Omeprazol hard capsules 20mg Domesco treat gastroesophageal reflux - esophagus (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

indications

omeprazol drugs are indicated in the following cases:

Gastroesophageal - esophagus.

Treatment of peptic ulcer. Esomeprazoi.

Omeprazole inhibits the excretion of the acidic acid secretion due to inhibiting the enzyme system Hydro/Pot Omeprazol does not work on receptor (receptor) acetylcholine or histamine receptor. Take a single dose of 20 mg of omeprazole to create a strong and effective stomach acid secretion. The maximum effect is achieved after 4 days of treatment in patients with stomach ulcers, which can maintain a 80% reduction in gastric acid in 24 hours.

Omeprazol can restrain Helicobacter pylori bacteria in patients with duodenal ulcer and/or reflux esophagitis infected with this bacteria. Combining omeprazol with some antibacterial drugs (for example, clarithromycin, amoxicillin) can be exposed to H.pylori accompanied by an ulcer and remission.

Dynamic pharmacokinetics

absorption: Omeprazol is completely absorbed in the small intestine after drinking for 3 to 6 hours. Food does not affect the absorption of drugs in the intestine. Omeprazol is destroyed in acidic environment.

Distribution: The drug attaches about 95% to plasma proteins.

Metabolism: Omeprazole is almost completely metabolized in the liver, mainly thanks to the isenzyme CYP2C19 of Cytochrom P450 and a small part metabolized through CYP3A4.

Elimination: After metabolism, substances do not have the activity that is excreted mainly through urine, partly through stool. Semi -selling time in short plasma but the drug has a long time (due to the prolonged attachment of the drug to H+/K+ ATPASE).

Before taking Omeprazol hard capsules 20mg Domesco treat gastroesophageal reflux - esophagus (10 blisters x 10 tablets)

How to use

omeprazol 20mg used by oral, orally in the morning.

Dosage

recommended dose:

Treatment of esophagitis due to gastroesophageal reflux disease: The common dose is 20 - 40 mg/day once a day, over 4-8 weeks, then it can be maintained at a dose of 20 mg/day.

ulcerative treatment: take a dose of 20 mg/day 1 time (case weighs 40 mg) for 4 weeks if it is duodenal ulcer, for 8 weeks if it is a stomach ulcer. Do not use longer than the above time.

Treatment of Zollinger - Ellison syndrome: Take the dose of 60 mg/day once a day (20 - 120 mg daily), if the dose is higher than 80 mg, divide it 2 times daily. The dosage should be calculated for specific cases and the therapy may last depending on the clinical requirements. Do not stop the drug suddenly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? When overdose, only symptomatic treatment, no specific treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Omeprazol 20mg domesco, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: headache, drowsiness, dizziness.

Uncommon, 1/1000

Neurological: Insomnia, sensory disorders, fatigue;

Skin: urticaria, itching, rash; ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Omeprazol drugs are contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

omeprazole can hide symptoms and slow down the diagnosis in patients with malignant damage in the stomach.

Using drugs may increase the risk of gastrointestinal infections (for example, Salmonella infection, campylobacter).

Omeprazol used for prolonged use can increase the risk of infection, fracture especially in the elderly.

Using omeprazol for a long time can reduce blood magnesium, so you must monitor the magnesium concentration in plasma when taking the drug.

omeprazol is a CYP2C9 inhibitor, when starting and ending treatment with omeprazol should consider the ability to interact with metabolic drugs through CYP2C19 (like clopidogrel).

Lupus erythematosus in the skin: Proton pump inhibitors are associated with IUPUS erythema, if the damage occurs, especially in the place of contact with light, accompanied by joint pain. Should notify the doctor to stop drinking omeprazoi.

The ability to drive and operate machinery

The drug can cause dizziness, drowsiness so cautious when driving and operating machinery.

pregnancy

using omeprazol during pregnancy is only considered when it is really necessary because there is no data on the toxic effect of the drug on the fetus.

Breastfeeding period

The drug distributed in breast milk should consider stopping the drug or stop breastfeeding.

Drug interaction

omeprazol may increase the concentration of cyclosporin in the blood.

omeprazol increases the effects of antibiotics in eradication H. pylori.

Metabolic inhibitor of drugs metabolized by the liver's cytochrom P450 enzyme system and may increase the concentration of diazepam, phenytoin and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer. Omeprazol doses 20mg/day have weak interactions, inhibit metabolism of phenytoin and increase the concentration of phenytoin in blood less than 40 mg/day.

omeprazol increases Dicoumarol's anticoagulant effect.

Nifedipine metabolism reduces at least 20% and may increase the effects of nifedipine.

Clarithromycin inhibits omeprazol metabolism, doubling Omeprazole concentration.

Omeprazol reduces the acid of the stomach, so it affects (increase or decrease) of the absorption of drugs that the absorption depends on the stomach pH.

Concentrated with Atazanavir with proton pump inhibitors reduces the level of Atazanavir in plasma, so the dose of Atazanavir must be increased to 400 mg and ritonavir 100mg (omeprazol not more than 20 mg).

The interaction between clopidogrel and omeprazol will reduce contact with active metabolites.

Due to the sharing of omeprazol with tacrolimus may increase the concentration of tacrolimus in the serum.

Long -term use can reduce the absorption of vitamin B12 (cyanocobalamin)

Simultaneous use Omeprazol with Posaconazole, Erlotinib, Ketoconazole and Itraconazole The absorption decreases, thus reducing the effect of those drugs.

Methotrexate: When used with proton pump inhibitors, the concentration of methotrexate can increase in some patients.

Storage

Store in a dry place, the temperature does not exceed 30ºC, avoiding light.

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