Oral 5ml Eastern Supodatin solution provides vitamins and minerals (30 tubes)

Dosage form Syrup
Specifications Box of 30 tubes x 5ml
Ingredient Vitamin B12, iron, calcium, magnesium, lysine, vitamin A, vitamin B1, vitamin D3

Ingredient

Composition information	Content
Vitamin B12	50mcg
Iron	15mg
Calcium	12.5mg
Magnesium	4mg
Lysine	12.5mg
Vitamin A	2500iu
Vitamin B1
Vitamin D3	200iu

Uses

indications

Supodatin is indicated in the following cases:

Provide essential vitamins and minerals in cases of malnutrition, anorexia, rickets, growth slowly.

Vitamin D: refers to a group of sterol compounds with similar structure, preventive activity or treatment of rickets. These compounds include: ergocalciferol (vitamin D2), colecalciferol (vitamin D3; international common name: colecalciferol), alfacal-cidol (1 alfa-hydroxycholeciferol, Deletediol (25-hydroxycoleciferol), Calcitriol) (1 ALFA, 25-25-25- dihydroxycoleciferol) and dihydrotachysterol. These substances, in their activity form (1.25 - dihydro -xyergocalciferol, 1.25 - dihydroxycoleciferol and 25 - hydroxydihydrotachysterol) Vitamin D is maintaining a normal calcium and phosphorus concentration in plasma by increasing the effectiveness of absorption of substances from the diet, in the small intestine, and increasing the mobilization of calcium and phosphorus from the bone into the blood.

Vitamin B1 when entering the body turn into thiamin phosphate is the activity form of carbohydrate metabolic carbohydrate to remove carboxyl of alpha cetoacid such as pyruvat, alpha cetogutarat and in using pentose in the Hexose Monophosphate cycle. When vitamin B1 deficiency, the oxidation of alpha - cetoacids is affected, increasing the level of pyruvat, which helps to diagnose vitamin deficiency.

Vitamin B2 is involved in the metabolism of lipid, purin, amino acids. Vitamin B, also plays an important role in teaching many substances in the body.

Vitamin B3 when entering the body is converted into nicotinamid adenin dinucleotid (NAD), or Nicotinamid adenin Dinucleotid phosphate (NADP), NAD and NADP plays a role as a catalyst for oxidative and redox reactions essential for respiration in tissue, metabolism

Vitamin B6 when entering the body transforms into pyridoxal phosphate and partly into pyridoxamin phosphate. These two substances act as coenzymes in the metabolism of protein, glucid and lipid. Pyridoxin participates in the synthesis of gamma acid - Aminobutyric (GABA) in the central nervous system and participates in Hemoglobulin synthesis.

Vitamin B12 when entering the body forms active coenzymes, methylcobalamin and 5 - deoxyadenosylcobalamin is essential for copying and growth cells. Methyl -Cobalamin is needed to create methionine and the derivative of S - Adenosylmethionin from Homocystein. When vitamin Bız concentration is not enough, it will cause a decline in the function of some forms of folic acid needed in the cell. Vitamin B is essential for all tissues with strong cell growth such as hematuria, small intestine, and uterus. Vitamin B12 deficiency also causes neuromatic myelin.

iron is an essential component of the body needed for hemoglobin formation and the processes in living tissues need to fly. Using iron will help overcome abnormalities in the creation of red blood cells due to iron deficiency. Iron does not stimulate the creation of red blood cells without iron deficiency.

calcium:

absorption: Calcium is absorbed at the upper part of the small intestine. In healthy adults, the amount of absorption is about 1/3 of the amount of food. Dusk vitamin increases the absorption of calcium from the intestine while mobilizing calcium into the bone. Phytat and oxalate can create a complex or insoluble salt with calcium, making calcium not absorbed.

Distribution: The skeletal system contains 90% of the calcium in the body. The structural arrays of the bone are not only made up of calcium but also by many other inorganic salts including sodium, potassium, magnesi, carbonate and flour. In plasma, 40% of calcium in the form of protein, 10% dispersed and complexed with anions such as citrate and phosphate, the rest dispersed in the form of calcium ions.

