Omeprazol tablets TVP 20mg treat duodenal ulcer, stomach ulcer (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

indications

omeprazol TVP 20mg is indicated in the following cases:

Adults:

Treatment of duodenal ulcer.

Treatment of stomach ulcers.

Prevent recurrence of stomach ulcers, duodenum .

Treatment of stomach and duodenal ulcer related to NSAID.

Preventing stomach and duodenal ulcers related to NSAID in risks.

Treatment of gastroesophageal reflux - esophagus.

Combined with appropriate antibiotics to treat stomach ulcer, duodenum caused by Helicobacter pylori.

Zollinger-Elision syndrome.

Children:

Children over 1 year and ≥ 10kg:

Treatment of esophageal reflux.

Combined with appropriate antibiotics to treat stomach ulcer, duodenum caused by Helicobacter pylori.

Pharmacology

Omeprazol is a benzimidazole that has attached groups, structured and similar to Pantoprazol, Lansoprazol, Esomeprazol.

Omeprazole inhibits the excretion of the acidic acid secretion due to inhibiting the enzyme system Hydro/Pot Omeprazol does not work on receptor (receptor) acetylcholine or histamine receptor. Take a single dose of 20 mg of omeprazole to create a strong and effective gastric secretion inhibitor. The maximum effect is achieved after 4 days of treatment. In patients with stomach ulcers, it is possible to maintain a 80% reduction in gastric acid in 24 hours.

Omeprazol can restrain Helicobacter pylori bacteria in patients with duodenal ulcer and/or reflux esophagitis infected with this bacteria. Combining omeprazol with some antibacterial drugs (for example, Clarithromycin, amoxicilin) can be exposed to H. Pylori accompanied by an ulcer and remission.

Pharmacokinetics

absorption

Omeprazol is destroyed in acidic environment.

omeprazol is completely absorbed in the small intestine after drinking for 3 to 6 hours. About 60%. Food does not affect the absorption of drugs in the intestine.

Distribution

The drug is attached to about 95% to plasma proteins.

Although omeprazol has a short -letting time in a short plasma, the drug has a long time (due to the prolonged attachment of the drug to H+/K+ ATPASE), so it can be used only once a day.

Metabolism

Omeprazol is almost completely metabolized in the liver, mainly thanks to the cytochrom P450 isoenzyme to become hydroxy omeprazol and a small part metabolized through CYP3A4 to form omeprazol sulfon.

Elimination

These substances are not active and eliminated mainly through urine, partly through stool.

The pharmacokinetics of the drug change is not significant in the elderly or the impaired renal function. In people with liver failure, the bioavailability of the drug tank and the clearance of the drug decreases, but there is no accumulation of drugs and metabolites of the drug in the body.

Before taking Omeprazol tablets TVP 20mg treat duodenal ulcer, stomach ulcer (3 blisters x 10 tablets)

How to use

omeprazol 20mg Used orally, drink in the morning, take the whole tablet with half a cup of water. Capsules are not chewed or crushed. For patients swallowing difficulties and for children, can take or swallow pills with liquid food.

Patients may open capsules and dissolve the powder in the follicle with half a cup of water or mix the powder in a liquid (such as a mild acidic juice or apple sauce, or a non -carbonated drink). Stir and drink immediately (or within 30 minutes) and always have to stir right before drinking and rinse with half a cup of water.

Dosage

adults:

Treatment of duodenal ulcer: Omeprazol 20 mg/day/day for 2 weeks. If the patient has not recovered, it can extend the treatment time for another 2 weeks.

Treatment of stomach ulcers: Omeprazol 20 mg/day/day for 4 weeks. If the patient has not recovered, it can extend the treatment time for another 4 weeks.

Prevention of duodenal and stomach ulcers: Omeprazol 20 mg/time/day. May be increased to 40 mg/day/day (if treatment fails).

