Opelomin 6 OPV tablet treatment for worms, e -worms (2 blisters x 2 tablets)

Dosage form Box of 2 blisters x 2 tablets
Specifications Ivermectin

Ingredient

Composition information	Content
Ivermectin	6mg

Uses

indications

opelomin 6 drugs are indicated in the following cases:

Onchocerca Volvulus.

ATC code: P02C F01

Ivermectin is a semi -synthetic derivative of one of Avermectin, a group of lacton structons large, isolated from the fermentation of streptomyces Avermitilis.

Ivermectin is effective on many round worms such as eelworms, hair worms, needle worms, roundworms, hookworms and worms Wuchereria bancrofti. Ivermectin selectively and has high affinity with chloride channels through the glutamat port that occurs in muscle and nervous cells in the vertebrates, resulting in an increase in the permeability of cell membranes for chloride ions with the high polarization of neuron or muscle cells, the result causes prize and kill parasitic animals.

Ivermectin is an onchocerca Volvulus larvae that has little effect on adult parasites.

Dynamic pharmacokinetics

After drinking, the peak concentration in plasma is achieved after 4 hours. The drug is concentrated in the liver, adipose tissue and is not easily passed through the bloody barrier. About 93% of the drug is associated with plasma proteins, mainly albumin. Ivermectin is metabolized in the liver, mainly thanks to CYP3A4. Ivermectin and its metabolites are excreted mainly in feces (in about 12 days), less than 1% are eliminated through urine. The sale time of ivermectin is about 18 hours.

Before taking Opelomin 6 OPV tablet treatment for worms, e -worms (2 blisters x 2 tablets)

How to use

oral medication.

Dosage

Worm treatment only:

Use a single dose of 0.15 mg/kg. Higher doses will increase the harmful reactions, without increasing the effectiveness of treatment. It is necessary to re -treat the same dose as above 3 - 12 months until there are no more symptoms.

Dosage recommendations based on body weight:

From 15 to 25 kg: 0.5 tablets.

From 26 to 44 kg: 1 tablet.

from 45 to 64 kg: 1.5 tablets.

from 65 to 84 kg: 2 capsules.

Over 85 kg: 150 mcg/kg.

Selemia treatment:

Recommended the use of a single dose of 0.2 mg/kg; Conducting stool tests. Other dose: 0.2 mg/kg/day, for 2 days.

Dosage recommendations based on body weight:

From 15 to 24 kg: 0.5 tablets.

from 25 to 35 kg: 1 tablet.

From 36 to 50 kg: 1.5 tablets.

From 51 to 65 kg: 2 capsules.

From 66 to 79 kg: 2.5 tablets.

Over 80 kg: 200 mcg/kg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Skin, edema, headache, dizziness, dizziness, weakness, nausea, vomiting, diarrhea. Other unwanted effects include seizures, ventricles, shortness of breath, abdominal pain, abdominal pain and urticaria.

How to handle

In case of poisoning, supporting treatment includes infusion and electrolytes, respiratory aids, and vasodilators if there is significant hypotension. Causes vomiting and/or gastric lavage as soon as possible. After that, use bleach and other anti -toxic measures if needed to prevent the absorption of more drugs into the body.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using opelomin 6, you may experience unwanted effects (ADR).

worm treatment only:

Common, ADR> 1/100

joints: joint pain/epidemic inflammation.

Lymph nodes: enlarged and lymph nodes in the armpits, neck and inguinally.

Skin: itching, skin reactions such as edema, nodules, pustules, skin rash, urticaria. body: Fever. Cardiovascular: Hypotenary blood pressure, tachycardia.

Uncommon, 1/1000

Central nerve: headache.

peripheral nerve: muscle pain.

Ecconworm treatment:

Common, ADR> 1/100

Digestive: diarrhea, nausea.

Neurology: Dizziness. Skin: itching.

IT, 1/1000

Body: weakness/fatigue, abdominal pain.

digestive: Anorexia, constipation, vomiting. nerve: drowsiness, dizziness, tremor. skin: rash, urticaria.

Instructions on how to handle ADR

Notice immediately to the doctor or pharmacist the harmful rules encountered when using the drug.

Warnings

contraindicated

opelomin 6 contraindications in the following cases:

Hypersensitivity to any ingredients of the drug.

Caution when using

does not have much experience using drugs for children under 5 years old, so do not take medicine for this age.

Rarely, patients infected with worms are only infected with severe speaker speakers that can develop serious brain disease or even cause death spontaneously or after treatment with a parasite killer, in these patients, the following adverse effects have been reported: pain (including neck pain and back pain), redness, conjunctival hemorrhage, shortness of breath, hard -to -control, hard -to -control Mixed, sleeping, stunned, convulsive, or coma. Very rarely this syndrome after using ivermectin, in people who ensure the treatment with Ivermectin for any reason and exposed in areas where Western or Central African speakers circulation, the evaluation before treatment and careful monitoring after treatment should be done.

Due to ivermectin that increases gaba, it is possible to act on the central nervous system in humans that the brain barrier is damaged (such as in meningitis, trypanosoma disease).

When treated with Ivermectin for patients with worm dermatitis only onchocerca can increase the reaction, may occur more harmful reactions, especially edema and make the disease worse.

Only use drugs for those who have been diagnosed with worms only mentioned above or suspected infection. Not used for prevention.

Children

Safety and efficiency on children weighing less than 15 kg is not determined.

Elderly

Be cautious when treating elderly patients.

The ability to drive and operate machinery

The drug is likely to cause dizziness, dizziness, so it is necessary to be cautious when driving and operating machinery.

Pregnancy

There are no adequate studies and good verification in pregnant women. Therefore, Ivermectin should not be used during pregnancy because of the unsafe safety.

Lactation period

Ivermectin secretes breast milk with low concentrations. Only treat mothers who are breastfeeding when the benefits for mothers are higher than the risk for breastfed babies.

Interactive drug

Theoretically, iVeMectin may increase the effects of GABA receptors stimulants (such as benzodiazepine and sodium valproat).

Ivermectin's bioavailability may increase due to alcohol, levamisol.

Ivermectin may increase the effects of vitamin K anti -vitamin drugs.

Ivermectin may be the substrate of the P-Glycoprotein transportation system. Theoretically interacting with touch substances (such as Amprenavir, Clotrimazol, Phenothiazin, Rifampin, Ritonavir, St. John’s Wort) or inhibitors (such as Amiodaron, Carvedilol, Clarithromycin, Cyclosporin, Erythromycin, iTraconazole, Ketoconol, quinide, quinide, quinide, quinide, quinide, quinide, quinide, quinide Ritonavir, Tamoxifen, Verapamil) of this transportation system. Simultaneous use with theoretical inhibitors can increase the concentration of Ivermectin in the brain and cause neurotoxicity.

Ivermectin reduces the effects of BCG (TB vaccine) and typhoid vaccine.

Storage

Store at temperatures below 30 ° C, in a dry place, avoid light.

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