an emergency, call the 115 emergency center immediately or go to the nearest local health station.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using olmed drugs, you may experience unwanted effects (ADR).
Very popular (ADR> 10%)
Popular (1% to
urinary tract.
Mobility disorders. Mild, fleeting anti -cholinergic anti -constipation and dry mouth, increased ALT, asymptomatic AST, especially in early treatment. fit. Not common (0.1% to 1%) Neutral leukopenia. QTC lasts. Sensitive to light. Unknown (not estimated from available data) The worse of diabetes is sometimes associated with ceton acid infection or coma, some deaths. Malignant neuropular syndrome. Late movement disorders. Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Olmed drugs contraindicated in the following cases:
Precautions when used
During the treatment of anti -psychotic drugs, improving the clinical condition of the patient may take several days to several weeks. Patients should be closely monitored during this time.
Intellectual dementia is related to mental disorders and/or behavioral disorders: olanzapine is not approved to treat intellectual dementia associated with mental disorders and/or behavioral disorders and is not recommended for use for this group of patients due to increased mortality and increased risk of cerebrovascular artery.
Parkinsion disease
There is no recommendation to use olanzapine for Parkinson patients.
Malignant neuronal syndrome (NMS)
NMS is a life -threatening condition associated with the treatment of anti -psychotic drugs. There are very few reports on cases of NMS related to olanzapine.
Hyperglycemia and diabetes
Should follow appropriate clinical monitoring according to the instructions for using anti -psychotic drugs. Patients treated with any anti -psychotic drugs, including Olmed film tablets, should be monitored with signs and symptoms of hyperglycemia (drinking, urinating, eating a lot, and losing weight), and patients with diabetes or risk factors for diabetes should be monitored regular blood sugar control. Should monitor regular weight.
Lipid changes
Patients treated with any anti -psychotic drugs, including Olmed film tablets, should be monitored regularly under the instructions for using anti -psychotic drugs.
Cholinergic resistance activities
Be careful when used for patients with prostate hypertrophy, intestinal paralysis and related conditions.
Liver function
In air, no symptoms of liver, ALT, AST aminotrans, AST, especially in early treatment. Be cautious and monitor in patients with hypertension and/or AST, patients with signs and symptoms of liver failure, patients have conditions that limit the liver reserve function before, and in patients being treated with drugs that can poison the liver. In the case of hepatitis (including liver, cholest liver or mixed liver damage), which is diagnosed, should be discontinued with olanzapine.
leukopenia
Be careful in patients with reduced number of leukemia and/or neutrophils due to any cause, in patients who use medications that cause neutropenia, patients with a history of drugs that inhibit/toxic bone marrow, patients inhibiting bone marrow due to simultaneous diseases, radiation or chemotherapy and patients with eosinophilia or oythsis hyperpathy. Leukopenia is often reported when used simultaneously olanzapine with valproate.
Discount
Acute symptoms such as sweating, insomnia, tremor, anxiety, nausea or vomiting are reported very rare ( About qt
As with other anti -psychotic drugs, should be cautious when using olanzapine with drugs that increase QTC, especially in the elderly, patients with congenital QT syndrome, congenital heart failure, heart hypertrophy, hypotension or hypoglycemia.
Venous thrombosis
Cases of venous thrombosis have been reported to anti -psychotic drugs. Because patients treating psychotic drugs often have dangerous venous thrombosis factors, all these risk factors should be identified before and during treatment with olmed and take precautions.
Activity on the central nervous system
Based on the effects of olanzapine on the central nervous system, should be cautious when used with alcohol and other central impact drugs.
epilepsy
Should be carefully used olanzapine in patients with a history of epilepsy or easily affected by factors that can reduce epilepsy threshold.
Late movement disorders
If the signs or symptoms of late movement disorders appear in patients using olanzapine, should consider reducing the dose or stopping treatment. These symptoms may temporarily deteriorate or even appear after treatment.
posture hypotension
posture hypotension is often recorded in the elderly in clinical trials with olanzapine. Like other anti -psychotic drugs, it is recommended to measure blood pressure periodically in patients over 65 years old.
Suddenly due to heart
In the reports after use with olanzapine, the sudden death event due to the heart has been reported in patients using olanzapine.
Children
olanzapine is not indicated for use in the treatment of children and adolescents.
lactose
Olmed film tablets contain lactose. Patients with rare genetic problems without galactose, Lactase Lapping Lapp or Glucose - Galactose should not be used.
soy lecithin
If the patient is too sensitive to peanuts or soybeans, this drug should not be used.
The ability to drive and operate machinery
There is no research on influence on the ability to control train and operate machinery. Because olanzapine can cause drowsiness and dizziness, patients should be warned of machinery operation, including motor vehicles.
Pregnancy
There is no enough research in pregnant women. Patients should notify the doctor if pregnant or intend to get pregnant during treatment with olanzapine. However, because studies are limited, olanzapine should only be used during pregnancy when the benefits are greater than the potential risk to the fetus.
Breastfeeding period
Patients should not breastfeed if they are taking olanzapine.
Drug interaction
Interactions affect olanzapine
Because olanzapine is metabolized by CYP1A2, these substances that can be stimulated or inhibited inhibitors can affect the pharmacokinetics of olanzapine.
Stimulating enamel CYP1A2
The metabolism of olanzapine may be stimulated by smoking and carbamazepine, which can lead to reduced olanzapine levels. Only increases the olanzapine clearance to moderate to moderate. Clinical consequences may be limited, but clinical monitoring and may consider increasing olanzapine dose if necessary.CYP1A2 inhibitors
Fluvoxamine, a specialized CYP1A2 inhibitor, has been shown to inhibit the metabolism of olanzapine significantly. Lower starting dose should be considered in patients who are using fluvoxamine or any other CYP1A2 inhibitors, such as Ciprofloxacin. Olanzapine dose should be considered for treatment with a CYP1A2 inhibitor.
Reduce bioavailability
Activated carbon reduces olanzapine oral bioavailability from 50 to 60% and should be used at least 2 hours before or after using olanzapine.
Fluoxetine (a CYP2D6 inhibitors), the only dose of antacids (aluminum, magnesium) or cimetidine does not significantly affect the pharmacokinetics of olanzapine.
The influence of olanzapine on other drugs
olanzapine can oppose the effect of direct and indirect dopamine drug owner.
Activity on the central nervous system.
Should be cautious in patients drinking alcohol or using central nervous system inhibitors.
Concomitance the use of olanzapine with Parkinson anti -Parkons in patients with Parkinson's disease and dementia is not recommended.
About QTC: Be careful when using olanzapine simultaneously with drugs that increase the QTC.
Storage
Store no more than 30 ° C in the original packaging to avoid light and avoid moisture.
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