Oral solution A.T Desloratadin 2.5mg An Thien reduces allergic rhinitis, itching, chronic urticaria (30 packs x 5ml)

Dosage form Oral solution
Specifications 30 package box
Ingredient Desloratadine

Ingredient

Thành phần cho 5ml

Composition information	Content
Desloratadine	2.5mg

Uses

Indications

A.T desloratadin is indicated to reduce symptoms in diseases: allergic rhinitis, itching, chronic urticaria.

Pharmacokic

Desloratadine is a three -round antihistamine that has a long -lasting effect with H1 histamine resistance activity. The receptor base indicates that at a concentration of 2 - 3 ng/ml, the desloratadine has a significant interaction with H1 histamine receptor in humans.

On In vitro, desloratadine inhibits the release of cell histamine in humans.

Dynamic pharmacokinetics

Research results distributed by radio isotopes on the mouse indicating that desloratadine does not pass through the bloody barrier.

Oral

by oral, desloratadine 5 mg/time/day, taken within 10 days, average time to achieve the peak plasma concentration is approximately 3 hours after drinking. Fruit food and juice does not affect the bioavailability of desloratadine.

Desloratadine converts into 3 - hydroxydesloratadine, an active and later metabolites become glucuronidate. Enzymes ensure the formation of 3 -Hydroxydesloratadine has not been determined.

Desloratadine and 3 - Hydroxydesloratadine associated with plasma proteins approximately 82 - 87% and 85 - 89%. The cohesion of desloratadine and 3 - Hydroxydesloratadine does not change in patients with renal failure.

Desloratadine's semi -exhaust time is 27 hours. CMAX value (plasma peak concentration) and AUC (area under the curve) increased when using a single dose of 5 - 20 mg. Increased accumulation achieved after drinking 14 days suitable for the sale time and regular dose. Human research shows that about 87% of the desloratadine dose is found in urine and stool in the form of metabolites.

Studies on the skin of the human skin with a single dose and the repeated dose of 5 mg Desloratadine indicates that antihistamine inhibitors effectively after 1 hour and lasts 24 hours.

Before taking Oral solution A.T Desloratadin 2.5mg An Thien reduces allergic rhinitis, itching, chronic urticaria (30 packs x 5ml)

How to use

oral medication. Drink 1 time a day.

Dosage

for 5 ml tube specifications

Adults and children over 12 years: Take 2 tubes a day.

Children from 6 - 11 years old: Take 1 tube daily.

Children from 2 - 5 years old: Take 1/2 daily.

For packaging specifications

Adults and children over 12 years: Take 2 packs a day.

Children from 6 - 11 years old: Take 1 pack daily.

Children from 2 - 5 years old: Take 1/2 pack daily.

For bottle specifications

Adults and children over 12 years: Take 10 ml daily (measuring with the attached cup).

Children from 2 - 5 years old: Take 2.5 ml daily (measuring with attached cup).

People with severe liver or kidney failure (Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

Sleep, tachycardia, headache. In children there are expressions of the tower, brushing the chest.

How to deal with overdose drugs:

Desloratadine overdose treatment is usually symptomatic and supportive treatment. Causes vomiting with ipeca syrup, activated carbon. If vomiting is ineffective or contraindicated (patients with fainting, convulsions, lack of vomiting reflexes), the stomach can be carried out with 0.9% sodium chloride solution and intubation to prevent the inhalation of gastric juice.

Desloratadine is not eliminated by hemorrhage.

What to do when you forget 1 dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose and continue the schedule of A.T Desloratadin. Do not use double dose to compensate for missed dose.

Side Effects

When using A.T Desloratadin, you may experience unwanted effects (ADR).

Little side effects.

Desloratadine is well tolerated. Desloratadine causes some side effects such as headache, sleep, fatigue, dry mouth, shortness of breath, hangover, abdominal pain, discomfort, dizziness, hypersensitivity reaction.

In children: Usual side effects are diarrhea, fever, insomnia, headache.

Notice immediately to the doctor or pharmacist the harmful reactions when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

A.T Desloratadin is contraindicated in the following cases:

sensitive to desloratadin or other ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Be cautious with patients with liver failure.

Safe and effective when using desloratadin for children under 2 years old has not been determined.

When using desloratadin, there is a risk of dry mouth, especially in the elderly, and increasing the risk of tooth decay. Therefore, clean oral hygiene when using desloratadin.

Autodity warning: Patients with rare genetic disorders such as fructose intolerance, glucose-galactose absorption disorders or Sucrose-iomtase enzyme deficiency should not be used.

Methyl paraben, Propyl paraben can cause allergies.

Each 5 ml of solution contains 1 g of sucrose, 1 g of 70%sorbitol, 2.5 mg of sucralose, which should be considered when used for patients with diabetes. Each 5 ml of a solution contains 55 mg of propylene glycol, consult a doctor or pharmacist before children use the drug, especially when children are given other drugs containing propylene glycol or alcohol.

The ability to drive and operate machinery

In the treatment dose, the drug does not affect the ability to drive and operate machinery. However, note that headaches, fatigue, sleep, dizziness can occur during treatment.

Pregnancy

There are no complete studies and good tests for the use of desloratadine during pregnancy. Therefore only using desloratadine for pregnant and lactating women when necessary, with low doses and short time.

breastfeeding period

desloratadine and metabolites Descarboethoxyloratadine are secreted into breast milk. Therefore only using desloratadine for pregnant and lactating women when necessary, with low doses and short time.

Medicinal interaction

simultaneously used with ketoconazole, erythromycin or cimetidine, increased desloratadine concentration in plasma.

In tests: 48 hours should be stopped before conducting skin tests.

Drinking desloratadine with alcohol does not increase the risk of alcoholic behavior.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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