Excretion: Calcium is excreted through the digestive system such as saliva, face and pancreatic juice to discharge through stool. Calcium is also significantly excreted through breast milk and sweat. Calcium is eliminated in urine and is associated with sodium excretion. Calcium is re -collected in the tube near the influence of PTH and in the distance below the influence of smoothie d.

Magnesi: Physiology, Magnesi is a cation in the intracellular. Magnesi reduces the stimulation of neuron and neuron - muscle transmission. Magnesi participates in many enamel reactions.

Lysin is an essential amino acid that one of its functions is an important role in creating bones. In children, Lysin is an amino acid that is often considered not to be provided.

Dynamic pharmacokinetics

vitamin A: After the enzymes of the pancreatic pancreatic hydrolyzate into retinol, the esters of vitamin A are absorbed in the digestive tract. Fat absorption, lack of protein, liver dysfunction or pancreatic function reduces the absorption of vitamin A. Some retinols are stored in the liver and thereby released into the blood in the form of a specific globulin. The body's vitamin A reserves often meet the body needs in a few months.

Free retinol parts are glucuronic and oxidized into retinal and retinoic acid and then excreted in urine and stools along with other metabolites.

The normal concentration of vitamin A in plasma is from 300 to 600 micrograms/it. In the case of vitamin A deficiency, low concentration ≤ 100 micrograms/IT, and in case of overdose or poisoning, this concentration is much higher.

Vitamin D: well absorbed through the gastrointestinal tract. Both vitamins D2 and D3 are absorbed from the small intestine. The exact part of the intestine absorbs many vitamin D depending on each field that Vitamin D is dissolved. The necessary side for absorption of vitamin D in the intestine. Because vitamin D is soluble in lipids, it is concentrated in microorganisms, and is absorbed in the lymphatic system; approximately 80% of vitamin D orally absorbed by this mechanism. Vitamin D and its metabolites rotate in the blood associated with specific alpha globulin. The half -life in the plasma of Vitamin D is 19-25 hours, but the drug is stored for a long time in fat tissue.

Vitamin D and its metabolites are excluded mainly through bile and feces, only a small amount appears in the urine. Some vitamin D can be secreted into milk.

Vitamin B1: The absorption of vitamin B, in daily eating through the gastrointestinal tract is due to the positive transportation of Na+. When vitamin B concentration, in the digestive tract, passive diffusion is also important. However, high -dose absorption is limited. When absorbing exceeds the minimum demand, the vitamin B storage, in the first tissue is saturated. The excess amount will then be eliminated through the urine in the form of vitamin B molecules, intact. When absorbing vitamin B, increasing further, eliminating in the form of unprocessed vitamin B1 will increase.

Vitamin B2: Vitamin B2 is absorbed mainly in the duodenum. The metabolites of Vitamin B, are distributed throughout the tissue in the body and into milk. A small amount is stored in the liver, spleen, kidney, heart.

Vitamin B3: Fast absorption through the gastrointestinal tract after drinking and widely distributed throughout the body. The half -life of the drug is about 45 minutes. Vitamin B, metabolized in the liver into N - methylnicotinamid, derivatives 2 - pyridon and 4 - pyridon, and also forming nicotinuric. After taking Vitamin B, with the usual dosage, only a small amount of excretion in the urine in the form of unchanged; However, when using large doses, the amount of excretion in the form of unchanged will increase.

Vitamin B6: Quickly absorb through the digestive tract, except for the case of poorly absorbed syndrome. After taken, the drug is mostly dedicated in the liver and part of the muscle and brain. Vitamin B6 excreted mainly through the kidneys in the form of metabolism. The amount of introduction, if exceeding the daily demand, most excreted in the form of unchanged.

After drinking, vitamin B, absorbed through the intestine, mainly in ileum in two mechanisms: Passive mechanism when used in large amounts; And the active mechanism, allowing the absorption of physiological doses, but it is necessary to have the intrinsic factor, glycoprotein, which is secreted by cells into the stomach mucosa.

iron is absorbed unprecedented and not entirely from the digestive system, the absorption position is mainly in the duodenum and the rosary. The absorption is supported by gastric acid secretion or acids in food and is easier to impact when iron in iron form II. The absorption also increases when there is a deficiency of iron or in diet conditions but decreases if the body's reserves are too redundant.

