Onsmix Suspension Huons oral solution reduces stomach acid, heartburn (20 packs x 10ml)

is a local anesthetic, which has a stronger anesthetic and is longer than hydrochloride or lidocaine hydrochloride when used on the mucosa. Due to the adsorption properties of aluminum hydroxid gel, the local anesthetic effect is prolonged.

Intro -in Vitro tests show that Oxethazain has a effect of reducing spasms on smooth muscles. The effect of reducing spasm of oxethazain is because it is antagonistic to the effect of serotonin on plain muscle.

Dry aluminum Hydroxid gel:

Hydroxyd aluminum has the ability to increase gastric pH. Hydroxyd aluminum increases gastroenter pH slower than antacids of calcium and magnesium groups. The increase in gastric juice caused by antacids will inhibit the protid elimination effect of pepsin; This effect is very important in patients with stomach ulcers. If the diet is low in phosphate, aluminum antacids will reduce phosphate absorption and cause decreased phosphate in the blood and decrease in urine phosphate.

aluminum hydroxyd is often used in combination with antacids containing magnesi to reduce constipation. Aluminum Gel - Magnesi Hydroxyd oral with the dose of treatment is likely to neutralize 200 meq acid, use 6-8 times daily, healing peptic ulcer is equivalent to cimetidine.

Magnesi Hydroxyd:

Antacid contains magnesi are inorganic magnesium mageci compounds in the acid that releases anions that neutralize the stomach acid, or as a cushion for gastric juice, but does not affect the production of gastric juice. As a result, the stomach pH increases, reducing acid increasing symptoms. The drug also reduces the acidity in the esophagus and reduces the effects of pepsin enzymes. This effect is especially important in patients with digestive ulcers. The optimal pH of Pepsin activity is 1.5 - 2.5; Because antacids increase the stomach pH above 4, the protein resolution of pepsin is the lowest. Magnesi Antacid also has a laxative effect, so it is often used in combination with aluminum Antacid to reduce the constipation effect of Antacid aluminum.

pharmacokinetics

oxethazain:

After taking 20 mg of Oxethazain in 10 ml of Onsmix Suspension, the peak concentration of oxethazain in serum reaches about 20 ng/ml about 1 hour after drinking. Oxethazain is biological metabolism very quickly and strongly, so the half -selling time in the serum of the drug is short, only approximately 1 hour. Under 0.1% of oxathazain is detected in urine in the form of unchanged within 24 hours. The main metabolite of oxethazain is beta - hydroxy - mephantermin and beta - hydroxy - phented. The amount of mephentin and phentermin appears in serum does not make sense in terms of pharmacological and excretion through the urine of these two substances totaling a total of 24 hours is no more than 0.1% of the dose is taken.

Dry aluminum Hydroxyd gel:

aluminum hydroxyd slowly dissolves in the stomach and reacts with gastric hydrochloride acid to form aluminum chloride and water. About 17 - 30% of aluminum chloride forms absorbed and quickly excreted through the kidneys in people with normal renal function. In the small intestine, aluminum chloride quickly transformed into insoluble aluminum salt, less absorbent. Aluminum is found in antacids (except for aluminum phosphate) in combination with food phosphate into the formation of non -soluble phosphate aluminum and excreted in feces.

Magnesi Hydroxys:

Magnesi hydroxys reacts with hydrochloride acid to form magnesi chloride and water. About 15 - 30% of the Magnesi Chloride has just produced and then eliminated through urine in humans with normal kidney function. The remaining amount of Magnesi Hydroxyd has not been reacted to form Magnesi Chloride can be metabolized in the small intestine and is negligible.

Notice immediately to the doctor when encountering unwanted effects of the drug.

Be cautious when using

Be careful with people with congestive heart failure, edema, cirrhosis, low sodium diet and for new people with gastrointestinal bleeding.

Elderly, due to illness or medication may be constipated or solid feces. For patients with prolonged or chronic indigestion need to be carefully tested.

The use of antacids containing magnesi for patients with mild renal impairment is both needed to be carefully monitored because the drug increases the risk of increased blood magnesium.

For patients with chronic renal failure, the use of drugs can increase aluminum in the blood. The use of prolonged or large doses of acid -containing acid -containing acid drugs can cause patients with special blood phosphorus in patients with a diet that is not enough phosphorus. Must check the concentration of blood phosphorus once a month or two months for patients with chronic kidney failure using prolonged antacids.

The ability to drive and operate machinery

Because the drug has an unwanted effect that causes dizziness and drowsiness, should be cautious when driving and operating machinery.

Pregnancy

must not be used for pregnant women because of the safety of drugs in pregnant women who have not been studied.

The period of breastfeeding

is not used for breastfeeding women because of the safety of nursing women who have not been studied.

Medicinal interaction

Onsmix Suspension can reduce the speed as well as the level of absorption of many drugs. Therefore, do not take other medications before or after taking onsmix suspension one or two hours. These drugs include: Tetracyclin, iron salts, isoniazid, ethambutol, benzodiazepin, phenothiazin , ranitidin, indomethacin, phenytoin , nitrofurantoin, vitamin a , fluorid and phosphat salts.

If the urine is alkaline after taking antacids, it can lead to the risk of increasing the concentration of quinidine in the blood and leading to poisoning.