Oral CaveNid 200 Pharbaco treatments for respiratory infections, skin infections (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefditoren
Ingredient Central Pharmaceutical Joint Stock Company I - Pharbaco

Ingredient

Composition information	Content
Cefditoren	200mg

Uses

Indications

Caveivivical 200mg drug indicated in the following cases:

Treatment of respiratory infections, skin infections and subcutaneous organization caused by gram -negative bacteria, sensitive grams, staphylococcus aureus strains (including β - lactamase secretions), Staphylococcus pyogenes sensitive.

Treatment of sore throat and tonsillitis caused by streptococcus pyogenes strains (hemolytic strikes β group A) sensitive. Although Cefditoren has the effect of destroying Streptococcus Pyogenes in the nose and throat, the effects of the drug in rheumatism are still being considered.

Exacection treatment of chronic and medium -sized chronic bronchitis caused by Haemaphilus Influenzae strains (including strains with β - lactamase), Haemophilus parainfluenzae (including strains with β - lactamase), Streptococcus pneumoniae (only with peniciline sensitivity), Moraxella Catnrhalis (including strains with β - lactamase).

Treatment of cases of pneumonia is caused by the haemophilus influenzae strains (including β - lactamase secretions), Haemophilus parainfluenzae (including β - lactamase), Streptococcus pneumoniae (only sensitive to Penicilin), Moraxella Cataxella (Moraxella Including strains with β - lactamase).

Pharmacokology

Cefditoren Pivoxil is a semi -synthetic antibiotic of the 3rd generation cephalosporin group used by oral treatment in the treatment of acute bacterial infections or acute batches of chronic bronchitis, infected pneumonia in the community caused by sensitive bacteria, including:

Haemophilus Influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae sensitive to penicilin, moraxella catarrhalis, sore throat (streptococcus pyogenes), skin infections and non -complications (staphylococcus aureus aureus pyogenes).

Cefditoren is sustainable with many types of beta - lactamase (including penicillinase and some cephalosporinase) produced by gram -negative and gram -positive bacteria. Similar to the current 3rd generation cephalospherin (Cefdinir, Cefixim, Ceftibuten, Cefpodoxim) Cefditoren has a wider Gram -negative bacteria than Cephalosporin, the first and second generation.

Moreover, cefditoren acts better with Gram -positive bacteria than other 3rd generation cephalosporins because of the cefditoren structure with methylthiazoleyl group, while other third -generation cephalosporins are not available.

The mechanism of action of Cefditoren Pivoxil is similar to antibiotics of the 3rd generation cephalosporin group. Cefditoren Pivoxil is a pre -pharmaceutical (Prodrug) with very little antibacterial effects.

Cefditoren Pivoxil is absorbed by the gastrointestinal tract and is hydrolyzed by esters to release the cefditoren that is active and pivalate into the bloodstream. Cefditoren has the effect of inhibiting the synthesis of bacterial cell walls by attaching one or more penicillin -binding -binding proteins - Pbps) to inhibit the final step of transferring amino acids between peptidoglycan synthesis chains in bacterial cell walls, due to inhibition of biometical bio -bacterial cells.

Dynamic pharmacy

cefditoren pivoxil is absorbed by the gastrointestinal tract and hydrolyzed by esterase into cefditoren with activity and pivalat into the bloodstream. When taken at hungry at the dose of 200mg Cefditoren, the highest concentration achieved in plasma is about 1.8 ± 0.6 µg/ml after taking 1.5 to 3 hours. Born when drinking at hunger is about 14% and increases if taken with a fatty meal.

The ratio attached to the plasma protein of cefditoren is 88%. Distribution volume 9.3 ± 1.6 liters.

Cefditoren is not much metabolized and excreted in the urine in the form of unchanged in the glomerular filter and excreted in the renal tubules. The drug can be eliminated by dialysis outside the kidney. Half of the lifetime elimination of the drug is about 1.6 hours and lasts longer in patients with renal function.

Pivalat is formed by the hydrolytic process of cefditoren pivoxil will combine with carnitin in the blood to form a pigalolcarnitin and excreted in the urine.

Before taking Oral CaveNid 200 Pharbaco treatments for respiratory infections, skin infections (2 blisters x 10 tablets)

How to use

oral drugs. Take medicine with meals to increase the absorption of drugs into the blood.

Dosage

Adults and children over 12 years old

Sore throat, tonsillitis: take 1 tablet/time, 2 times a day in 10 days.

Skin infection and subcutaneous organization: take 1 tablet/time, 2 times a day in 10 days.

Exacerbats of chronic bronchitis: Take the dose of 2 capsules/time, 2 times a day in 10 days.

Cases of pneumonia is suffering from the community: Take the dose of 2 capsules/time, 2 times a day in 14 days.

Patients with renal failure

No need to adjust the dose if patients with mild renal impairment (ClCR 50 - 80 ml/min/1.73m2), recommend only 200mm/time, 2 times/day for patients with medium renal impairment (CLCR 30 - 49 ml/min/1.73m2) and 200mg/time, 1 time/day for patients with severe renal impairment (CLCR Patients with end -stage renal failure have not yet been determined.

Patients with liver failure

It is recommended that there is no need to adjust the dose in patients with mild and medium -sized liver failure. There is no information on pharmacokinetics of cefditoren in patients with severe liver failure.

Old people

There is no special recommendation about the dose if the patient has a normal renal function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Symptoms of antibiotic dose β - lactam include: nausea, vomiting, epigastric pain, diarrhea and convulsions.