II II through the gastrointestinal mucosa goes straight into the bloodstream and immediately combined with the transferrin. Transferrin transports iron to the bone marrow to combine into hemoglobin.

Most iron is released due to the destruction of hemoglobin retained and reused by the body. The secretion of iron is mainly through the peeling of cells such as skin, digestive mucus, nails and hair; Only a very small amount of iron is excreted by the surface and sweat.

calcium: calcium is the element that largely lies in the bone. Using enough calcium is important in the developing bone period in children and puberty as well as during pregnancy and lactation. The supply of calcium is essential for adults, especially the age of 40 to prevent the lack of calcium balance, which can lead to osteoporosis.

Calcium salts play an important role in regulating the permeability of the film for sodium and potassium, the integrity of the mucosa, the adhesion of the cell. Increased calcium concentration decreases permeability and vice versa.

Magnesi: is the fourth most cation in the body and the second in the intracellular role in the role of physiological activity needed on the cardiovascular system, reducing the sensitivity of the vascular wall to the substance that causes vasoconstrictor, increasing coronary hemorrhage, enhancing heart muscle metabolism, association with K+ ions with the effect of digitalis. Magnesi is also an important element of more than 300 enzyme reactions related to energy metabolism, protein biosynthesis and nucleic acid.

Before taking Oral 5ml Eastern Supodatin solution provides vitamins and minerals (30 tubes)

How to use

oral medication.

Dosage

Take it once a day:

From 1 - 12 years old: 5 ml (1 tube).

over 12 years: 10 m (2 tubes).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In children the symptoms of chronic poisoning include increased intracranial pressure (stretching), eyelid edema, tinnitus, visual disorders, pain along the bones. Must stop taking drugs, symptomatic treatment and supportive treatment.

After taking the drug in very high doses can lead to poisoning due to vitamin D. Daily use for a long time in large amounts (equivalent to 50 ml) can cause symptoms of chronic poisoning such as vomiting, headache, drowsiness and diarrhea. Acute properties are only seen at higher doses.

Should notify patients about the dangers and symptoms of vitamin D overdose leading to vitamin D and serum calci poisoning due to vitamin D as in ADR.

Treatment of vitamin D toxicity: Stop the drug, stop supplementing with calcium, maintain a diet with low calcium, drink plenty of water or infusion. If necessary, corticosteroids can be used or other drugs, especially diuretics increase calcium (such as: Furosemid and ethacrynic acid), to reduce carcinomic concentration in serum. Có thể sử dụng lọc máu thận nhân tạo hoặc thẩm tách màng bụng để thải calci tự do ra khỏi cơ thể. If vitamin D poisoning is acute, just taken, it can be prevented to continue absorbing vitamin D by causing vomiting or gastric lavage. If the drug is over the stomach, oil treatment can promote vitamin D elimination through feces. Because the 25 - OH metabolites of ergocalciferol and colecalciferol are accumulated in the body, hypercalcemia may last for 2 months or longer, after long -term treatment with large doses of these drugs. After stopping treatment with dihydrotachysterol or calcifediol, hypercalcemia still exists in the corresponding range of 2 or 2-4 weeks. After stopping treatment with calcitriol, the serum calcium concentration returns to normal within 2-7 days.

Vitamin B3: When an overdose occurs, there is no specific detoxification measure. Use common measures such as vomiting, gastric lavage, symptomatic treatment and support.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Supodatin, you may experience unwanted effects (ADR) such as:

There is no side effects when used according to the recommended dose.

Side effects and effects will appear when taking high doses for a long time or when taking very high doses of vitamin A. The typical symptoms are: fatigue, irritability, anorexia, weight loss, vomiting, digestive disorders, fever, changing skin, hair loss, dry hair, chapped lips and bleeding, anemia, headache. In children the symptoms of chronic poisoning include increased intracranial pressure (stretching), eye -eyed edema, tinnitus, visual disorders, pain along the bones.

Hypercalcemia and vitamin D toxicity.

Vitamin B1:

The harmful reactions of B vitamin, very rare and are often allergic.

Rare, ADR

Systemic body: Sweating, hypersensitivity

There is no unwanted effect when using vitamin B2. Using high doses of Vitamin B, the urine will turn light yellow, causing deviations for urine tests in the laboratory.