To eradicate Helicobacter pylori in stomach - duodenal ulcer:

Omeprazol 20 mg + Clarithromycin 500 mg + amoxycilin 1000 mg: 2 times a week per week.

Omeprazol 20 mg + Clarithromycin 250 mg (or 500 mg) + Metronidazol 400 mg (or 500 mg or Tinidazol 500 mg): 3 times a week a week.

omeprazole 40 mg/day/day + [amoxycilin 500 mg + metronidazol 400 mg (or 500 mg or tinidazol 500): 3 times/day] oral for a week.

ulcerative treatment related to nonsteroidal anti -inflammatory drugs: Omeprazol oral 20 mg/time/day, for 4 weeks. If the patient has not recovered, it can extend the treatment time for another 4 weeks.

Preventing stomach and duodenal ulcer associated with nonsteroidal anti-inflammatory drugs in patients at risk (over 60 years old, a history of stomach-duodenal ulcer, a history of the above gastrointestinal bleeding): Omeprazol 20 mg/day/day.

Treatment of esophagitis due to gastroesophageal reflux - esophagus: Omeprazol 20 mg/ day/ day for 4 weeks. If the patient has not recovered, it can extend the treatment time for another 4 weeks. In patients with severe esophagitis can use omeprazol 40 mg/time/day for 8 weeks.

Treatment of Zollinger-Elision syndrome: The starting dose is 60 mg/day, the usual dose is effective 20-120 mg/day. If the dose is higher than 80 mg should be divided 2 times/day. Dosage and treatment time depending on clinical requirements.

Patients with liver failure: Dosage may need to be reduced, daily dose from 10-20 mg.

Patients with renal failure: No need to adjust the dose.

Elderly: No need to adjust the dose.

Children

Children (over 1 year old and weight 10-20 kg): Omeprazol dose 10 mg/time/day.

Children (over 2 years old and weight over 20kg): Omeprazol dose 20 mg/day/day.

esophageal reflux: treatment for 4-8 weeks. May be increased to 20 mg/day (if necessary).

Treatment of heartburn and acid reflux in stomach - esophagus: treatment for 4-8 weeks. May be increased to 20 mg/day (if necessary). If the disease is not controlled after treatment, it is necessary to reconsider the disease.

Children over 4 years old: Treatment of stomach and duodenal ulcer disease caused by Helicobacter pylori, recommended dose:

15 - 30 kg: Omeprazol 10 mg + clarithromycin 7.5 mg/kg body weight + amoxycllin 25 mg/kg body weight: 2 times a week per week.

31 - 40 kg: Omeprazol 20 mg + Clarithromycin 7.5 mg/kg body weight + amoxycilin 750 mg: 2 times a week per week.

Over 40 kg: Omeprazol 20 mg + Clarithromycin 500 mg + amoxycilin 1000 mg: 2 times a week per week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When overdose, only symptomatic treatment, no specific treatment.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Omeprazol TVP 20mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: headache, drowsiness, dizziness.

Digestive: diarrhea, nausea, vomiting, abdominal pain, constipation, bloating.

Uncommon, 1/1000

Neurological: insomnia, sensory disorders, fatigue.

Skin: urticaria, itching, rash.

Liver: Increase transaminase temporary.

Rare, ADR

Systemic: sweating, peripheral edema, hypersensitivity include: Evana, fever, anaphylaxis.

Hematology: leukopenia, thrombocytopenia, reducing all blood cells, peripheral, grain leukemia, autoimmune hemolytic anemia.

Neurological: Confusion has recovered, agitated, deep, hallucinations in elderly patients, especially in serious patients, hearing disorders.

Endocrine: big breasts in men.

Gastrointestinal: gastritis, candidiasis, dry mouth.

Liver: Hepatitis jaundice or no jaundice, cerebral disease - liver in people with liver failure.

Respiratory: bronchospasm.

muscle - bone: joint pain, muscle pain.

urinary: interstitial nephritis.

Proton pump inhibitors may increase gastrointestinal infections that inhibit gastric acid secretion.

