Oral solution A.T Desloratadin 2.5mg An Thien reduces allergic rhinitis, itching, chronic urticaria (60ml)

Dosage form Oral solution
Specifications Bottle x 60ml
Ingredient Desloratadine

Ingredient

Thành phần cho 5ml

Composition information	Content
Desloratadine	2.5mg

Uses

Indications

reduce symptoms in diseases: allergic rhinitis, itching, chronic urticaria.

Pharmacokology

Pharmacological group: Antihistamine H1.

ATC code: R06AX27.

Desloratadine is a three -round antihistamine receptor that has a long -lasting effect with H1 histamine resistance activity. The receptor base indicates that at a concentration of 2-3 ng/ml, the desloratadine has a significant interaction with H1 histamine receptor in humans. On in vitro, desloratadine inhibits the release of cell histamine in humans.

Dynamic pharmacokinetics

Research results distributed by radioactive isotopes on the mouse indicating that desloratadine does not pass through the brain blood barrier.Oral

by oral, desloratadine 5 mg/time/day, taken within 10 days, average time to achieve the peak plasma concentration is approximately 3 hours after drinking. Food and fruit juice do not affect the bioavailability of desloratadine.

Desloratadine converts into 3 - hydroxy desloratadine, an active and later metabolic metabolite into glucuronidase. Enzymes ensure the formation of 3 - hydroxy desloratadine has not been determined. Desloratadine and 3 - Hydroxy Desloratadine associated with plasma protein approximately 82% - 87% and 85% - 89%. The cohesion of desloratadine and 3 - Hydroxy Desloratadine does not change in patients with renal failure.

Desloratadine's semi -exhaust time is 27 hours. CMAX value (plasma peak concentration) and AUC (area under the curve) increased when using single dose from 5 - 20mg. Increased accumulation achieved after drinking 14 days suitable for the sale time and regular dose. Human research shows about 87% of the desloratadine dose found in urine and stool in the form of metabolites.

In human blending nodules with single dose and 5mg of desloratadine repetition indicates that antihistamine inhibitors effectively after 1 hour and 24 hours lasting.

Before taking Oral solution A.T Desloratadin 2.5mg An Thien reduces allergic rhinitis, itching, chronic urticaria (60ml)

How to use

Take oral use. Drink only once a day.

Dosage

Adults and children over 12 years: Take 10ml daily (measuring with attached cup). (Creatinine clearance What to do when overdose?

Overdose:

In adults, overdose often shows: drowsiness, tachycardia, headache. In children there are expressions of the tower, brushing the chest.

How to handle the drug overdose:

Desloratadine overdose treatment is usually symptomatic and supportive treatment. Causing vomiting with ipeca syrup, activated carbon. If vomiting is ineffective or contraindicated (patients with fainting, convulsions, lack of vomiting reflexes), the gastric lavage may be carried out with 0.9% sodium chloride solution and the intubation to prevent the inhalation of gastric juice.

Desloratadine is not eliminated by hemorrhage.

What to do when forgetting a dose?

Side Effects

Little side effects.

Desloratadine is well tolerated. Desloratadine causes some side effects such as headache, sleep, fatigue, dry mouth, shortness of breath, hangover, abdominal pain, discomfort, dizziness, hypersensitivity reaction. In children: The usual side effect is diarrhea, fever, insomnia, headache.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to desloratadine or other ingredients of the drug.

Be cautious when using

Caution with patients with liver failure.

Safe and effective when using desloratadine for children under 2 years of age has not been determined. When using desloratadine, there is a risk of dry mouth, especially in the elderly, and an increased risk of tooth decay. Therefore, clean oral hygiene when using desloratadine.

Authority warning:

The ingredients containing sucrose, sorbitol and sucralose, patients with rare genetic disorders such as fructose intolerance, glucose-galactose absorption disorders or enzyme deficiency Sucrose-Isomaltase should not use this drug.

Methyl paraben, Propyl Paraben is at risk of allergic reactions.

Each 5ml of drug solution contains 1g of sucrose, 1g sorbitol 70%, 2.5mg sucralose, consider when used for patients with diabetes. Each 5ml of drug solution contains 55mg of propylene glycol, consulting the doctor or pharmacist before giving children the drug, especially when the child is given other drugs containing propylene glycol or alcohol.

The effect of the drug on driving and operating machinery

In the treatment dose, the drug does not affect the ability to drive and operate machinery. However, note that headaches, fatigue, sleep, dizziness can occur during treatment.

Use drugs for women during pregnancy and lactation

There are no complete studies and good tests for the use of desloratadine during pregnancy. Desloratadine and metabolites Descarboethoxyloratadine are secreted into breast milk. Therefore only using desloratadine for pregnant and lactating women when necessary, with low doses and short time.

Drug interaction

drug interaction:

Concentrated with ketoconazole, erythromycin or cimetidine, increased desloratadine levels in plasma.

In tests: 48 hours should be stopped before conducting skin tests.

Drinking desloratadine with alcohol does not increase the risk of alcoholic behavior.

Cavalry:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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