Oral solution A.T Calcium cort An Thien supplement vitamins and minerals for the body (30 tubes x 10ml)

Calcium is an important cell ion, chemotherapy 2. Normal adults have about 1,300 g of calcium (male) and 1,000 g of calcium (female), 99% in the bone in the form of hydroxyapatite, the rest is present in foreign fluids, and a very small number in cells. In human plasma, calcium concentration is about 8.5 mg to 10.4 mg/dl (2.1 - 2.6 mmol) of which about 45% are attached to plasma proteins, mainly albumin and about 10% complex with anionic buffer (such as citrate and phosphate). The rest is calcification (Ca2+), Ca2+ is essential for many biological processes; Neuron stimulating neuron, releasing neurotransmitter, muscle contraction, preserving membrane and coagulating. Ca also helps the secondary communication function for the activity of many hormones.

On the heart: Calcium ions are essential for stimulating and contraction of the heart muscle as well as for electrical impulses on some areas of the heart muscle, especially through the atrium node. On the muscular nervous system: Calcium ions play an important role in stimulation and muscle contraction. Calcium is also the main component of the bone and is an essential component for the newly established bone calcification. The amount of calcium consumed in children is growing, pregnant and lactating people should be strengthened.

Ascorbic acid is important for collagen synthesis and intercourse components such as connective tissue, money tissue, dentin. This is a powerful reducing agent. Ascorbic acid protects the enzyme folic acid Reductase is an enzyme that converts folic into folinic and also participates in the release of free folic acid from food and promotes iron absorption. Ascorbic acid deficiency often occurs in children, alcoholics or the elderly.

In Nicotinamide body performs function after converting to Nicotinamide Adenine Dinucleotide (NAD) or Nicotinamide Adenine Dinucleotide phosphate (NADP), NAD and NADP plays a survival role in metabolism, as a coenzyme that catalyzes oxidation reactions - Essential for rheumatomically for cellular respiration, Glycogen, and Lipid. In these reactions, this coenzyme acts like hydrogen transport molecules.

pharmacokinetics

calcium is absorbed mainly in the small intestine through active transportation or passive diffusion. About 30% of calcium absorption and calcium absorption vary depending on the factors of the diet or state of the small intestine, as well as when a low -calcium diet will lead to increased absorption in children's period, pregnancy and lactation and partly due to the effects of vitamin D. excess calcium is excreted mainly through the kidney. Calcium does not absorb excreted through stool, along with secretion through bile and pancreatic fluid. A small amount lost through sweat, skin, hair and nails. Calcium through the placenta and distributed through breast milk. 98% of calcium ions are reabsorbed again in the renal tubules. This reabsorption is strongly adjusted by parathyroid hormone PTH. Armor hormone regularly regulates blood calcium levels by acting on the renal tubules.

Ascorbic acid (vitamin C) is usually well absorbed and distributed to tissues with oral doses of less than 100 mg.

A combination of vitamin PP helps increase calcium absorption in the stomach - intestines.

Nicotinic acid and nicotinamide are quickly absorbed in the stomach - intestines and are widely distributed to tissues. Nicotinic acid is present in breast milk. The main conversion line is converted into n-methylnicotinamide and derivatives 2-pyridon and 4-pyridon.

Small amounts of nicotinic acid and nicotinamide are excreted in urine in the form of unchanged after treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Caution when used

for patients with mild calcium hypertension (> 300 mg or 7.5 mmol/24 hours) and lesions of the renal function mild or medium or medium or with a history of urinary tract, need to monitor calcium secretion in urine. If necessary, reduce calcium dose or stop treatment. Drinking plenty of water should be recommended for patients prone to urinary tract. The drug contains 100 mg of vitamin C (10 ml tube), not harmful when used in daily instructions. Caution should be prudent for patients with a history of stomach ulcers, gallbladder disease, history of jaundice or liver disease, gout, gout arthritis.

Use cautiously in cancer patients, glucose-6-phosphate dehydrogenase (G6PD), anemia, kidney stones, or sickle blood cells, or after coronary heater. Use cautiously in patients with antibiotics, anti -cancer substances, HIV treatment, barbiturate, estrogen, fluuphenazine, or iron supplements.

Autodity warning

The drug contains excipients sucrose, sucralose and sorbitol, patients with rare genetic disorders such as fructose intolerance, glucose-galactose absorption or enzyme deficiency sucrase-isomtase should not use this drug. It should be impatient in Tartrazine, Sodium Metabisulfite, which is at risk for allergic reactions.

The drug contains excipients Cremophor RH40 (Polyoxyl 40 Hydrogenated Castor Oil). There have been separate reports on anaphylactic reaction on animals and on users of injection products that contain Cremophor El (Polyethoxylated Castor Oil).

Not observed the same reaction when using oral Cremophor RH40. However, pay attention to monitor allergic reactions on patients after using this product, including skin reactions, shortness of breath, chest tightness, hypotension, angioedema.

The effect of the drug on driving and operating machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

No harm when taking doses according to usual daily needs. However, pregnant women should be provided with calcium by adequate diet. Use too many vitamins and calcium and substances that can be harmful to the mother or fetus. Vitamin C, Nicotinamide with dosage diets for pregnant women do not harm the mother and fetus.

breastfeeding women

No harm when used by daily dose.

Drug interaction

calcium glucaheptonate

calcium reduces some drugs such as fluoroquinolone, tetracycline so the drug must be taken at least other at least 3 hours.

Corticosteroids reduce calcium absorption.

The drug can reduce the response of Verapamil and other calcium channel blockers.

Hypercalcemia when used in conjunction with thiazide diuretics.

ascorbic acid (vitamin C)

Simultaneous use of vitamin C with aspirin increases vitamin C secretion and reduces aspirin secretion in urine. Simultaneous use of Vitamin C and Fluphenazine leads to a decrease in plasma fluhenazine levels.

The acidification of urine after using vitamin C can change the excretion of other drugs.

Vitamin C is a powerful reducing agent, which affects many tests based on redox reactions. The presence of vitamin C in urine increases the fake glucose (or false negative results) if quantitative by the method of oxidase glucose.

Nicotinamide (vitamin PP)

The risk of muscle disease or muscle pattern may increase when taking nicotinamide with statin medications.

Nicotinamide can reduce glucose tolerance thus increases the need for insulin or oral hypoglycemic drugs.

Nicotinamide may increase plasma carbamazepine levels.

Cavalry: Due to no studies on the correlation of the drug, do not mix this drug with other drugs.