Oral powder Abamotic 5mg Oriental treatment of gastrointestinal symptoms, gastritis (30 packs x 0.5g)

Dosage form 30 package box
Specifications Mosaprid citrate
Ingredient Orient Pharmaceutical & Trading Company

Ingredient

Composition information	Content
Mosaprid citrate	5mg

Uses

indications

Abamotic drugs are indicated in the following cases:

Pharmacokology

Pharmacological group: Gastrointestinal drug group.

ATC code: A03FA.

Mosaprid Citrate has a selective effect on the 5-HT4 body, and has a counterbalance to the 5-HT3 receptor. Mosaprid Citrate stimulates 5 -HT4 receptors in digestive nerve plexus, increasing acetylcholin release, leading to enhancement of stomach - intestinal movement and gastric emptiness.

Dynamic pharmacokinetics

The average plasma concentration of mosaprid citrate does not change when used oral at 10 mg/kg of weight in both male and female dogs, and reaches the maximum concentration after 0.5 hours of giving the drug. The maximum concentration in male dogs is 198 ng/ml and the female dog is 289 ng/ml. After that, this concentration quickly dropped. The sale time of the drug is 1.5 hours. After giving the dog Mosaprid Citrate 10 mg/kg of weight, the drug concentration in the tissue measured by radioactive is maximum after 1 hour. The concentration of drugs at tissue is 10 times higher than the plasma concentration, and higher than the concentration of the drug in the liver, small intestine, stomach, kidney, adrenal glands.

Mosaprid citrate concentration in the brain and low eyeball, only about ½ of plasma concentrations.

In a human study, the maximum concentration achieved after 0.8 ± 0.1 hours of giving the drug, after taking the single dosage mosaprid citrate 5 mg, the maximum concentration of the drug in plasma is 30.7 ± 2.7 (ng/mL). The sale time is 2.0 ± 0.2 hours. The ratio of plasma protein bonds is 99.0%. Mosaprid Citrate metabolizes mainly through the liver, with the main metabolic compound is Des-4-Fluoro-Benzyl.

Mosaprid Citrate is excreted mainly in urine and feces. In the urine sample obtained at 48 hours after taking a single dose of 5 mg Mosapid Citrate, 0.1% is excreted in the form of constant compound and 7.0% is excreted in the form of main metabolites (DES-4-Fluorobenzyl compound).

Before taking Oral powder Abamotic 5mg Oriental treatment of gastrointestinal symptoms, gastritis (30 packs x 0.5g)

How to use

oral medication.

Dosage

indicated in digestive symptoms related to chronic gastritis and gastroesophageal reflux:

How to use: Take before or after meals.

Dosage: 5 mg/time x 3 times/day.

Support for stomach cleansing before X-rays of gastrointestinal contrast with barium:

Take 20 mg of mosaprid citrate in about 180 ml of water to wash the digestive tract, then drink 20 ml of mosaprid citrate with a little water.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Do not overdose recommended.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Abamotic drugs may experience unwanted effects (ADR) such as:

In clinical trials, side effects are recorded in 40 of 998 cases (4.0%). Các phản ứng phụ chủ yếu là tiêu chảy, phân lỏng (1,8%), khô miệng (0,5%), khó ở (0,3%),... Các trị số xét nghiệm cận lâm sàng bất thường được nhận thấy ở 30 trên 792 trường hợp (3,8%), chủ yếu là tăng bạch cầu ái toan (1,1%), tăng triglycerid (1,0%), AST (GOT), ALT (GPT), ALP và gamma-GTP (mỗi loại 0.4%).

Other side effects:

Hypersensitivity: edema, rash, urticaria

Hematology: Nothing, leukopenia. bilirubin.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

ABAMOTIC medicine is contraindicated in the following cases:

Patients with a history of hypersensitivity to Mosap-Ride or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

When using this drug to treat digestive symptoms associated with chronic gastritis, it is necessary to assess the improvement of symptoms after use (usually 2 weeks). If there is no improvement after evaluation, it should be stopped.

Acute hepatitis, severe liver dysfunction, jaundice may occur during the use of the drug, so it does not use the drug for a long time. During treatment, patients should be closely monitored, if there are abnormal symptoms such as fatigue, anorexia, abnormalities in urine, yellow eyes, stop using the drug immediately and have appropriate treatments.

Used in the elderly: Because the physiological function of the kidneys and liver is often impaired in elderly patients, it is necessary to be careful when taking the drug by monitoring the patient's condition. If there is any side effect, it is advisable to apply appropriate measures such as reducing the dose.

Use in children: The safety of the drug in children has not been proven.

The effect of the drug on the ability to drive and operate machinery

Some side effects of the drug may occur such as dizziness, headache, so it is necessary to be cautious when using mosaprid citrate when driving and operating machinery.

Use drugs for women during pregnancy and lactation

do not have enough documents to prove the safety when using mosaprid citrate for pregnant and lactating women, so only use drugs when really necessary and need to consider risk benefits before using the drug.

In nursing women, if it is necessary to use the drug, it is necessary to stop breastfeeding during treatment with mosaprid citrate.

Drug interaction

When sharing erythromycin dose of 1200 mg/day with mosaprid at a dose of 15 mg/day, compared to when taking alone mosaprid, the peak concentration of mosaprid in the blood increases from 42.1 ng/ml to 65.7 ng/mL, the semi-cancellation period lasts from 1.6 hours to 2.4 hours and AUC0-4, increasing from 62 ng. NG.

Mosaprid reduces the effects of anti-cholinergic drugs-Atropin Sulfate and Butyl-SCO-Polamin Bromid.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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