Blood fluid can be assisted in removing cefditoren from the body, especially if the kidney function is damaged (30% decrease in plasma concentrations after 4 hours of hemorrhage). Treatment of overdose and use of supportive measures if necessary.

Studies on animal toxicity toxicity, using Cefditoren Pivoxil with a limited dose of 5,100mg/kg in mice and 2,000mg/kg in dogs do not see health effects. Observed some certain symptoms such as diarrhea and soft stools lasting for a few days on a few animals, like the usual side effects of most antibiotics due to inhibition of intestinal bacteria.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Like all other drugs, Caveivivation may have some side effects, although not happening to everyone.

Very common side effects (ADR ≥ 1/10 people):

diarrhea (11 - 15%).

Central nervous system: headache (2 - 3%). hematocrit (2%).

Acute renal failure, allergies, joint pain, bronchial asthma, hyperplasia, hematuria, blood calcium, increased blood clotting time, pink rash fixed in chromosomes, fungal infections, hyperlemia, interstitial pneumonia, leukopenia, hyperkalemia, hypoglyc sodium, fake colitis, Stevens - Johnson syndrome, Hemorrhagic reduction of threlon, toxic skin.

Instructions on how to handle ADR

The method of handling some ADR is as follows:

If there is a fake colitis or diarrhea caused by Clostridium difficile, it is often necessary to stop antibiotics. There are cases where just stopping antibiotics is all symptoms. Cases of medium and severe diarrhea need to be infused, electrolytes, protein supplements, antibiotics that work with Clostridium difficile (such as oral metronidazol or vancomycin). In case of need for colon surgery.

If there is hypersensitivity due to cefditoren, Cefditoren is needed and appropriate symptom treatment.

Prothrombin's effects can occur with risky subjects (patients with renal impairment, liver failure, poor nutrition, prolonged antibiotic use, long -term treatment with anticoagulant drugs), these cases must monitor blood coagulation time and vitamin K supplement.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CaveIVI drug is contraindicated in the following cases:

Hypersensitivity to cefditoren, other cephalosporins and any ingredients of the drug. Do not recommend used for children under 12 years old.

Precautions when used

Antibiotic treatment including Cefditoren can imbalance the microbiological system in the colon, making Clostridium difficile overexplicable. Clostridium difficile diarrhea and fake colitis may be at a level from mild to critical. The toxins secreted by Clostridium difficile increases the incidence of the disease and the mortality rate due to antibiotic resistance and must be removed. Need to monitor this expression during treatment.

Need to monitor and detect hypersensitivity expressions when using Cefditoren. Precautions when used for patients with a history of hypersensitivity to penicillin (especially cases of hypersensitivity manifested through IgE intermediaries such as anaphylaxis, urticaria), poor eating patients or those who are being nourished in the intestinal tract and poor health patients (patients need to be carefully monitored due to the possibility of vitamin K loss).

Be cautious when used for patients with a history of convulsions, if in the case of kidney failure, the risk of convulsions increases.

Use cautiously for cases of liver failure, kidney failure, dose adjustment if patients with severe renal impairment.

For people with camitin deficiency, do not use prolonged cefditoren due to cefditoren causing carnitin elimination.

Because cefditoren can cause prothrombin prolonged time, so need to be cautious when used in patients with bleeding disorders.

According to the general principle, to prevent the appearance of anti -drug microorganisms, after determining the sensitivity of microorganisms to the drug, the time to use the drug should be limited to the minimum time needed to treat the patient's condition.

Children

Not used for children under 12 years old.

Older people

The rate of side effects in the elderly is no different from adults. However, the elderly often has a decrease in physiological function, so it is necessary to use the drug carefully.

Note two points: Dosage and distance between doses should be adjusted according to the patient's condition.

The elimination of drugs is prolonged in patients with renal impairment. Therefore, high serum medication can last for the elderly.

Like other similar drugs, there has been a report on the risk of bleeding due to vitamin K deficiency in the elderly.

Pearlitol 160C (mannitol): The ingredient of mannitol in the drug can cause light laxative.

Using drugs for women during pregnancy and lactation

Pregnant women

Animal research does not see adverse reactions to the fetus. The safety of the drug for pregnant women has not been announced. In addition, decreased plasma camitins in women who use antibiotics containing pivoxil groups in the last three months of pregnancy have been reported, as well as in newborn babies of these mothers. Only use this drug for pregnant women or intend to get pregnant when the benefits of taking the drug beyond the risk may occur during treatment.

breastfeeding women

The drug is distributed into breast milk, so use carefully with nursing women.

The effect of the drug on driving, operating machinery

The drug does not affect the ability to drive or operate machinery.

Drug interaction

need to tell your doctor or pharmacist other drugs that are using or used recently, including non -prescribing drugs.

antacids

Simultaneously use a single dose of antacids containing both magnesi (800mg) and aluminum (900mg) hydroxide reduces the absorption of the only dose of 400mg cefditor taken after meals.

Increase toxic effects

Probenecid increases the plasma cefditoren levels thus increasing the effect/toxicity of cefditoren.

Reducing effects

Proton pump inhibitors and H2 receptor antagonistic drugs reduce Cefditoren absorption, thus reducing the effect/toxicity of cefditoren.

Food interaction

Food increases the absorption of cefditoren. Fatty meals can increase the maximum of the drug.

Testing interactions: can cause direct positive coombs reaction, fake negative ferricyanid test, pseudo -positive glucose test when using clinitest.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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