Instructions on how to handle ADR

Must stop the drug when there is an unwanted effect.

Notify the doctor the side effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

omeprazol TVP 20mg contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Simultaneous use with Neltlnavir.

Be cautious when using

omeprazole can hide symptoms and slow down the diagnosis in patients with malignant damage in the stomach.

For the elderly, there is no need to adjust the dose.

In people with kidney failure, omeprazol's bioavailability changes negligible.

In people with liver failure, the area below seems to increase and the elimination of the drug slowed down; A dose of 20 mg per day is usually sufficient for these patients.

Using proton pump inhibitors may increase the risk of gastrointestinal infections (for example, Samonella infection, campylobacter).

Omeprazol used for prolonged use can increase the risk of infection, fracture especially in the elderly.

Use omeprazol for a long time can reduce blood magnesium, so it must be monitored in plasma magnesium concentrations when taking the drug.

Simultaneous use of Atazanavir with proton pump inhibitors reduces the level of Atazanavir in plasma, thus increasing the dose of Atazanazir to 400 mg and Ritonavir 100 mg (Omeprazol must not exceed 20 mg).

Omeprazol may reduce the absorption of vitamin B12 when long -term treatment.

omeprazol is a CYP2C19 inhibitor, when starting and ending treatment with omeprazole should consider the ability to interact with metabolic drugs via CYP2C19 (like clopidoprel).

Lupus erythematosus in the skin: Proton pump inhibitors are associated with semi -acute lupus lupus, if the lesions occur, especially in contact with light, accompanied by joint pain. Should notify the doctor and stop drinking omeprazol.

The ability to drive and operate machinery

The drug can cause dizziness, drowsiness so cautious when used in drivers and operating machinery.

Pregnancy

There is no data on the toxic effects of the drug on the fetus. Therefore, the use of omeprazol during pregnancy is only considered when really necessary.

Demonstrate period

Because the drug is distributed in breast milk, should consider stopping the drug or stop breastfeeding.

Interactive drug

omeprazol does not have clinical effects when used with food, alcohol, amoxicillin, bacampicilin, caffeine, lidocaine, quinidine or theophylin. The drug is also not affected by simultaneous use of metoclopramid.

omeprazol may increase the concentration of ciclosporin in the blood.

Omeprazol increases the effects of antibiotics in destroying Helicobacter pylori.

Omeprazol inhibits the metabolic of drugs metabolized by the liver's liver's cytochrom P450 enzyme system and can increase the concentration of diazepam, phenytoin, and blood warfarin. The metabolism of diazepam makes the effect of the drug longer. With a dose of 40 mg/day, omeprazole inhibits the metabolism of phenytoin and increases the blood levels in the blood, but the omeprazol dose of 20 mg/day has much weaker interaction.

omeprazol inhibits the metabolism of warfarin but has little change of bleeding time.

omeprazol increases Dicoumarol's anticoagulant effect.

omeprazol reduces nifedipine metabolism at least 20% and may increase the effect of nifedipine.

Clarithromycin inhibits omeprazol metabolism and makes omeprazol levels double.

Omeprazol is a reduction in the acid of the stomach, which affects (increase or decrease) of the absorption of drugs that the absorption depends on the stomach pH.

Simultaneous use of omeprazol with Atazanavir reduces the concentration of Atazanavir in plasma.

The interaction between clopidogrel and omeprazol will reduce contact with active metabolites.

Due to the sharing of Omeprazol and Tacrolimus may increase the concentration of Tacrolimus in the serum.

Omeprazol may reduce the absorption of vitamin B12 (cyanocobalamin) when long -term treatment.

Concomitance use Omeprazol with Posaconazole, Erlotinib, Ketoconazole and Itraconazole The absorption decreases, thus reducing the effect of those drugs.

Methotrexate: When used with proton pump inhibitors, the concentration of methotrexate can increase in some patients.

Storage

Store at room temperature (not more than 30 ° C).

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