Vitamin B3:

Small dose of vitamin B, usually non -toxic, but if high doses may occur the following effects, these side effects will go away after stopping the drug.

Digestive: Nausea.

Dosage of 200 mg/day and a long day (over 2 months) can cause severe peripheral neuropathy, progressing from unstable gait and numbness to numbness and clumsy hands. This condition can recover when stopping the drug, although it still leaves more or less sequelae. Rare: Nausea, vomiting.

Vitamin B12:

Rare, ADR

Body: Anaphylaxis, fever. In very few cases, it can be seen.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Supodatin drugs contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug. Excess vitamin A, hypercalcemia, Vitamin D toxicity, severe liver disease, progressive stomach ulcers, malignant tumors, allergic atopic (asthma, eczema), iron infection, hemosi-thrin infection, hemolytic anemia, esophageal stenosis, bags and gastrointestinal tract, severe hypotension.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Vitamin A: Be careful when using other drugs containing vitamin A.

Vitamin D: sarcoidosis or parathyroidism (can cause increased sensitivity to vitamin D); renal function; heart disease; Kidney stones; atherosclerosis.

Vitamin B2: Vitamin deficiency, often occurs without other B vitamins.

Vitamin B6: Taking a dose of 200 mg daily, lasting over 30 days, which can cause vitamin B6 dependence syndrome.

Vitamin B3: Be careful when vitamin B, high doses in the following cases: History of stomach ulcer, gallbladder disease, history of jaundice or liver disease, gout, gout arthritis, and diabetes.

Iron: Caution should be cautious for patients with suspected stomach ulcers, anise inflammation or chronic colon ulcer. Do not take medicine when lying. Do not use iron to treat hemolytic anemia, except for the case of iron deficiency. Do not use the treatment for more than 6 months without the physician's monitoring. Do not use iron injected in combination with oral iron to avoid excess iron. Do not use medication for patients who are frequently transferred, because in hemoglobin of red blood cells contains a significant amount of iron.

The effect of the drug on driving and operating machinery

No report.

Use drugs for women during pregnancy and lactation

pregnancy:

Pregnant women must not use more than 5,000 IU of vitamin A per day.

If you use vitamin D at a larger dosage than the recommended daily daily doses (RDA) for normal pregnant people (400 dm), the risk may occur, so it should not be used for vitamin D at a larger doses than RDA for pregnant women. Aortic valve stenosis has occurred, kidney disease and mental retardation and/or developmental retardation when there is prolonged hypercalcemia in young children and babies that their mother has hypercalcemia during pregnancy. Hypercalcemia during pregnancy can reduce the concentration of parathyroid hormones in newborns leading to blood calcium, convulsions, and epilepsy.

If the diet is not enough vitamin D or lack of exposure to ultraviolet radiation, vitamin D should be supplemented to the dose of RDA during pregnancy

Vitamin B1: There is no risk known. The diet needed for pregnant people is 1.5 mg of vitamin B1. Vitamin B1 is actively transported into the fetus. Like other B vitamins, vitamin B1 concentration in fetus and newborn is higher in the mother. One study found that fetuses with alcoholic syndrome (due to alcoholic mother) developed very slowly in the uterus was due to vitamin B1 deficiency caused by alcohol.

Vitamin B2: Additional dose according to daily needs does not cause harmful effects on the fetus.

Vitamin B3: Using Vitamin B, with a dosage of diet for pregnant people does not cause harm to the mother and fetus.

Vitamin B6: Supplementary dose according to daily needs is not harmful to the fetus, but with high doses that can cause drug dependence syndrome in infants.

iron: iron (II) sulfate is used for pregnant people when anemia due to iron deficiency and folic acid.

breastfeeding period:

Vitamin D secretes milk, so it is not advisable to use vitamin D at a larger dosage than RDA for nursing mothers. Vitamin D should be added, if the diet is not enough vitamin D or lack of exposure to ultraviolet radiation.

Vitamin B1:

Mothers use vitamin B1 to continue breastfeeding.

Daily diet of vitamin B1 during breastfeeding is 1.6 mg. If the diet of nursing mothers is fully provided, there is no need to add vitamin B1: Just supplement vitamin B1 if the daily diet is not enough.

