Omsergy hard capsules 20mg Saga treat duodenal ulcer, reflux esophagitis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

indications

Omsergy drugs are indicated in the following cases:

Adults

Treatment of duodenal ulcer.

Prolonged reflux treatment management and Zollinger - Ellison syndrome.

Reduce heartburn symptoms in patients with gastroesophageal reflux disease (Gord) and short -term reduction of functional indigestion.

duodenum ulcer caused by Helicobacter pylori - positive as part of a thorough treatment program with appropriate antibiotics.

Treatment of anti -inflammatory drugs - Steroid (NSAID) - Stomach ulcer and/or duodenum.

Reduce the risk of developing stomach ulcers and/or duodenum and reducing the risk of recurrence of stomach and/or duodenum ulcers that have been healed earlier in patients treated with NSAID.

Children

Short -term treatment (up to 3 months) Escapes of serious reflux ulcer with previous drug treatment.

Pharmacokinatus

omeprazol is a stomach inhibitor inhibitor in the stomach (H+/K+ ATPASE). This drug inhibits both stimulating stomach acid secretion and the bottom of the wall, whether generated by acetylcholine, gastrin or histamine. Omeprazol has no double influence on the receptors of Acetylcholine, Histamine or Gastric.

Omeprazol belongs to the new generation inhibitors, the derivative of benzimidazol, the drug has no cholinergic resistance or H2's H2 receptor resistance, which inhibits the secretion of gastric acid by inhibiting the enzyme system H+/K+ ATPAS

Because this enzyme system is considered as an acid pump in the gastric mucosa, omeprazol is considered as a acidic inhibitor of the stomach, blocking the final step of acid production. This effect is related to the dose and leads to inhibition of both basic acid secretion and acid secretion when stimulated by any stimulating agent.

Dynamic pharmacokinetics

omeprazol oral form is well absorbed but with a variable level. The absorption of omeprazol takes place in the small intestine and is usually completed within 3 to 6 hours. Biological equivalent depends on the dose and pH and can reach 70% when repeated. Food does not affect the bioavailability of omeprazol.

Omeprazol is more than 95% with plasma proteins. The clearance from the circulation by the metabolism in the liver with the half -life of plasma is from 30 to 90 minutes.

Metabolism in the liver mainly occurs through isemzyme cytochrome P450 (CYP) CYP2C19. The inactive metabolites are mainly excreted in the urine (80%) while the remaining 20% are discharged through feces.

Before taking Omsergy hard capsules 20mg Saga treat duodenal ulcer, reflux esophagitis (10 blisters x 10 tablets)

How to use

oral medication.

Omsergy is recommended to drink in the morning and drink by swallowing the whole tablet with half a glass of liquid.

Do not chew or break capsules.

Dosage

Adults

duodenal ulcer: 20 mg once a day for 2 to 4 weeks.

Stomach ulcer and reflux esophagitis: 20 mg once a day for 4 to 8 weeks.

In patients with stomach ulcers and esophagitis ineffective with other treatment regimes: the dose of 40 mg once a day can be effective.

Cases of stomach - duodenal ulcer related to NSAID whether or not treated with NSAID: 20 mg once daily.

Preventing peptic ulcer related to NSAIDs and indigestion symptoms: 20 mg once daily.

Thick skin reflux - duodenum with symptoms: 20 mg daily.

Zollinger - Ellison syndrome: 60 mg daily.

Elderly

No dose reduction in older patients.

Unknown long -term safety of omergy in patients with renal impairment and liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Smart, confusing, sweating, redness, headache, weakness, nausea and fast heartbeat have been reported due to over -bureaucratic phenomenon with omeprazol. There is no detoxification characteristic for overdose with omeprazol.

Handling

Symptomatic and support treatment.

Because omeprazol is attached to the protein that cannot be separated, the overdose patients who are determined to consult the doctor.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using omsergy, you may experience unwanted effects (ADR).

diarrhea, headache, nausea; Stomach pain, vomiting. Serious allergic reactions (redness; urticaria; itchy; Difficulty breathing; chest tightness; urinating blood; bone pain; Change urine amount; chest pain; dark urine; tachycardia, slow or uneven; fever, chills, or sore throat; Red, swollen, swollen skin, or peeling skin; severe diarrhea; severe stomach pain or cramps; swelling of the hands, ankles or feet; bruising or abnormal bleeding; abnormal fatigue; visual changes; yellow eye or skin.

Instructions on how to handle ADR

Must stop the drug when there is an unwanted effect.

With minor adverse reactions, usually just stop the drug.

In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticosteroids ...).

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Omsergy drugs contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Not yet established safety in pregnant women and nursing women.

Be cautious when used

Reduce stomach acid due to any cause, including proton pump inhibitors, increasing the amount of normal stomach bacteria that exist in the digestive tract.

Treatment for drugs that reduce gastric acid can lead to a slight increase in the risk of digestive infections, such as Salmonella and Campylobacter.

This drug contains sucrose, so patients with rare genetic problems about fructose intolerance, Glucose absorption disorders - Galactose or the deficiency of sucrase - isomaltase should not be used.

Some chronic children may need long -term treatment although not recommended.

The ability to drive and operate machinery

There is no evidence of omsergy may affect the ability to drive or operate the patient's machines.

Pregnancy

Results from 3 pre -rescue epidemiology (obtained more than 1,000 results) showed that there was no omeprazol adverse reaction during pregnancy or to the health of the fetus/infant. Omeprazol can be used during pregnancy.

breastfeeding period

omeprazol is secreted through breast milk but may not affect children when using the right dose.

Drug interaction

omergy is transformed through the P450 cytochrome liver enzyme system, and this can affect the metabolism of the drugs that also transform through these enzymes when using these drugs simultaneously. The elimination of Diazepam, Warfarin and Phenytoin may last when omergy is used simultaneously.

Inr track and plasma phenytoin concentration are recommended and the reduction of the dose may be necessary when omergy is used simultaneously. There may be interactions between omergy and digoxin and an increase of 10% of Digoxin.

There may be interaction with other drugs that also metabolized through the cytochrome p450 enzyme system.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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