Vitamin B2: No effect when the mother uses on daily needs or low doses of vitamins.

Vitamin B3: Using vitamin B3 with the dosage of the diet of nursing mothers does not cause any harm to the mother and breastfed babies. It is necessary to use vitamin B3 with the dosage of diets of breastfeeding when the diet is not enough vitamin B3.

Vitamin B6: No effect when used according to daily needs. High doses of pyridoxin has been used (600 mg/day, divided 3 times) to turn off milk, although it is usually ineffective.

iron: Used for breastfeeding.

Interactive drug

vitamin A:

neomycin, cholestyramin, loose paraffin reduces vitamin A absorption.

Oral contraceptives may increase vitamin A concentration in plasma and have an unfavorable effect on conception. This explains why sometimes the possibility of conception is reduced in time right after stopping the use of steroids.

Vitamin A and Isotretinoin simultaneously can lead to an overdose of vitamin A. It is necessary to avoid using the two above drugs such as avoiding high doses of vitamin A.

Vitamin D:

Do not treat vitamin D simultaneously with choles-tyramin or colestipol hydrochloride, as it can lead to reduced absorption of vitamin D in the intestine.

Excessive use of mineral oil can hinder the absorption of vitamin D in the intestine.

Simultaneous treatment of vitamin D with diuretic gums for people with parathyroidism can lead to hypercalcemia. In that case, it is necessary to reduce the dosage of vitamin D or stop taking vitamin D temporarily. Using thiazid diuretics in those who are parathyroidism causing hypercalcemia is probably due to bone release from bone release.

Do not simultaneously use vitamin D with pheno -barbital and/or phenytoin (and maybe with other drugs that cause liver enzymes) because these drugs can reduce concentration 25 - hydroxyergocalciferol and 25 - hydroxy - colecalciferol in plasma and increase vitamin D into non -active substances.

Do not simultaneously use vitamin D with corticos-testoid because corticosteroids hinder the effects of vitamin D.

Do not simultaneously use vitamin D with support glycosides because of the toxicity of glycosides aids increased due to hypercalcemia, leading to arrhythmia.

vitamin B2:

Meet a number of "lack of riboflavin" in people who used clepopromazin, imipramin, amitriptylin and adriamycin.

Wine can hinder the absorption of riboflavin in the intestine.

Probenecid used with riboflavin causes reduced absorption of riboflavin in the stomach, intestines.

vitamin B3:

Simultaneously used with HGM - CoA reducing enzyme inhibitors may be an increase in the risk of pattern (thabdomyolysis).

Use vitamin B3 simultaneously with alpha - adrenergic blockers that treat hypertension can lead to excessive hypotension.

Using vitamin B3 simultaneously with toxic drugs with the liver can add toxic effects on the liver.

Diet and/or dosage of hypoglycemic or insulin or insulin may need to be adjusted when used simultaneously with vitamin B3.

Not simultaneously use vitamin B3 with carbama-zepin because of increased plasma carbamazepine levels leading to toxicity.

Vitamin B6:

Vitamin B6 reduces the effects of Levodopa in the treatment of Parkinson's disease; This does not happen with the preparation is a mixture of Levodopa - Carbidopa or Levodopa - Benserazid.

Dosage 200 mg/day may cause a decrease in 40-50% of the concentration of phenytoin and phenobarbiton in the blood in some patients.

Vitamin B6 can lighten depression in women who take birth control pills.

Oral contraceptives can increase the demand for vitamin B6.

Close: Avoid using iron combination with ofloxacin, ciprofloxacin, norfloxacin.

Take taken simultaneously with antacids such as calcium carbonate, sodium carbonate and magnesium trisilicate, or with tea water that can reduce iron absorption.

iron can chelate with tetracyclin and reduce the absorption of both drugs. Iron can reduce the absorption of penicilamin, carbidopa/levodopa, methyldopa, quinolones, thyroid hormones and zinc salts.

Magnesi:

Avoid using magnesium in combination with preparations containing phosphate and calcium salts are inhibitors of magnesium absorption process at the small intestine.

In case of treatment in combination with oral tetracyclin, two drugs must be taken at least 3 hours away.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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